Simon C. Watkins, Ph.D.
Selected recent publications:

  • Salter RD, Tuma-Warrino RJ, Hu PQ, Watkins SC. Rapid and extensive membrane reorganization by dendritic cells following exposure to bacteria revealed by high-resolution imaging. J Leukoc Biol. 2004 Feb;75(2):240-3.(COVER)
  • Wang Z, Cook T, Alber S, Liu K, Kovesdi I, Watkins SC, Vodovotz Y, Billiar TR, Blumberg D. Adenoviral gene transfer of the human inducible nitric oxide synthase gene enhances the radiation response of human colorectal cancer associated with alterations in tumor vascularity. Cancer Res. 2004 Feb 15;64(4):1386-95.
  • Jones HM, Hamilton KL, Papworth GD, Syme CA, Watkins SC, Bradbury NA, Devor DC. Role of the NH2-terminus in the assembly and trafficking of the intermediate conductance Ca2+-activated K+ channel, hIK1.J Biol Chem. 2004 Jan 30
  • Hong KU, Reynolds SD, Watkins S, Fuchs E, Stripp BR. Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium. Am J Pathol. 2004 Feb;164(2):577-88.
  • Larregina AT, Morelli AE, Tkacheva O, Erdos G, Donahue C, Watkins SC,Thomson AW, Falo LD Jr. Highly efficient expression of transgenic proteins by naked DNA-transfected dendritic cells through terminal differentiation.Blood. 2004 Feb 1;103(3):811-9
  • Hu PQ, Tuma-Warrino RJ, Bryan MA, Mitchell KG, Higgins DE, Watkins SC ,Salter RD. Escherichia coli expressing recombinant antigen and listeriolysin O stimulate class I-restricted CD8+ T cells following uptake by human APC.J Immunol. 2004 Feb 1;172(3):1595-601
  • Keyel PA, Watkins SC, Traub LM. Endocytic adaptor molecules reveal an endosomal population of clathrin by total internal reflection fluorescence microscopy.J Biol Chem. 2004 Jan 12
  • Moalli PA, Talarico LC, Sung VW, Klingensmith WL, Shand SH, Meyn LA, Watkins SC. Impact of menopause on collagen subtypes in the arcus tendineous fasciae pelvis.Am J Obstet Gynecol. 2004 Mar;190(3):620-7.
  • Baker LC, Wolk R, Choi BR, Watkins S, Plan P, Shah A, Salama G. Effects of Mechanical uncouplers, Diacetyl Monoxime and Cytochalasin-D on the Electrophysiology of Perfused Mouse Hearts. Am J Physiol Heart Circ Physiol. 2004 Jun 10
  • Hoffelder DR, Luo L, Burke NA, Watkins SC, Gollin SM, Saunders WS. Resolution of anaphase bridges in cancer cells. Chromosoma. 2004 Jun;112(8):389-97.
  • Ho M, Post CM, Donahue LR, Lidov HG, Bronson RT, Goolsby H, Watkins SC, Cox GA, Brown RH Jr. Disruption of muscle membrane and phenotype divergence in two novel mouse models of dysferlin-deficiency. Hum Mol Genet. 2004 Jul 14
  • Yang R, Uchiyama T, Alber SM, Han X, Watkins SK, Delude RL, Fink MP. Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis. Crit Care Med. 2004 Jul;32(7):1453-9.
  • Du L, Bayir H, Lai Y, Zhang X, Kochanek PM, Watkins SC, Graham SH, Clark RS. Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway. J Biol Chem. 2004 Jul 1
  • Baker LC, Wolk R, Choi BR, Watkins S, Plan P, Shah A, Salama G. Effects of Mechanical uncouplers, Diacetyl Monoxime and Cytochalasin-D on the Electrophysiology of Perfused Mouse Hearts. Am J Physiol Heart Circ Physiol. 2004 Jun 10
  • Tsugawa T, Kuwashima N, Sato H, Fellows-Mayle WK, Dusak JE, Okada K, Papworth GD, Watkins SC, Gambotto A, Yoshida J, Pollack IF, Okada H. Sequential delivery of interferon-alpha gene and DCs to intracranial gliomas promotes an effective antitumor response.Gene Ther. 2004 Sep 2
  • Mizuno Y, Guyon JR, Watkins SC, Mizushima K, Sasaoka T, Imamura M, Kunkel LM, Okamoto K Beta-synemin localizes to regions of high stress in human skeletal myofibers. Muscle Nerve. 2004 Sep;30(3):337-46.
  • Ramani R, Mathier M, Wang P, Gibson G, Togel S, Dawson J, Bauer A, Alber S, Watkins SC, McTiernan CF, Feldman AM. Inhibition of tumor necrosis factor receptor-1-mediated pathways has beneficial effects in a murine model of postischemic remodeling.Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1369-77
  • Okada H, Tsugawa T, Sato H, Kuwashima N, Gambotto A, Okada K, Dusak JE, Fellows-Mayle WK, Papworth GD, Watkins SC, Chambers WH, Potter DM, Storkus WJ, Pollack IF. Delivery of interferon-alpha transfected dendritic cells into central nervous system tumors enhances the antitumor efficacy of peripheral peptide-based vaccines.Cancer Res. 2004 Aug 15;64(16):5830-8.
  • St Croix CM, Stitt MS, Leelavanichkul K, Wasserloos KJ, Pitt BR, Watkins SC. Nitric oxide-induced modification of protein thiolate clusters as determined by spectral fluorescence resonance energy transfer in live endothelial cells. Free Radic Biol Med. 2004 Sep 15;37(6):785-92.
  • Cetin S, Dunklebarger J, Li J, Boyle P, Ergun O, Qureshi F, Ford H, Upperman J, Watkins S, Hackam DJ. Endotoxin differentially modulates the basolateral and apical sodium/proton exchangers (NHE) in enterocytes. Surgery. 2004 Aug;136(2):375-83.
  • Tan RJ, Fattman CL, Watkins SC, Oury TD. Redistribution of pulmonary EC-SOD after exposure to asbestos.J Appl Physiol. 2004 Aug 6
  • Morelli AE, Larregina AT, Shufesky WJ, Sullivan ML, Stolz DB, Papworth GD, Zahorchak AF, Logar AJ, Wang Z, Watkins SC, Falo Jr LD, Thomson AW. Endocytosis, Intracellular Sorting and Processing of Exosomes by Dendritic Cells. Blood. 2004 Jul 29
  • Ho M, Post CM, Donahue LR, Lidov HG, Bronson RT, Goolsby H, Watkins SC, Cox GA, Brown RH Jr. Disruption of muscle membrane and phenotype divergence in two novel mouse models of dysferlin deficiency. Hum Mol Genet. 2004 Sep 15;13(18):1999-2010
  • Thotala D, Schafer EA, Majumder B, Janket ML, Wagner M, Srinivasan A,Watkins S, Ayyavoo V. Structure-functional analysis of human immunodeficiency virus type 1 (HIV-1)Vpr: role of leucine residues on Vpr-mediated transactivation and virus replication.Virology. 2004 Oct 15;328(1):89-100.
  • Yang r, uchiyama t, watkins sk, han x, fink mp. Ethyl pyruvate reduces liver injury in a murine model of extrahepatic cholestasis.shock. 2004 oct;22(4):369-375.
  • Zhu Y, Stolz DB, Guo F, Ross MA, Watkins SC, Tan BJ, Qi RZ, Manser E, Li QT,Bay BH, Teo TS, Duan W. Signaling via a novel integral plasma membrane pool of a serine/threonine protein kinase PRK1 in mammalian cells.FASEB J. 2004 Sep 16

CONTACT INFORMATION

Dr. Simon Watkins
Phone: (412) 648-3051
Email: swatkins@pitt.edu