Stephen C. Strom, Ph.D.
Selected recent publications:

  • Strom, SC , Fisher, RA, (2003) Hepatocyte Transplantation: New possibilities for therapy. Gastroenterology 124: 568-571.
  • Horslen, SP, McCowan, T.C., Goertzen, T.C., Warkington, P.I., Cai, H., Strom, S.C., and Fox, I.J. (2003) Isolated hepatocyte transplantation in an infant with a severe urea cycle disorder. Pediatrics 111: 1262 – 1267.
  • Kostrubsky, V.E., Strom, S.C., Hanson, J., Urda, E., Rose, K., Burleigh, J., Zocharski, P.,Cai, H., Sinclair, J.F. and Sahi, J. (2003). Evaluation of the hepatotoxic potential of drugs by inhibition of bile acid transport in cultured primary human hepatocytes and intact rats. Toxicol. Sci. 76: 220-228.
  • Wege, H., Chui, M.S., Le, H.T., Cai, H., Strom, S.C. and Zern, M.A. (2003) In vitro expansion of human hepatocytes is restricted by telomere-dependent replicative aging. Cell Transplantation 12:897-906.
  • Lamba, V., Lamba, J. Strom, S. Davila, J., Hancock, M, Yang, W., Frackenthal, J.D., Rosan, P., Ring, B., Wrighton, S. and Schuetz, E.G. (2004) Hepatic CYP2B6 expression: gender and population differences in relationship to CYP2B6 genotype and CAR expression. J Pharmacol Exp Ther. 307: 906-922.
  • Davila, J.C., Thiede, M., Strom, SC, Miki, T., Cezar, G. Cosma, G, and Trosko, J (2004) Use and application of stem cells in toxicology. Toxicol Sci 79: 214-223.
  • Assem, M, Schuetz, EG, Leggas, M, Sun, D, Yasuda, K, Reid, G, Zelcers, N, Adachi, M, Strom, S, Evans, R, Moore, D, Borst, P, Schuetz, JD. (2004) Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J. Biol Chem. 279: 22250-22257.
  • Komorosky, B.J., Zang, S., Cai, H. Hutzler, M., Fry, R., Tracy, T., Strom, S.C., Venkararamanan, R., (2004) Induction and inhibition by St. John’s Wort constituent hyperforin in human hepatocytes. Drug Metab Disp. 32: 512-518.
  • Walldorf, J., Aurich H, Cai, H, Runge, D., Christ, B, Strom S.C., Fleig, W. (2004) Donor age dependent proliferative capacity of cultured human hepatocytes. Scan. J. Gastroenterol. 39: 584-593.
  • Lamba, V., Yasuda, K., Lamba, J., Cline, C., Assem, M., Lin, Y., Davila, J., Strom, S and Schuetz, E.G. PXR/SXR (NR1I2): Splice variants in human tissues including brain and the functional consequence of the major splice variant. (In Press, Tox. Applied Pharmacol.
  • Wu, MH, Chen, P, Wu, X, Strom, S, Das, S, Cook, EH, Dolan, ME. (2004) Detrmination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxyesterase 2 gene. Pharmacogenetics. (In Press)

CONTACT INFORMATION

Dr. Stephen Strom
Phone: (412) 624-7715
Email: strom@pitt.edu