Alan Wells, M.D.
Selected recent publications:

  • AK Larsen, T DeVeyra, Z Jia, A Wells, P Dutt, JS Elce (2004). Expression of human, mouse, and rat m-calpains in Escherichia coli and in murine fibroblasts. Protein Expression and Purification 33, 246-255.
  • A Glading, R Bodnar, IJ Reynolds, H Shiraha, L Satish, DA Potter, HC Blair, A Wells (2004). EGF activates m-calpain (calpain 2), at least in part, by ERK-mediated phosphorylation. Molecular and Cellular Biology 24, 2499-2512.
  • P Kornblith, RL Ochs, A Wells, MJ Gabrin, J Piwowar, A Chattopadhyay, LK George, D Burholt (2004). Differential in vitro effects of chemotherapeutic agents on primary cultures of human ovarian carcinoma. International Journal of Gynecologic Oncology 14, 607-615.
  • L Satish, M Babu, KT Tran, P Hebda, A Wells (2004). Keloid fibroblast responsiveness to epidermal growth factor and activation of downstream intracellular signaling pathways. Wound Repair and Regeneration 12, 183-192.
  • L Jing, L Liu, YP Yu, R Dhir, M Acquafondada, D Landsittel, K Cieply, A Wells, JH Luo (2004). Expression of myopodin induces suppression of tumor growth and metastasis. American Journal of Pathology 164, 1799-1806.
  • A Iwabu, K Smith, FD Allen, DA Lauffenburger, A Wells (2004). EGF induces fibroblast contractility and motility via a PKC-dependent pathway. Journal of Biological Chemistry 279, 14551-14560.
  • Y Yagi, I Ahmed, W Gross, MJ Becich, AJ Demetrix, A Wells, CA Wiley, GK Michalopoulos, SA Yousem, B Barnes, JR Gilbertson (2004). Webcasting pathology department conferences in a geographically distributed medical center. Human Pathology 35, 790-797.
  • A Mamoune, J Kassis, S Kharait, S Kloecker, E Manos, DA Jones, A Wells (2004). DU145 human prostate carcinoma invasiveness is modulated by urokinase receptor (uPAR) downstream of epidermal growth factor receptor (EGFR) signaling. Experimental Cell Research 299, 91-100.
  • KS Priya, G Arumugam, B Rathinam, A Wells, M Babu (2004). Celosia argentea Linn. Leaf extract improves wound healing in a rat burn wound model. Wound Repair and Regeneration 12, 618-625.
  • B Hendriks, G Orr, A Wells, HS Wiley, DA Lauffenburger (2005). Parsing ERK activation reveals quantitatively equivalent contributions from EGFR and HER2 in human mammary epithelial cells. Journal of Biological Chemistry 280, 6157-6169.
  • C Yates, A Wells, T Turner (2005). Luteinizing hormone releasing hormone (LHRH) antalog reverses the cell adhesion profile of EGFR overexpressing DU-145 human prostate carcinoma subline. British Journal of Cancer 92, 366-375.
  • L Satish, HC Blair, A Glading, A Wells (2005). IP-9 (CXCL11) induced cell motility in keratinocytes requires calcium flux-dependent activation of -calpain. Molecular and Cellular Biology 25, 1922-1941. 93. S Hauteniemi, S Kharait, A Iwabu, A Wells, DA Lauffenburger (2005). Modeling and prediction of signal transduction cascades using decision trees. Bioinformatics 21, 2027-2035.
  • H Gallion, WA Christopherson, RL Coleman, L DeMars, T Herzog, S Hosford, M Schellhas, A Wells, B-U Sevin (2005). Progression-free interval in ovarian cancer and predictive value of an ex vivo chemosensitivity assay. International Journal of Gynecology, in press.
  • SY Lai, EE Childs, S Xi, FM Coppelli, WE Gooding, A Wells, RL Ferris, JR Grandis (2005). Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma. Oncogene 24, 4442-4449.
  • J Wang, X Zhang, SM Thomas, JR Grandis, A Wells, ZG Chen, RL Ferris (2005). Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasion and prosurvival pathways in head and neck cancer cells independent of EGFR. Oncogene, in press.
  • K Tamama, VH Fan, LG Griffith, HC Blair, A Wells (2005). Epidermal growth factor as candidate for ex vivo expansion of bone marraw-derived mesenchymal stem cells. Stem Cells, in press.

CONTACT INFORMATION

Dr. Alan Wells
Phone: (412) 647-7813
Email: wellsa@upmc.edu