Selected recent publications:

• YH Bae, Z Ding, T Das, A Wells, F Gertler, P Roy (2011). Profilin-1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing MDA-MB-231 cell motility. Proceedings of the National Academy of Sciences (USA), in press.
• H Shao, J-C Wang, MR Pollak, A Wells (2010). a–Actinin-4 is essential for maintaining the spreading, motility, and contractility of fibroblasts. PLoS One 5, e13291.
• K Silver, L Leloup, KG Freeman, A Wells, JD Lillich (2010). Non-steroidal anti-inflammatory drugs inhibit calpain activity and membrane localization of calpain 2 protease. International Journal of Biochemistry and Cell Biology 42. 2030-2036. PMID: 20854926.
• L Leloup, H Shao, Y-H Bae, B Deasy, D Stolz, P Roy, A Wells (2010). M-Calpain activation is regulated by its membrane localization and by its binding to PIP2. Journal of Biological Chemistry 285, 33549-33566. PMID: 20729206. PMC2963356.
• YL Chao, CR Shepard, A Wells (2010). Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition. Molecular Cancer 9, 179. PMID: 20609236. PMC2907333.
• P Krishna, M Regner, J Palko, S Abramowitch, J Jiang, A Wells (2010). The effects of decorin and HGF-primed vocal fold fibroblasts in vitro and ex vivo in a porcine model of vocal fold scarring. The Laryngoscope, in press.
• BL Hood, J Grahovac, MS Flint, M Sun, N Charro, D Becker, A Wells, TP Conrads (2010). Proteomic analysis of laser microdissected melanoma cells from skin organ cultures. Journal of Proteome Research 9, 3656-3663. PMID: 20459140. PMCID: NIHMS209402
• M Li, JM Aliotta, JM Asara, Q Wu, LD Tucker, A Wells, PJ Queensberry, B Ramratnam (2010). Intercellular transfer of proteins as identified by stable isotope labeling of amino acids in cell culture. Journal of Biological Chemistry 285, 6285-6297. PMID: 20026604. PMCID: PMC2825424.
• H Shao, C Wu, A Wells (2010). Phosphorylation of a-actinin-4 upon epidermal growth factor (EGF) exposure regulates its interaction with actin. Journal of Biological Chemistry 285, 2591-2600. PMID: 19920151. PMC2807316.
• Shao H, Yi XM, Wells A.  Epidermal growth factor protects fibroblasts from apoptosis via PI3 kinase and Rac signaling pathways.  Wound Repair and Regeneration.  2008 Jul-Aug;16(4):551-8.
• R Simpson, A Wells, DW Thomas, P Stephens, R Steadman, AO Phillips (2010). Aging fibroblasts resist phenotypic maturation due to impaired hyaluronan-dependent CD44/EGF receptor signaling. American Journal of Pathology, in press. PMID: 20093489. PMC2832144.
• CC Yates, P Krishna, D Whaley, R Bodnar, T Turner, A Wells (2010). Lack of CXC chemokine receptor 3 (CXCR3) signaling leads to hypertrophic and hypercellular scarring. American Journal of Pathology 176, 1743-1755. PMID: 20203286. PMCID: PMC2843466
• MO Platt, CL Wilder, A Wells, LG Griffith,  DA Lauffenburger (2009). Multi-pathway kinase signatures of multipotential stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells. Stem Cells 27, 2804-2814. PMID: 19750537.
• Z Ding, D Gau, B Deasy, A Wells, P Roy (2009). Both actin and polyproline interactions of profilin-1 are required for migration, invasion and capillary morphogenesis of vascular endothelial cells. Experimental Cell Research 315, 2963-2973. PMID: 19607826. PMC2757537
• NA Mercantonio, C A Boehm, R Rozic, A Au, A Wells, G Muschler, LG Griffith (2009). Tethered epidermal growth factor increases connective tissue progenitor colony formation. Biomaterials 30, 4629-4638. PMID: 19540579.
• MO Platt, AJ Roman, A Wells,  DA Lauffenburger, LG Griffith (2009). Sustained epidermal growth factor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells.  Journal of Cellular Physiology 221, 306-317. PMID: 19544388.

CONTACT INFORMATION

Dr. Alan Wells
Phone: (412) 647-7813
Email: wellsa@upmc.edu