David Whitcomb, M.D., Ph.D.
Selected recent publications:

  • Schneider A, Barmada MM, Slivka A, Martin JA, Whitcomb DC. Analysis of tumor necrosis factor-alpha, transforming growth factor-beta1, interleukin-10, and interferon-gamma polymorphisms in patients with alcoholic chronic pancreatitis. Alcohol 32: 19-24, 2004.
  • Schneider A, Tögel S, Barmada MM, Whitcomb DC. Genetic analysis of the glutathione s- transferase genes MGST1, GSTM3, GSTT1 and GSTM1 in patients with hereditary pancreatitis. J Gastroenterol 39: 783-7, 2004
  • Schneider A, Barmada MM, Slivka A, Martin JA, Whitcomb DC. Clinical characteristics of patients with idiopathic chronic pancreatitis and SPINK1 mutations. Scand J Gastroenterol 2004 Sep; 39 (9):903-4.
  • Gaisano HY, Sheu L, Whitcomb DC. Alcohol chronic pancreatitis involves displacement of Munc18c from the pancreatic acinar basal surface. Pancreas. 28. 395-400, 2004.
  • Whitcomb DC, Ermentrout GB. A mathematical model of the pancreatic duct cell generating high bicarbonate concentrations in pancreatic juice. Pancreas. 29, E30-E40, 2004
  • Deng X, Wood PG, Eagon PK, Whitcomb DC. Chronic alcohol-induced alterations in the pancreatic secretory control mechanisms. Dig Dis Sci 49. 805-19,2004.
  • Khalid A, Pal R, Sasatomi E, Swalsky P, Slivka A, Whitcomb DC, Finkelstein S. Use of microsatellite marker LOH in accurate diagnosis of pancreatobiliary malignancy from brush cytology samples. Gut (In Press).
  • Howes N, Lerch MM, Greenhalf W, Stocken DD, Ellis I, Simon P, Truninger K, Ammann R, Cavallini G, Charnley RM, Uomo G, Delhaye M, Spicak J, Drumm B, Jansen J, Mountford R, Whitcomb DC, Neoptolemos JP. Clinical and Genetic Characteristics of Hereditary Pancreatitis in Europe. J Clin Gastro 2004; 2:252-261.
  • Deng X, Wood PG, Eagon PK, Whitcomb DC. Rapid Adaptation of Pancreatic Exocrine Function to Short Term Alcohol Feeding in Rats. Pancreatology 2005;5:183-195.
  • Schneider A, Barmada MM, Whitcomb DC. Keratin 8 mutations are not associated with hereditary, sporadic and alcoholic chronic pancreatitis in the United States. Pancreatology (accepted with revisions)
  • Deng X, Wang L, Elm MS, Gabbaizedeh D. Diorio GJ, Eagon PE, Whitcomb DC Chronic alcohol consumption accelerates fibrosis in response to cerulein-induced pancreatitis in the rat. Am J Pathol. 2005 Jan;166(1):93-106.
  • Tschop M, Castaneda TR, Joost HG, Thone-Reineke C, Ortmann S, Klaus S, et al. Physiology: does gut hormone PYY3-36 decrease food intake in rodents? Nature 2004;430(6996)
  • Rossi L, Parvin S, Hassan Z, Hildebrand P, Keller U, Ali L, et al. Diabetes mellitus in Tropical Chronic Pancreatitis Is Not Just a Secondary Type of Diabetes. Pancreatology 2004;4(5):461-467
  • Oruc N, Whitcomb DC. The Functional Angiotensin Converting Enzyme Gene I/D Polymorphism Does not Alter Susceptibility to Chronic Pancreatitis. JOP. 2004 Nov 10;5(6):457-63.
  • Pogue-Geile K, J Mackey, Ryan George, P Wood, K Lee, A Moser, J Lyons-Weiler, DC Whitcomb. A New Microarray, Enriched in Pancreas and Pancreatic Cancer cDNAs to Identify Genes Relevant to Pancreatic Cancer. Cancer Genomics and Proteomics (in press)
  • Schneider A, Lawrence ED, Barmada MM, Norris JM, Hamman RF, Marshall JA, Ferrell RE, Whitcomb DC. The SPINK1 N34S mutation is not associated with type 2 diabetes mellitus in a population of the United States. (in press)
  • Whitcomb DC, Sepulveda AR. Molecular and genetic aspects of gastrointestinal and pancreatic disease. Clin Lab Med. 2005 Mar;25(1):17-37.
  • Transforming growth factor-beta1, interleukin-10 and interferon-gamma cytokine polymorphisms in patients with hereditary, familial and sporadic chronic pancreatitis. Pancreatology. 2004;4(6):490-4.
  • Rossi L, Parvin S, Hassan Z, Hildebrand P, Keller U, Ali L, Beglinger C, Azad Khan AK, Whitcomb DC, Gyr N. Diabetes mellitus in Tropical Chronic Pancreatitis is not just a secondary type of diabetes. Pancreatology. 2004;4(5):461-7 Pancreatic Diseases: Novel Mechanisms and Management. Ed. DC Whitcomb, R Brand, M Lerch. Gastroenterology Clinics of North America, Volume 33, Number 4 (Dec, 2004). WB Saunders Company, Philadelphia, PA.
  • Molecular and Genetic Aspects of Gastrointestinal Disease, Guest Ed DC Whitcomb and A Sepulveda. Clinics in Laboratory Medicine. Volume 25, Number 1. (Spring 2005) WB Saunders Company, Philadelphia, PA (in press)
  • Sharif S, Plevy S, Finn OJ, Whitcomb DC. “Hereditary Pancreatitis and its Link to Pancreatic Cancer”, Chapter 8, In: Pancreatic Cancer, ed DD Van Hoff, DB Evans and RH Hruban, Jones and Bartlett Publishers, Sadbury, MA. In Press.
  • Whitcomb DC, Lowe ME. Pancreatitis: Acute and Chronic. In: Walker WA, Goulet O, Kleinman RE, Sherman PM, Shneider BL, Sanderson IR, editors. Pediatric Gastrointestinal Disease: Pathophysiology, Diagnosis, Management. Hamilton (ON): BC: Decker; 2004. p. 1584-1597.
  • Papachristou GI, Whitcomb DC. Etiopathogenesis of chronic pancreatititis: a genetic disease with some precipitating factors? In: Dόminguez-Muňoz JE. Clinical Pancraetology for Practising Gastroenterologists and Surgeons. Malden, MA: Blackwell Publishing, 2005. p. 192-200.

CONTACT INFORMATION

Dr. David Whitcomb
Phone: (412) 648-9604
Email: whitcomb@pitt.edu