Selected recent publications:

• Vazquez A, Oltvai ZN. Molecular crowding defines a common origin for the warburg effect in proliferating cells and the lactate threshold in muscle physiology. PLoS ONE [Internet]. 2011;6(4)
• Le H-, Oltvai ZN, Bar-Joseph Z. Cross-species queries of large gene expression databases. Bioinformatics [Internet]. 2010;26(19):2416-23.
• Henriksen ST, Liu J, Estiu G, Oltvai ZN, Wiest O. Identification of novel bacterial histidine biosynthesis inhibitors using docking, ensemble rescoring, and whole-cell assays. Bioorganic and Medicinal Chemistry [Internet]. 2010;18(14):5148-56.
• Vazquez A, Liu J, Zhou Y, Oltvai ZN. Catabolic efficiency of aerobic glycolysis: The warburg effect revisited. BMC Systems Biology [Internet]. 2010;4
• Shen Y, Liu J, Estiua G, Isin B, Ahn Y-, Lee D-, Barabási A-, Kapatral V, Wiest O, Oltvai ZN. Blueprint for antimicrobial hit discovery targeting metabolic networks. Proc Natl Acad Sci U S A [Internet]. 2010;107(3):1082-7.
• Tegnér JN, Compte A, Auffray C, An G, Cedersund G, Clermont G, Gutkin B, Oltvai ZN, Stephan KE, Thomas R, Villoslada P. Computational disease modeling - fact or fiction? BMC Systems Biology [Internet]. 2009;3
• Lee D-, Burd H, Liu J, Almaas E, Wiest O, Barabási A-, Oltvai ZN, Kapatral V. Comparative genome-scale metabolic reconstruction and flux balance analysis of multiple staphylococcus aureus genomes identify novel antimicrobial drug targets. J Bacteriol [Internet]. 2009;191(12):4015-24.
• Vazquez A, De Menezes MA, Barabási A-, Oltvai ZN. Impact of limited solvent capacity on metabolic rate, enzyme activities, and metabolite concentrations of S. cerevisiae glycolysis. PLoS Computational Biology [Internet]. 2008;4(10)
• Lee D-, Park J, Kay KA, Christakis NA, Oltvai ZN, Barabási A-. The implications of human metabolic network topology for disease comorbidity. Proc Natl Acad Sci U S A [Internet]. 2008;105(29):9880-5.
• Ernst J, Beg QK, Kay KA, Balázsi G, Oltvai ZN, Bar-Joseph Z. A semi-supervised method for predicting transcription factor-gene interactions in escherichia coli. PLoS Computational Biology [Internet]. 2008;4(3)
• Vazquez A, Beg QK, deMenezes MA, Ernst J, Bar-Joseph Z, Barabási A-, Boros LG, Oltvai ZN. Impact of the solvent capacity constraint on E. coli metabolism. BMC Systems Biology [Internet]. 2008;2
• Beg QK, Vazquez A, Ernst J, De Menezes MA, Bar-Joseph Z, Barabási A-, Oltvai ZN. Intracellular crowding defines the mode and sequence of substrate uptake by escherichia coli and constrains its metabolic activity. Proc Natl Acad Sci U S A [Internet]. 2007;104(31):12663-8.
• Balázsi G, Oltvai ZN. A pitfall in series of microarrays: The position of probes affects the cross-correlation of gene expression profiles; 2007. 153 p.
• Albert R, Oltvai ZN. Shaping specificity in signaling networks. Nat Genet [Internet]. 2007;39(3):286-7.
• Farkas IJ, Wu C, Chennubhotla C, Bahar I, Oltvai ZN. Topological basis of signal integration in the transcriptional-regulatory network of the yeast, saccharomyces cerevisiae. BMC Bioinformatics [Internet]. 2006;7

CONTACT INFORMATION

Zoltan Nagy Oltvai, MD
Phone: (412) 383-7408
Email: oltvai@pitt.edu