Selected recent publications:

• Lemster BH, Michel JJ, Montag DT, Paat JJ, Studenski SA, Newman AB, Vallejo AN.
  Induction of CD56 and TCR-independent activation of T cells with aging. J Immunol. 2008 Feb 1;180(3):1979-90.
• Pilbeam K, Basse P, Brossay L, Vujanovic N, Gerstein R, Vallejo AN, Borghesi L.
  The ontogeny and fate of NK cells marked by permanent DNA rearrangements.
  J Immunol. 2008 Feb 1;180(3):1432-41.
• López de Padilla CM, Vallejo AN, McNallan KT, Vehe R, Smith SA, Dietz AB, Vuk-Pavlovic S, Reed AM. Plasmacytoid dendritic cells in inflamed muscle of patients with juvenile dermatomyositis. Arthritis Rheum. 2007 May;56(5):1658-68.
• Vallejo AN. Age-dependent alterations of the T cell repertoire and functional diversity of T cells of the aged. Immunol Res. 2006;36(1-3):221-8. Review.
• Vallejo AN. Immune remodeling: lessons from repertoire alterations during chronological aging and in immune-mediated disease. Trends Mol Med. 2007 Mar;13(3):94-102. Review.
• Michel JJ, Turesson C, Lemster B, Atkins SR, Iclozan C, Bongartz T, Wasko MC, Matteson EL, Vallejo AN. CD56-expressing T cells that have features of senescence are expanded in rheumatoid arthritis. Arthritis Rheum. 2007 Jan;56(1):43-57. Erratum in: Arthritis Rheum. 2007 Mar;56(3):830.
• Bryl E, Vallejo AN, Matteson EL, Witkowski JM, Weyand CM, Goronzy JJ. Modulation of CD28 expression with anti-tumor necrosis factor alpha therapy in rheumatoid arthritis.
  Arthritis Rheum. 2005 Oct;52(10):2996-3003.
• Abedin S, Michel JJ, Lemster B, Vallejo AN. Diversity of NKR expression in aging T cells and in T cells of the aged: the new frontier into the exploration of protective immunity in the elderly. Exp Gerontol. 2005 Jul;40(7):537-48. Review.
• Miyamae T, Malehorn DE, Lemster B, Mori M, Imagawa T, Yokota S, Bigbee WL, Welsh M, Klarskov K, Nishomoto N, Vallejo AN, Hirsch R. Serum protein profile in systemic-onset juvenile idiopathic arthritis differentiates response versus nonresponse to therapy. Arthritis Res Ther. 2005;7(4):R746-55.
• Naylor K, Li G, Vallejo AN, Lee WW, Koetz K, Bryl E, Witkowski J, Fulbright J, Weyand CM, Goronzy JJ. The influence of age on T cell generation and TCR diversity.
  J Immunol. 2005 Jun 1;174(11):7446-52.
• Vallejo AN. CD28 extinction in human T cells: altered functions and the program of T-cell senescence. Immunol Rev. 2005 Jun;205:158-69. Review.
• Xu J, Vallejo AN, Jiang Y, Weyand CM, Goronzy JJ. Distinct transcriptional control mechanisms of killer immunoglobulin-like receptors in natural killer (NK) and in T cells.
  J Biol Chem. 2005 Jun 24;280(25):24277-85.
• Braun A, Takemura S, Vallejo AN, Goronzy JJ, Weyand CM. Lymphotoxin beta-mediated stimulation of synoviocytes in rheumatoid arthritis. Arthritis Rheum. 2004 Jul;50(7):2140-50.
• Lewis DE, Merched-Sauvage M, Goronzy JJ, Weyand CM, Vallejo AN. Tumor necrosis factor-alpha and CD80 modulate CD28 expression through a similar mechanism of T-cell receptor-independent inhibition of transcription. J Biol Chem. 2004 Jul 9;279(28):29130-8. Epub 2004 May 5.
• Vallejo AN, Weyand CM, Goronzy JJ. T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection. Trends Mol Med. 2004 Mar;10(3):119-24. Review.

CONTACT INFORMATION

Abbe N. de Vallejo PhD
Phone: (412) 692-8455
Email: andv26@pitt.edu