Selected recent publications:

• Soto-Gutierrez A., Zhang L., Medberry C., Fukumitsu K., Faulk D., Jiang H., Reing J., Gramignoli R., Komori J., Ross M., Nagaya M., Lagasse E., Stolz D., Strom S.C., Fox I.J., and Badylak S. A Whole Organ Regenerative Medicine Approach for Liver Replacement. Tissue Engineering Part C. (2011). In press.
• Hoppo, T., Komori, J. Manohar R., Stolz D.B. and Lagasse E. Rescue of Lethal Hepatic failure by hepatized lymph nodes in mice. Gastroenterology. (2011). 140 (2) 656-666.
• Teisanu, R.M., Lagasse E., Whitesides J. and Stripp B. R. Prospective Isolation of Bronchiolar Stem Cells. Stem Cells. (2009). 27(3):612-22.
• Odoux C., Fohrer F., Hoppo T., Guzik T., Cavelli A., Stolz D.B., Lewis D.W., Gollin S.M., Gamblin T.C., Geller D.A., and Lagasse E. A Stochastic Model for Cancer Stem Cell Origin in Metastatic Colon Cancer. Cancer Res. (2008). 68(17): 6932-6941.
• Xiong A., Austin W.T., Lagasse E., Uchida N., Tamaki S., Bordier B., Weissman I.L. Glenn JS and Millan M. Isolation of Human Fetal Liver Progenitors and their Enhanced Proliferation by 3-Dimensional Co-culture with Endothelial Cells. Tissue Eng. (2008). Part A. Apr 23.
• Omidvar N., Kogan S., Beurlet S., le Pogam C., Janin A., West R., Noguera ME, Reboul M., Soulie A., Leboeuf C., Setterblad N., Felsher D., Lagasse E., Mohamedali A., Shaun N., Thomas B., Fenaux P., Fontenay M., Pla M., Mufti G., Irving Weissman I.L., Chomienne C. and Padua R.A. BCL-2 and Mutant NRAS Interact Physically and Functionally in a Mouse Model of Progressive Myelodysplasia. Cancer Research. (2007). 67:11657-11667.
• Iwata A, Stevenson VM, Minard A, Tasch M, Tupper J, Lagasse E, Weissman I, Harlan JM, and Winn RK. Over-Expression of Bcl-2 Provides Protection in Septic Mice by a trans Effect. J. Immunol. (2003). 15;171(6):3136-41.
• Wang X., Foster M., Al-Dhalimy M., Lagasse E., Finegold M.and Grompe M. The origin and liver repopulating capacity of murine oval cells. Proc. Natl. Acad. Sci. USA. (2003). 100 (Suppl 1): 11881-8.
• Wang X., Willenbring H., Akkari Y., Torimaru Y., Foster M., Al-Dhalimy M., Lagasse E., Finegold M., Olson S. and Grompe M. Cell fusion is the principal source of bone marrow derived hepatocytes. Nature. (2003). 422:897-901.
• Jaiswal S., Traver D., Miyamoto T., Akashi K., Lagasse E., and Weissman I.L. Development of murine chronic and acute myelogenous leukemia with targeted expression of BCR/ABL to common myeloid progenitors. Proc. Natl. Acad. Sci. USA. (2003). 100(17):10002-7.
• Wang X., Al-Dhalimy M., Lagasse E., Finegold M., and Grompe M. Kinetics of liver repopulation after bone marrow transplantation. Am. J. Path. (2002). 161:565-74.
• Yuan Y., Zhou L., Miyamoto T., Iwasaki H., Harakawa N., Hetherington C.J., Burel S.A., Lagasse E., Weissman I.L., Akashi K., and Zhang Dong-Er. AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations. Proc. Natl. Acad. Sci. USA. (2001). 98: 10398-10403.
• Wang X., Al-Dhalimy, M., Lagasse, E., Finegold M. and Grompe, M. Liver repopulation and Correction of Metabolic Liver Disease by Transplanted Adult Mouse Pancreatic Cells. Am. J. Path. (2001). 158:571-579.
• Kogan S.C., Brown D.E., Schultz D.B., Truong BT.H., Lallemand-Breitenbach V., Guillemin M.C., Lagasse E., Weissman I.L. and Bishop J.M. BCL-2 Cooperates with Promyelocytic Leukemia Retinoic Acid Receptor  Chimeric Protein (PMLRAR) to Block Neutrophil Differentiation and Initiate Acute Leukemia. J. Exp. Med. (2001). 193: 531-544.
• Lagasse E., Connors H., Al-Dhalimy M., Reitsma M., Dohse M., Osborne L., Wang X., Finegold M., Weissman I.L., and Grompe M. Purified hematopoietic stem cells can differentiate to hepatocyte in vivo. Nature Medicine. (2000). 11:1229-1234.

CONTACT INFORMATION

Dr. Eric Lagasse, Pharm.D., Ph.D.
Phone: (412) 624-5285
Email: lagasse@pitt.edu