William R. Wagner, Ph.D.

Selected recent publications:

  • Guan J, Sacks MS, Beckman EJ, Wagner WR: Biodegradable poly(ether ester urethane)urea elastomers based on poly(ether ester) triblock copolymers and putrescine: synthesis, characterization and cytocompatibility. Biomaterials 25:85-96 (2004).

  • Stankus JJ, Guan J, Wagner WR: Fabrication of biodegradable, elastomeric scaffolds with sub-micron morphologies. J Biomed Mater Res 70A:603-14 (2004).

  • Wagner WR, Borovetz HS, Griffith BP: Implantable cardiac assist devices. Biomaterials Science: An Introduction to Materials in Medicine, 2nd Edition, Academic Press, San Diego, CA, (2004).

  • Villanueva FS, Wagner WR, Vannan MA, Narula J. Targeted ultrasound imaging using microbubbles. Cardiol Clin. 22:283-98 (2004).

  • Stankus JJ, Guan J, Wagner WR. Elastomers, biodegradable. Encyclopedia of Biomaterials and Biomedical Engineering. G.E. Wnek and G.L. Bowlin, Eds., Marcel Dekker, N.Y., (2004).

  • Guan J, Fujimoto KL, Sacks MS, Wagner WR: Preparation and characterization of highly porous, biodegradable polyurethane scaffolds for soft tissue applications. Biomaterials 26:3961-71 (2005).

  • Weller GER, Wong MKK, Modzelewski RA, Lu E, Klibanov AL, Wagner WR, Villanueva FS: Ultrasonic imaging of tumor angiogenesis using contrast microbubbles targeted via the tumor-binding peptide arginine-arginine-leucine. Cancer Res 65:533-539 (2005).

  • Wu J, Antaki JF, Snyder TA, Wagner WR, Borovetz HS, Paden BE: Design optimization of blood shearing instrument by computational fluid dynamics. Artif Organs 29:482-489 (2005).

  • Guan J, Wagner WR: Synthesis, characterization and cytocompatibility of polyurethaneurea elastomers with designed elastase sensitivity. Biomacromolecules 6:2833-2842 (2005).

  • Wu J, Antaki JF, Wagner WR, Snyder TA, Paden BE, Borovetz HS: Elimination of adverse leakage flow in a miniature pediatric centrifugal blood pump by computational fluid dynamics-based design optimization. ASAIO J 51:636–643 (2005).

  • Weller GER, Villanueva FS, Tom E, Wagner WR: Targeted ultrasound contrast agents: In vitro assessment of endothelial dysfunction and multi-targeting to ICAM-1 and sialyl Lewisx. Biotechnol Bioeng 92:780-788 (2005).

  • Stankus JJ, Guan J, Fujimoto K, Wagner WR: Microintegrating smooth muscle cells into a biodegradable, elastomeric fiber matrix. Biomaterials 27:735–744 (2006).

  • Xu H, Kaar JL, Russell AJ, Wagner WR: Characterizing the modification of surface proteins with poly(ethylene glycol) to interrupt platelet adhesion. Biomaterials 27:3125–3135 (2006).

  • Courtney T, Sacks MS, Stankus J, Guan J, Wagner WR: Design and analysis of tissue engineered scaffolds that mimic soft tissue mechanical anisotropy. Biomaterials 27:3631-3638 (2006).

  • Guan J, Stankus JJ, Wagner WR: Development of composite porous scaffolds based on collagen and biodegradable poly(ester urethane)urea. Cell Transplant 15(S1):17-27 (2006).

  • Snyder TA, Eash HJ, Litwak KN, Frankowski BJ, Hattler BG, Federspiel WJ, Wagner WR: Blood biocompatibility assessment of an intravenous gas exchange device. Artif Organs 30:657–664 (2006).

  • Soletti L, Nieponice A, Guan J, Stankus JJ, Wagner WR, Vorp DA: A seeding device for tissue engineered tubular structures. Biomaterials 27:4863-4870 (2006).

  • Ramaswami P, Wagner WR.  Cardiovascular tissue engineering. An Introduction to Biomaterials. S.A. Guelcher and J.O. Hollinger, Eds., CRC Press, Boca Raton, FL, (2006).

  • Wearden PD, Morell VO, Keller BB, Webber SA, Borovetz HS, Badylak SF, Boston JR, Kormos RL, Kameneva MV, Simaan M, Snyder TA, Tsukui H, Wagner WR, Antaki JF, Diao C, Vandenberghe S, Gardiner J, Li CM, Noh D, Paden D, Paden B, Wu J, Bearnson GB, Jacobs G, Kirk J, Khanwilkar P, Long JW, Miles S, Hawkins JA, Kouretas PC, Shaddy RE. The PediaFlow pediatric ventricular assist device. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 9:92-98 (2006).

  • Borovetz HS, Badylak S, Boston JR, Johnson C, Kormos R, Kameneva MV, Simaan M, Snyder TA, Tsukui H, Wagner WR, Woolley J, Antaki J, Diao C, Vandenberghe S, Keller B,  Morell V, Wearden P, Webber S, Gardiner J, Li CM, Paden D, Paden B, Snyder S, Wu J, Bearnson G, Hawkins JA, Jacobs G, Kirk J, Khanwilkar P, Kouretas PC, Long J, Shaddy RE. Towards the development of a pediatric ventricular assist device. Cell Transplant. 15(S1):69-74 (2006).

  • Guan J, Stankus JJ, Wagner WR. Soft tissue scaffolds. Encyclopedia of Biomedical Engineering. G. Pins, Ed., J. Wiley and Sons (2006).

  • Snyder TA, Tsukui H, Kihara S, Akimoto T, Litwak KN, Kameneva MV, Yamazaki K, Wagner WR: Preclinical biocompatibility assessment of the EVAHEART ventricular assist device: coating comparison and platelet activation. J Biomed Mater Res A 81:85-92 (2007).

  • Fujimoto KL, Guan J, Oshima H, Sakai T, Wagner WR: In vivo evaluation of a porous, elastic, biodegradable patch for reconstructive cardiac procedures. Ann Thorac Surg 83:648-654 (2007).

  • Snyder TA, Litwak KN, Tsukui H, Akimoto T, Kihara S, Yamazaki K, Wagner WR: Leukocyte-platelet aggregates and monocyte tissue factor expression in bovines implanted with ventricular assist devices. Artif Organs 31:126-131(2007).

  • Deglau TE, Johnson JD, Villanueva FS, Wagner WR: Targeting microspheres and cells to PEG-modified biological surfaces. J Biomed Mater Res A 81:578–585 (2007).

  • Villanueva FS, Lu E, Bowry S, Kilic S, Tom E, Wang J, Gretton J, Pacella JJ, Wagner WR: Myocardial ischemic memory imaging using molecular echocardiography. Circulation 115:345-352 (2007).

  • Stankus JJ, Soletti L, Fujimoto K, Hong Y, Vorp DA, Wagner WR: Fabrication of cell microintegrated blood vessel constructs through electrohydrodynamic atomization. Biomaterials 28:2738–2746 (2007).

  • Fujimoto KL, Tobita K, Merryman WD, Guan, J, Momoi N, Stolz DB, Sacks MS, Keller BB, Wagner WR: An elastic, biodegradable cardiac patch induces contractile smooth muscle and improves cardiac remodeling and function in sub-acute myocardial infarction. J Am Coll Cardiol 49:2292-2300 (2007).

  • Guan J, Stankus JJ, Wagner WR: Biodegradable elastomeric scaffolds with basic fibroblast growth factor release. J Control Release 120:70-78 (2007).

  • Dasse KA, Gellman BN, Kameneva MV, Woolley J, Johnson C, Gempp T, Marks JD, Kent S, Koert A, Richardson JS, Franklin S, Snyder TA, Wearden P, Wagner WR, Gilbert RJ, Borovetz HS: Assessment of hydraulic performance and biocompatibility of a MagLev centrifugal pump system designed for pediatric cardiac or cardiopulmonary support. ASAIO J 53:771-777 (2007).

  • Nieponice A, Soletti L, MS, Guan J, PhD, Deasy BM, Huard J, Wagner WR, Vorp DA: Development of a tissue engineered vascular graft combining a biodegradable scaffold, muscle-derived stem cells and a rotational vacuum seeding technique. Biomaterials 29:825-833 (2008).

  • Johnson CA Jr., Snyder TA, Woolley JR, Wagner WR: Flow cytometric assays for quantifying activated ovine platelets. Artif Organs 32:136–145 (2008).

  • Stankus JJ, Freytes DO, Badylak SF, Wagner WR: Hybrid nanofibrous scaffolds from electrospinning of a synthetic biodegradable elastomer and urinary bladder matrix. J Biomater Sci Polym Ed 19:635–652 (2008).

  • Hong Y, Fujimoto K, Hashizume R, Guan J, Stankus JJ, Tobita K, Wagner WR: Generating elastic, biodegradable polyurethane/poly(lactide-co-glycolide) fibrous sheets with controlled antibiotic release via two-stream electrospinning. Biomacromolecules 9:1200-1207 (2008).

  • Guan J, Hong Y, Ma Z, Wagner WR: Protein-reactive, thermoresponsive copolymers  with high flexibility and biodegradability. Biomacromolecules 9:1283-1292 (2008).

  • Stella JA, Liao J, Hong Y, Merryman WD, Wagner WR, Sacks MS: Tissue-to-cellular level deformation coupling in cell microintegrated elastomeric scaffolds. Biomaterials 29(22):3228-36 (2008).

  • El-Kurdi MS, Hong Y, Stankus JJ, Soletti L, Wagner WR, Vorp DA: Transient elastic support for vein grafts using a constricting microfibrillar polymer wrap. Biomaterials 29(22):3213-3220 (2008).

  • Guan, J, Fujimoto, KL, Wagner WR:  Elastase-Sensitive Elastomeric Scaffolds with Variable Anisotropy for Soft Tissue Engineering.  Pharm Res (in press). 

CONTACT INFORMATION

Dr. William Wagner
Phone: (412) 624-5324
Email: wagnerwr@upmc.edu