David H. Perlmutter, M.D.

Dr. David Perlmutter is a Vira I. Heinz Professor and Chairman of Pediatrics at the University of Pittsburgh where he teaches Cell Biology and Physiology in the School of Medicine. Additionaly, Dr. Perlmutter is the Physician-in-Chief and Scientific Director of Children's Hospital of Pittsburgh Rangos Research Center. He holds a B.A. in Psychology form the University of Rochester, and received his M.D. from St. Louis University School of Medicine in 1978. After graduating, Dr. Perlmutter completed his Residency in Pediatrics at Children's Hospital of Philadelphia, PA, in1979, and followed through with a Fellow in Medicine (Gastroenterology & Nutrition) at Children's Hospital, Boston, MA.

Before joining the faculty of the university, Dr. Perlmutter held several prestigious positions in the field of pediatrics. His professional experiences immediately prior to coming to Pittsburgh include holding the positions of Donald Strominger Chair and Professor in Pediatrics, as well as Professor of Cell Biology and Physiology, at Washington University School of Medicine, and Director of the Division of Gastroenterology and Nutrition at St. Louis Children's Hospital. At the present time, Dr. Perlmutter serves on the editorial boards of Hepatology and the American Journal of Physiology, and as a consulting editor of Pediatric Research, while remaining an active faculty member and research participant at the university.

Dr. Perlmutter has been featured in several publications for his most recent research regarding disorders of infancy, childhood and adolescence. Primarily, his efforts have focused on liver, lung and gastroenterological diseases. The projects in which Dr. Perlmutter is currently involved include the following:

  • Local Expression of Alpha-1-Antitrypsin in Emphysema
  • ER Retention in Alpha-1-Antitrypsin Deficiency
  • Stem Cell Biology and Therapeutics Center
  • Iminosugars for treatment of antitrypsin deficiency
  • General Clinical Research Center
  • Genomic Analysis of the Cellular Response in Alpha-1-Antitrypsin Deficiency
  • The Clinical Interface of Molecular and Cellular Biology
  • Biliary Atresia Clinical Research Consortium: Pittsburgh


Dr. David H. Perlmutter
Phone: (412) 692-8071
Email: David.Perlmutter@chp.edu