Selected recent publications:

• Qu, H., Tu, Y., Shi, X., Larjava, H., Saleem, M. A., Shattil, S. J., Fukuda, K., Qin, J., Kretzler, M., and Wu, C. Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins. J. Cell Sci. (2011) 124:879-91


• Wang, D., Li, Y., Wu, C. and Liu, Y. PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expression, PLoS ONE (2011) 6(2):e17048


• Donthamsetty, S., Bhave, V. S., Kliment, C. S., Bowen, W. C., Mars, W. M., Bell, A. W., Stewart, R. E., Orr, A., Wu, C., and Michalopoulos, G. M. Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene. Hepatology (2011) 53(2):587-95


• Bledzka, K., Bialkowska, K., Nie, H., Qin, J., Byzova, T., Wu, C., Plow, E. F. and Ma, Y.-Q. Tyrosine phosphorylation of ?3 integrin regulates kindlin-2 binding and integrin activation. J. Biol. Chem. (2010) 285(40):30370-4. PMCID: PMC2945529


• Perera, P. M. , Wypasek, E., Madhavan, S., Rath-Deschner, B., Liu, J., Nam, J., Rath, B., Huang, Y., Deschner, J., Piesco, N., Wu, C., Agarwal, S. Mechanical signals control Sox-9, Vegf and c-Myc expression and cell proliferation during inflammation via Integrin-linked kinase, B-Raf, and ERK 1/2-dependent signaling in articular chondrocytes. Arthritis Research & Therapy (2010) 12(3):R106. PMCID: PMC2911896


• Han, Y.-C., Yu, Y. P., Nelson, J., Wu, C., Michalopoulos, G. K. and Luo, J.-H. Interaction of integrin linked kinase (ILK) and MCM7 mediating integrin ?7 induced cell growth suppression. Cancer Research (2010) 70(11):4375-84.


• Kang, Y. S., Li, Y., Dai, D., Kiss, L.P., Wu, C. and Liu, Y. Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria. Kidney International (2010) 78(4):363-73.


• Yuan, Y., Dong, H. P., Nymoen, D. A., Nesland, J. M., Wu, C., and Davidson, B. PINCH-2 expression in cancers involving the serosal cavities. Cytopathology (2010) May 25. [Epub ahead of print] PMID: 20500520


• Owen, G. R., Häkkinen, L., Wu, C., and Larjava, H. A reproducible technique for specific labeling of antigens using preformed fluorescent molecular IgG-F(ab')2 complexes from primary antibodies of the same species. Microsc. Res. Tech. (2010) 73(6):623-30


• Donthamsetty, S., Bowen, W., Mars, W., Bhave, B., Luo, J. H., Wu, C., Hurd, J., Orr, A., Bell, A., and Michalopoulos G. M., Liver Specific Ablation of Integrin Linked Kinase (ILK) in Mice Results in Enhanced and Prolonged Cell Proliferation and Hepatomegaly after Phenobarbital Administration. Toxicol. Sci. (2010) 113(2):358-66. PMCID: PMC2807039


• Fukuda, K., Gupta, S. Chen, K., Wu, C. and Qin, J. The pseudo-active site of ILK is essential for its binding to ?-parvin and localization to focal adhesions. Mol. Cell (2009) 36(5):819-830. PMCID: PMC2796127


• Shao, H., Wu, C., and Wells, A. Phosphorylation of ?-actinin-4 upon epidermal growth factor (EGF) exposure regulates its interaction with actin. J. Biol. Chem. (2009) 285(4):2591-600. PMCID: PMC2807316


• Zhao, J., Zhang, Y., Ithychanda, S. S., Tu, Y., Chen, K., Qin, J. and Wu, C. Migfilin interacts with Src and contributes to cell-matrix adhesion- mediated survival signaling. J. Biol. Chem. (2009) 284(49):34308-20. PMCID: PMC2797199


• Yuan, Y., Nymoen, D. A., Dong, H. P., Stavnes, H. T., Rossnes, A. K., Bjørang, O., Wu, C., Nesland, J. M., Davidson, B., Tenascin-X is a novel diagnostic marker of malignant mesothelioma. Am. J. Surg. Pathol. (2009) 33(11):1673-82


• Liang, X. Sun, Y.F., Yi, M. Q., Powell, H., Rearden, A., Wu, C., Evans, S. E. and Chen, J. Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality. Circulation (2009) 120(7):568-576


• Apte, U., Gkretsi, V., Bowen, W. C., Mars, W. M., Luo, J. H., Donthamsetty, S., Orr, A., Monga, S. P., Wu, C. and Michalopoulos, G. K. Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase. Hepatology (2009) 50(3):844-851

CONTACT INFORMATION

Dr. Cary Wu
Phone: (412) 648-2350
Email: carywu@pitt.edu