Selected recent publications:

• Bobick BE, Matsche AI, Chen FH, Tuan RS.  The ERK5 and ERK1/2 signaling pathways play opposing regulatory roles during chondrogenesis of adult human bone marrow-derived multipotent progenitor cells.  Journal of Cellular Physiology.  2010 Jul;224(1):178-86.
• Nöth U, Rackwitz L, Steinert AF, Tuan RS.  Cell delivery therapeutics for musculoskeletal regeneration.  Advanced Drug Delivery Reviews.  2010 Jun 15;62(7-8):765-783.  Epub 2010 Apr 14.
• Alexander PG, Tuan RS.  Role of environmental factors in axial skeletal dysmorphogenesis.  Birth Defects Research Part C, Embryo Today.  2010 Jun 11;90(2):118-132.  [Epub ahead of print]
• Li J, Chen Y, Mak AF, Tuan RS, Li L, Li Y.  A one-step method to fabricate PLLA scaffolds with deposition of bioactive hydroxyapatite and collagen using ice-based microporogens.  Acta Biomaterialia.  2010 Jun;6(6):2013-9.  Epub 2009 Dec 11.
• Jackson WM, Nesti LJ, Tuan RS.  Potential therapeutic applications of muscle-derived mesenchymal stem and progenitor cells.  Expert Opinions on Biological Therapy.  2010 Apr;10(4):505-17.
• Petrie Aronin CE, Tuan RS.  Therapeutic potential of the immunomodulatory activities of adult mesenchymal stem cells.  Birth Defects Research Part C, Embryo Today.  2010 Mar;90(1):67-74.
• Bergin PF, Doppelt JD, Hamilton WG, Mirick GE, Jones AE, Sritulanondha S, Helm JM, Tuan RS.  Detection of periprosthetic infections with use of ribosomal RNA-based polymerase chain reaction.  Journal of Bone and Joint Surgery, American.  2010 Mar;92(3):654-63.
• Kuhn NZ, Tuan RS.  Regulation of stemness and stem cell niche of mesenchymal stem cells: implications in tumorigenesis and metastasis.  Journal of Cell Physiology.  2010 Feb;222(2):268-77.  Review.
• Huang GT, Yamaza T, Shea LD, Djouad F, Kuhn NZ, Tuan RS, Shi S.  Stem/Progenitor cell-mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model.  Tissue Engineering Part A.  2010 Feb;16(2):605-15.
• Bobick BE, Tuan RS, Chen FH.  The intermediate filament vimentin regulates chondrogenesis of adult human bone marrow-derived multipotent progenitor cells.  Journal of Cell Biochemistry.  2010 Jan 1;109(1):265-76.
• Maher SA, Mauck RL, Rackwitz L, Tuan RS.  A nanofibrous cell-seeded hydrogel promotes integration in a cartilage gap model.  Journal of Tissue Engineering and Regenerative Medicine.  2010 Jan;4(1):25-9.
• Bobick BE, Chen FH, Le AM, Tuan RS.  Regulation of the chondrogenic phenotype in culture.  Birth Defects Research Part C, Embryo Today.  2009 Dec;87(4):351-71.  Review.
• Jackson WM, Aragon AB, Bulken-Hoover JD, Nesti LJ, Tuan RS.  Putative heterotopic ossification progenitor cells derived from traumatized muscle.  Journal of Orthopaedic Research.  2009 Dec;27(12):1645-51.
• Huang AH, Stein A, Tuan RS, Mauck RL.  Transiant exposure to TGF-beta3 improves the mechanical properties of MSC-laden cartiledge constructs in a density dependent manner.  Tissue Engineering Part A.  2009 Nov;15(11):3461-72.
• Pricola KL, Kuhn NZ, Haleem-Smith H, Song Y, Tuan RS.  Interleukin-6 maintains bone marrow-derived mesenchymal stem cell stemness by an ERK1/2-dependent mechanism.  Journal of Cellular Biochemistry.  2009 Oct 15;108(3):577-88.
• Djouad F, Rackwitz L, Song Y, Janjanin S, Tuan RS.  ERK1/2 activation induced by inflammatory cytokines compromises effective host tissue integration of engineered cartilage.  Tissue Engineering Part A.  2009 Oct;15(10):2825-35.
• Tsai MT, Li WJ, Tuan RS, Chang WH.  Modulation of osteogenesis in human mesenchymal stem cells by specific pulsed electromagnetic field stimulation.  Journal of Orthopaedic Research.  2009 Sep;27(9):1169-74.
• Lozito TP, Kuo CK, Taboas JM, Tuan RS.  Human mesenchymal stem cells express vascular cell phenotypes upon interaction with endothelial cell matrix.  Journal of Cellular Biochemistry.  2009 Jul 1;107(4):714-22.
• Lozito TP, Taboas JM, Kuo CK, Tuan RS.  Mesenchymal stem cell modification of endothelial matrix regulates their vascular differentiation.  Journal of Cellular Biochemistry.  2009 Jul 1;107(4):706-13.
• Mauck RL, Baker BM, Nerurkar NL, Burdick JA, Li WJ, Tuan RS, Elliott DM.  Engineering on the straight and narrow: the mechanics of nanofibrous assemblies for the fiber-reinforced tissue regeneration.  Tissue Engineering Part B Reviews.  2009 Jun;15(2):171-93.
• Li WJ, Tuan RS.  Fabrication and application of nanofibrous scaffolds in tissue engineering.  Current Protocols in Cell Biology.  2009 Mar;Chapter 25:Unit 25.2.
• Jackson WM, Aragon AB, Djouad F, Song Y, Koehler SM, Nesti LJ, Tuan RS.  Mesenchymal progenitor cells derived from traumatized human muscle.  Journal of Tissue Engineering and Regenerative Medicine.  2009 Feb;3(2):129-38.
• Wang X, Song Y, Jacobi JL, Tuan RS.  Inhibition of histone deacetylases antagonized FGF2 and IL-1beta effects on MMP expression in human articular chondrocytes.  Growth Factors.  2009 Feb;27(1):40-9.
• Korecki CL, Kuo CK, Tuan RS, Iatridis JC.  Intervertebral disc cell response to dynamic compression is age and frequency dependent.  Journal of Orthopaedic Research.  2009 Jun;27(6):800-6.
• Li WJ, Chiang H, Kuo TF, Lee HS, Jiang CC, Tuan RS.  Evaluation of articular cartilage repair using biodegradable nanofibrous scaffolds in a swine model: a pilot study.  Journal of Tissue Engineering and Regenerative Medicine.  2009 Jan;3(1):1-10.
• Nesti LJ, Jackson WM, Shanti RM, Koehler SM, Aragon AB, Bailey JR, Sracic MK, Freedman BA, Giuliani JR, Tuan RS.  Differentiation potential of multipotent progenitor cells derived from war-traumatized muscle tissue.  Journal of Bone and Joint Surgery American.  2008 Nov;90(11):2390-8.
• Shanti RM, Janjanin S, Li WJ, Nesti LJ, Mueller MB, Tzeng MB, Tuan RS.  In vitro adipose tissue engineering using an electrospun nanofibrous scaffold.  Annals of Plastic Surgery.  2008 Nov;61(5):566-71.
• Chen FH, Tuan RS.  Mesenchymal stem cells in arthritic diseases.  Arthritis Research and Therapy.  2008;10(5):223.  Epub 2008 Oct 10.  Review.
• Shanti RM, Janjanin S, Li WJ, Nesti LJ, Mueller MB, Tzeng MB, Tuan RS.  In vitro adipose tissue engineering using an electrospun nanofibrous scaffold.  Annals of Plastic Surgery.  2008 Nov;61(5):566-71.
• Kuo CK, Tuan RS.  Mechanoactive tenogenic differentiation of human mesenchymal stem cells.  Tissue Engineering Part A.  2008 Oct;14(10):1615-27.
• Nesti LJ, Li WJ, Shanti RM, Jiang YJ, Jackson W, Freedman BA, Kuklo TR, Giuliani JR, Tuan RS.  Intervertebral disc tissue engineering using a novel hyaluronic acid-nanofibrous scaffold (HANFS) amalgam.  Tissue Engineering Part A.  2008 Sep;14(9):1527-37.
• Tuan RS, Lee FY, T Konttinen Y, Wilkinson JM, Smith RL; Implant Wear Symposium 2007 Biologic Work Group.  What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles?  Journal of the American Academy of Orthopaedic Surgeons.  2008;16 Suppl 1:S42-8.
• Janjanin S, Djouad F, Shanti RM, Baksh D, Gollapudi K, Prgomet D, Rackwitz L, Joshi AS, Tuan RS.  Human palatine tonsil: a new potential tissue source of multipotent mesenchymal progenitor cells.  Arthritis Research and Therapy.  2008;10(4):R83.  Epub 2008 Jul 28.
• Byers BA, Mauck RL, Chiang IE, Tuan RS.  Transient exposure to transforming growth factor beta 3 under serum-free conditions enhances the biomechanical and biochemical maturation of tissue-engineered cartilage.  Tissue Engineering Part A.  2008 Nov;14(11):1821-34.

CONTACT INFORMATION

Dr. Rocky Tuan
Phone: (412) 648-2222
Email: rst13@pitt.edu