Selected recent publications

• Dawes J, Liu B, Mars W, Michalopoulos G, Khillan JS. Multiple ovarian transplants to rescue a transgenic line of mice. Lab Anim (NY). 2010 Jun;39(6):191-3. PubMed PMID: 20485359.
• Hidvegi T, Ewing M, Hale P, Dippold C, Kemp CB, Maurice N, Mukherjee A, Goldbach C, Watkins S, Michalopoulos G, Perlmutter DH. An Autophagy-Enhancing Drug Promotes Degradation of Mutant {alpha}1-Antitrypsin Z and Reduces Hepatic Fibrosis. Science. 2010 Jun 3. [Epub ahead of print] PubMed PMID: 20522742.
• Han YC, YU UP, Nelson J., Wu C, Wang H, Michalopoulos GK, Luo JH.  Interaction of Integrin-Linked Kinase and Miniature Chromosome Maintenance 7-Mediating Integrin (alpha) 7 Induced Cell Growth Suppression.  Cancer Res. 2010 June 1:70(11):4375-84.
• Paranjpe S., Bowen WC, Tseng GC, Luo JH, Orr A., Michalopoulos GK.  RNA Interference Against
  Hepatic Epidermal Growth Factor Receptor Has Suppressive Effects on Liver Regeneration in Rats.
  Am. J. Pathol. 2010 June;176(6):2669-81.
• Michalopoulos GK.  Liver regeneration after partial hepatectomy: critical analysis        of mechanistic dilemmas. Am J Pathol. 2010 Jan;176(1):2-13. Epub 2009 Dec
• Donthamsetty S, Bowen W, Mars W, Bhave V, Luo JH, Wu C, Hurd J, Orr A, Bell A, Michalopoulos G.  Liver-specific ablation of integrin-linked kinase in mice results in enhanced and prolonged cell proliferation and hepatomegaly after phenobarbital administration.  Toxicol Sci. 2010 Feb;113(2):358-66. Epub 2009 Nov 17.PMID:
• Bae MH, Bissonette GB, Mars WM, Michalopoulos GK, Achim CL, Depireux   DA, Powell EM.  Hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility.  Exp Neurol. 2010 Jan;221(1):129-35. Epub 2009 Oct 22.
• Michalopoulos GK. Liver regeneration: Alternative epithelial pathways.  Int J Biochem Cell Biol. 2009 Sep 27. [Epub ahead of print]PMID:
• Tseng GC, Cheng C, Yu YP, Nelson J, Michalopoulos G, Luo JH.  Investigating Multi-cancer Biomarkers and Their Cross-predictability in the    Expression Profiles of     Multiple Cancer Types. Biomark Insights. 2009 May 1;4:57-79.PMID: 19652763 [PubMed - in process]
• Apte U, Gkretsi V, Bowen WC, Mars WM, Luo JH, Donthamsetty S, Orr A, Monga SP, Wu C, Michalopoulos GK.  Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase.  Hepatology. 2009 Sep;50(3):844-51.PMID: 19575460
• Liu B, Paranjpe S, Bowen WC, Bell AW, Luo JH, Yu YP, Mars WM, Michalopoulos GK.  Investigation of the role of glypican 3 in liver regeneration and hepatocyte proliferation.  Am J Pathol. 2009 Aug;175(2):717-24. Epub 2009 Jul 2.PMID: 19574424
• Gretsi V, Apte, U., Mars, WM, bowen, WC, Luo, JH, Yang, Y., Yu, YP, Orr, A., St.-Arnaud, R., Dedhar, S., Kaestner,K.H., Wu, C., Michalopoulos, GK.  Liver-specific Ablation of Integrin-linked in Mice Results in Abnormal Histology, Enhanced Cell Proliferation and Hepatomegaly.  Hepatology 2008 Dec;48(6):1932-41.
• Limaye, P.b., Alarcon, G., Walls, A.., Nalesnik, M.A., Michalopoulos, G.K., Demetris, A.J., Ochoa, E.R.  Expression of Specific Hepatocyte and Cholangiocyte Transcription Factors in Human Liver Disease and Embryonic Development.  Lab Invest. 2008, August;88(8):865-72. 
• Han, C., Bowen, WC, Michalopoulos, GK, Wu, T.  Alpha-1 adrenergic receptor transactivates signal transducer and activator of transcription-3 (Stat3) through activation of Src and epidermal growth factor receptor (EGFR) in hepataocytes.  J. Cell Physiol. 2008 Aug;216(2) 486-97.
• Giannopoulos, M., Dai, C., Tan, X., Wen, S., Michalopoulos, G.K,, Liu, Y.  Hepatocyte growth factor exerts its anti-inflammatory Action by Distrupting Nuclear Factor-kappaB Signaling.  Am. J. Pathol. 2008 Jul;173(1):30-41. 

CONTACT INFORMATION

Dr. George K. Michalopoulos
Phone: (412) 648-1040
Email: michalopoulosgk@msx.upmc.edu