• Pitt
  • Health Sciences
  • UPMC
Regenerative Medicine at the McGowan InstituteRegenerative Medicine at the McGowan InstituteRegenerative Medicine at the McGowan InstituteRegenerative Medicine at the McGowan Institute
  • Home
  • Our People
    • Faculty/Staff Bios (A-C)
    • Faculty/Staff Bios (D-I)
    • Faculty/Staff Bios (J-N)
    • Faculty/Staff Bios (O-S)
    • Faculty/Staff Bios (T-Z)
    • Core Faculty Publications
    • Administrative Resources
  • Our Innovations
    • Impact
    • Patent Matrix
    • Featured Innovations
      • Innovation Insights
      • Coulter Programs
      • Expert Exposés
      • Spinout Spotlight
    • Partnerships & Collaborations
      • Industry
      • Academia
      • Within Pitt
    • Contact
  • About Us
    • Welcome
    • Video
    • Statistics
    • Mission Statement
    • What Is Regenerative Medicine?
    • Contact Us
    • Clinical Site
  • Our Research
    • Focus Areas
      • Tissue Engineering and Biomaterials
      • Cellular Therapies
      • Medical Devices and Artificial Organs
      • Clinical Translation
    • Matrix
    • Centers
    • Laboratories
    • Clinical Trials
    • Initiatives
  • Media
    • Current News
    • News Archive
    • Video
    • Podcasts
    • Newsletter
    • Grant of the Month
    • Publication of the Month
    • Media Contact
    • Video Links
  • Professional Development
    • Seminar Series
    • Special Events
    • Student Interest Groups
    • CATER
    • Post-Doctoral Opportunities
    • Career Opportunities
    • Wiegand Summer Internship
    • Admissions
    • Summer School
    • 2019 Scientific Retreat
    • Human Performance Optimization Symposium

EVLP: Expand the Donor Pool and Lead to Better Transplant Outcomes

    Current News EVLP: Expand the Donor Pool and Lead to Better Transplant Outcomes

    EVLP: Expand the Donor Pool and Lead to Better Transplant Outcomes

    By: The McGowan Institute For Regenerative Medicine | Category: Current News, Epidemiology | May 9, 2018

    DCunha

    Ex vivo lung perfusion (EVLP) has developed as a novel organ preservation method in lung transplantation. EVLP allows physicians to evaluate lung graft function and condition prior to transplantation, leading to the possibility to utilize marginal lung grafts and/or high-risk donor lungs including donation after circulatory death (DCD), atelectasis lung, lung with slight edema and functional problem without other concerns, as well as the lung grafts met to normal criteria. Also, EVLP allows reconditioning of such lung grafts on ex vivo prior to transplantation using various options for treatment including high dose drug administration, stem cell transplantation, gene transfection, ex vivo surgery, and so on.

    “Transplants are a very exciting field right now, very exciting time and there’s a lot going on,” McGowan Institute for Regenerative Medicine affiliated faculty member Jonathan D’Cunha, MD, PhD, Associate Professor of Cardiothoracic Surgery and Chief of the Lung Transplant Division at the University of Pittsburgh Medical Center, told Andrew Tarantola of Engadget. “It doesn’t matter whether it’s general urinary transplant or lungs or heart or liver, kidney, they all have different aspects or components to them which we’re trying to push the field further and further.”

    “Many patients who are waiting for lungs can’t get a lung transplant because the donor supply is so limited,” he said. “So, we’re always looking to improve things and expand the donor pool and new technologies are under development by many investigators to try to achieve this goal.”

    Recently, a modified EVLP system, “Dual EVLP,” where pulmonary artery and bronchial artery are synchronously perfused has been developed and achieved more physiological and therapeutic environment which may be considered to lead better graft recovery. These therapeutic means on EVLP have much possibility to expand the donor pool and lead better transplant outcomes. Therefore, it is important as a translational research to see the beneficial and/or adverse effects of EVLP and the ex vivo pretreatment to high risk donor lungs for further development of lung transplantation. The aims of this study are to test EVLP and Dual EVLP for high risk donor lung and to clarify their effects on the grafts during preservation and after transplantation.

    “Having the time to assess [donor organs] properly and make good judgments so you have a good patient outcome is absolutely critical,” Dr. D’Cunha said. “Additionally, what the future may hold with things like Ex Vivo Lung Perfusion is the opportunity to even repair or intervene on lungs to make them better.”

    Read more…

    Engadget

    University of Pittsburgh Department of Cardiothoracic Surgery:  Ex vivo lung perfusion prior to lung transplantation for high risk donor lungs

    Print Friendly
    No tags.

    • site map
    • links
    • contact
    • subscribe to our newsletter
    © Copyright 2019 McGowan Institute for Regenerative Medicine
    A program of the University of Pittsburgh and the University of Pittsburgh Medical Center
    • Home
    • Our People
      • Faculty/Staff Bios (A-C)
      • Faculty/Staff Bios (D-I)
      • Faculty/Staff Bios (J-N)
      • Faculty/Staff Bios (O-S)
      • Faculty/Staff Bios (T-Z)
      • Core Faculty Publications
      • Administrative Resources
    • Our Innovations
      • Impact
      • Patent Matrix
      • Featured Innovations
        • Innovation Insights
        • Coulter Programs
        • Expert Exposés
        • Spinout Spotlight
      • Partnerships & Collaborations
        • Industry
        • Academia
        • Within Pitt
      • Contact
    • About Us
      • Welcome
      • Video
      • Statistics
      • Mission Statement
      • What Is Regenerative Medicine?
      • Contact Us
      • Clinical Site
    • Our Research
      • Focus Areas
        • Tissue Engineering and Biomaterials
        • Cellular Therapies
        • Medical Devices and Artificial Organs
        • Clinical Translation
      • Matrix
      • Centers
      • Laboratories
      • Clinical Trials
      • Initiatives
    • Media
      • Current News
      • News Archive
      • Video
      • Podcasts
      • Newsletter
      • Grant of the Month
      • Publication of the Month
      • Media Contact
      • Video Links
    • Professional Development
      • Seminar Series
      • Special Events
      • Student Interest Groups
      • CATER
      • Post-Doctoral Opportunities
      • Career Opportunities
      • Wiegand Summer Internship
      • Admissions
      • Summer School
      • 2019 Scientific Retreat
      • Human Performance Optimization Symposium
    Regenerative Medicine at the McGowan Institute