Yoram Vodovotz, Ph.D.

Selected recent publications:

  • Luckhart, S.; Crampton, A. L.; Zamora, R.; Lieber, M. J.; Dos Santos, P. C.; Peterson, T. M. L.; Emmith, N.; Lim, J.; Wink, D. A.; Vodovotz, Y. Mammalian transforming growth factor-b1 activated after ingestion by Anopheles stephensi modulates mosquito immunity. Infect. Immun.  2003.  71:3000-3009.

  • Kumar, R.; Clermont, G.; Vodovotz, Y.; Chow, C. C. The dynamics of acute inflammation. J.Theoretical Biol.  2004. 230:145-155.

  • Clermont, G.; Bartels, J.; Kumar, R.; Constantine, G.; Vodovotz, Y.; Chow, C. In silico design of clinical trials: a method coming of age. Crit Care Med.  2004. 32:2061-2070.

  • Chow, C. C.; Clermont, G.; Kumar, R.; Lagoa, C.; Tawadrous, Z.; Gallo, D.; Betten, B.; Bartels, J.; Constantine, G.; Fink, M. P.; Billiar, T. R.; Vodovotz, Y. The acute inflammatory response in diverse shock states. Shock  2005. 24:74-84.

  • Prince, J.M.; Levy,R.M.; Bartels, J.; Baratt, A.; Kane, J.M. III; Lagoa, C.; Rubin, J.; Day, J.;  Wei, J.; Fink, M.P.; Goyert, S.; Clermont, G.;  Billiar, T.R.;  Vodovotz, Y. In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice. Mol. Med., 2006. 12:88-96.

  • Lagoa, C.E.; Bartels, J.; Baratt, A.; Tseng, G.; Clermont, G.; Fink, M.P.; Billiar, T.R.; Vodovotz, Y. The role of initial trauma in the host’s response to injury and hemorrhage: Insights from a comparison of mathematical simulations and hepatic transcriptomic analysis. Shock, 2006. 26:592-600.

  • Mi, Q.; Rivière, B.; Clermont, G.; Steed, D.L. ; Vodovotz, Y. Agent-based model of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor-b1. Wound Rep. Reg. 2007. 15:671-682.

  • Luckhart, S.; Lieber, M.; Singh, N.; Zamora, R.; Vodovotz, Y. Low levels of mammalian TGF-b1 are protective against malaria parasite infection, a paradox clarified in the mosquito host. Exp. Parasitol. 2008. 118:290-296.

  • Kumar, R.; Chow, C.C.; Bartels, J.; Clermont, G.; Vodovotz, Y. A mathematical simulation of the inflammatory response to anthrax infection. Shock. 2008. 29:104-111.

  • Bagci, E.Z.; Vodovotz, Y.; Billiar, T.R.; Ermentrout, G.B.; Bahar, I. Competing effects of nitric oxide in regulating apoptosis: insights from computational modeling. PLoS ONE. 2008. 3:e2249.

  • Li, N.Y.K.; Verdolini, K.; Clermont, G.; Mi, Q.; Hebda, P.A.; Vodovotz, Y. A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury. PLoS ONE. 2008. 3:e2789.

  • Vodovotz, Y., Csete, M.; Bartels, J.; Chang, S.; An, G. Translational systems biology of inflammation. PLoS Comput. Biol. 2008. 4:1-6.

  • Rivière, B.; Epshteyn, Y.; Swigon, D.; Vodovotz, Y. A mathematical model of signaling resulting from the binding of lipopolysaccharide with Toll-like receptor 4 demonstrates inherent preconditioning behavior. Math. Biosci 2008. (In Press).

  • Torres, A.; Bentley, T.; Bartels, J.; Namas, R.; Zamora, R.; Puyana, J.C.; Vodovotz, Y. Mathematical modeling of post-hemorrhage inflammation in mice: Studies using a novel, computer-controlled, closed-loop hemorrhage apparatus. Shock. 2008. (In Press).

CONTACT INFORMATION

Yoram Vodovotz, Ph.D.
Phone: (412) 648-3758
Email: vodovotzy@upmc.edu