Selected recent publications:

• Marigliano M, Casu A, Bertera S, Trucco M, Bottino R:  Hemoglobin A1C percentage in non-human primates:  a useful tool to monitor diabetes before and after porcine pancreatic islet xenotransplantation.  J Transplantation, In press, 2011.
• Stefan M, Simmons RA, Bertera S, Trucco M, Esni F, Drain P, Nicholls RD:  Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome. Am J Physiol Endocrinol Metab, In press, 2011.
• Selivanov VA, Votyakova TV, Pivtoraiko V, Zeak JA, Sukhomlin T, Trucco M, Roca J, Cascante M:  Reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain. PLoS Computational Biology, In press, 2011.
• Cifarelli V, Trucco M, Luppi P:  Anti-inflammatory effects of C-peptide prevent endothelial dysfunction in type 1 diabetes.  Immun Endoc & Metab Agents in Med Chem, In press, 2011.
• Di Caro V, D’Anneo A, Phillips B, Engman C, Harnaha J, Lakomy R, Styche A, Trucco M, Giannoukakis N:  IL-7 matures suppressive CD127+ Foxp3+ T-cells into CD127- CD25HIGH Foxp3+ Tregs. Clin Exp Immunol, In press, 2011.
• Coudriet GM, He J, Trucco M, Mars WM, Piganelli JD:  Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages:  implications for inflammatory mediated diseases. PLoS ONE 5(11): e15384, 2010.
• Crossett A, Kent BP, Klei L, Ringquist S, Trucco M, Roeder K, Devlin B:  Using ancestry matching to combine family-based and unrelated samples for genome-wide association studies.  Statistics in Medicine DOI:10.1002/sim.4057, 2010.
• Trucco M: Beta-cell regeneration: From science fiction to challenging reality. Pediatric Diabetes 11:292, 2010.
• Morran MP, Casu A, Arena VC, Pietropaolo S, Zhang YJ, Satin LS, Nelson P, Omenn GS, Trucco M, Becker DJ, Pietropaolo M.  Humoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen IA-2 heightens the risk of type 1 diabetes.  Endocrinology.  2010 Jun;151(6):2528-37.  Epub 2010 Apr 9.
• Schulte BM, Kramer M, Ansems M, Lanke KH, van Doremalen N, Piganelli JD, Bottino R, Trucco M, Galama JM, Adema GJ, van Kuppeveld FJ.  Phagocytosis of enterovirus-infected pancreatic beta-cells triggers innate immune responses in human dendritic cells.  Diabetes.  2010 May;59(5):1182-91.  Epub 2010 Jan 13.
• Sklavos MM, Bertera S, Tse HM, Bottino R, He J, Beilke JN, Coulombe MG, Gill RG, Crapo JD, Trucco M, Piganelli JD.  Redox Modulation Protects Islets from Transplant-related Injury.  Diabetes.  2010 Apr 22.  [Epub ahead of print]
• van der Windt DJ, Smetanka C, Macedo C, He J, Lakomy R, Bottino R, Ekser B, Echeverri GJ, Metes D, Ijzermans JN, Trucco M, Cooper DK, Lakkis FG.  Investigation of lymphocyte depletion and repopulation using alemtuzumab (Campath-1H) in cynomolgus monkeys.  American Journal of Transplantation.  2010 Apr;10(4):773-83.
• Wu J, Devlin B, Ringquist S, Trucco M, Roeder K.  Screen and clean: a tool for identifying interactions in genome-wide association studies.  Genetic Epidemiology.  2010 Apr;34(3):275-85.
• Potter KJ, Abedini A, Marek P, Klimek AM, Butterworth S, Driscoll M, Baker R, Nilsson MR, Warnock GL, Oberholzer J, Bertera S, Trucco M, Korbutt GS, Fraser PE, Raleigh DP, Verchere CB.  Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts.  Proceedings of the National Academy of Sciences U S A.  2010 Mar 2;107(9):4305-10.  Epub 2010 Feb 16.
• van der Windt DJ, Bottino R, Casu A, Campanile N, Smetanka C, He J, Murase N, Hara H, Ball S, Loveland BE, Ayares D, Lakkis FG, Cooper DK, Trucco M.  Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets.  American Journal of Transplantation.  2009 Dec;9(12):2716-26.  Epub 2009 Oct 21.

CONTACT INFORMATION

Dr. Massimo Trucco
Phone: (412) 692-6570
Email: mnt@pitt.edu