At the University of Pittsburgh, Dr. Yoram Vodovotz is a Professor in the Department of Surgery with secondary appointments in the Department of Computational & Systems Biology, the Department of Bioengineering, the Department of Immunology, the Department of Communication Science and Disorders (of the School of Health and Rehabilitation Science), and the Clinical and Translational Science Institute. He also is the Director of the Center for Inflammation and Regenerative Modeling at the McGowan Institute for Regenerative Medicine.
Dr. Vodovotz received his BS degree from the University of Wisconsin-Madison; he graduated with distinction with a triple major in Biochemistry, Molecular Biology, and Genetics. In 1993 he received his PhD in Immunology from Cornell University Graduate School of Medical Sciences. In addition to post-graduate training at Cornell, he also worked at the National Institutes of Health, National Cancer Institute, in the Laboratory of Chemoprevention and the Radiation Biology Branch.
Dr. Vodovotz is a member of the Wound Healing Society, the Society for Complex Acute Illness, and the Shock Society. For his research efforts, Dr. Vodovotz has been honored most recently as the Keynote Speaker, NIH Bioinformatics Summit 2009, the IGI Globalís 4th Annual Excellence in Research Award (2011), and the 2013 Keynote Speaker, 20th Annual Charles B. Huggins Research Symposium, University of Chicago. He was also an invited speaker and a member of the organizing committee for the 12th International Conference on Complex Acute Illness, Budapest, Hungary, 2013.
Dr. Vodovotzís long-term research goals are to obtain high-dimensional, dynamic data on the etiology and progression of various inflammatory processes and diseases in samples derived from cells, animals, and people; to create computational models based on these data; and to modulate the inflammatory response in an optimal spatial, temporal, and individual- / disease-specific manner. More specifically, his research interests, carried out in the context of an interdisciplinary research team, are the following:
- Systems biology and mathematical modeling of inflammation and wound healing in various disease states, especially infection, trauma, and hemorrhage, and the application of these computational approaches to regenerative medicine and rational drug/device design
- Control of the inducible nitric oxide (NO) synthase (NOS2) by the cytokine transforming growth factor-Ŗ1 (TGF-Ŗ1) in numerous physiological and pathological settings
- Control of the activation of TGF-Ŗ1 by NO, other free radicals, and novel therapeutic agents for inflammatory conditions
- Subcellular localization of NOS2
- Modulation of inflammation in hemorrhagic shock
- Mechanisms of LPS action on hepatocytes
- Role of NO and TGF-Ŗ1 in the modulation of the pro-apoptotic protein BNIP3
Dr. Vodovotz serves as the reviewer for over 50 professional journals and has received research funding from many groups, including the NIH, DOD, American Heart Association, the Plastic Surgery Educational Foundation, the Medlantic Research Institute, and the NSF. He has over 250 publications, articles, book chapters/reviews, and abstracts.
View a list of Dr. Vodovotzís publications here.
Dr. Yoram Vodovotz
Phone: (412) 648-3758