Stephen Strom, Ph.D., is a Professor - Division of Cellular and Molecular Pathology at the University of Pittsburgh. His primary research interests include chemical carcinogenesis and molecular mechanisms of growth control. His primary research interests include chemical carcinogenesis and molecular mechanisms of growth control in human liver and prostate. Within his laboratory, there are two main programs under development. Under the direction of Dr. Strom, a research team is currently investigating the progression of cancer within the liver and the regulation of human gene expression.
Dr. Strom has been featured in several publications for his research efforts regarding the human liver. He has recently been recognized for his work in investigating the role of growth factors and growth factor receptor systems in the development and progression of cancer. Recent results indicate that the expression of new growth factor pathways and the communication between existing growth factor pathways are two mechanisms by which growth control regulation is lost in cancer development. In other studies, researchers have determined that the regulation of the expression of the cytochrome P450 genes in human liver is strikingly different from that observed in animal models. It has recently been identified the ethanol is a potent inducer of the CYP3A family of human genes. The induction of CYP3A by ethanol is most likely the basis for adverse effects of ethanol consumption on acetaminophen toxicity in humans. Current studies involving the examination of the promoter sequences of the human P450 genes have identified several regions of the DNA, to which protein binding can be demonstrated, which are thought to control gene expression.
Dr. Stephen Strom
Phone: (412) 624-7715