Selected recent publications:

• Shusterma V, McTiernan CF, Mehd Hi, Troy WC, London B. Circadian Pattern to Arrhythmias in a Genetic Mouse Model of Heart Failure. Computers in Cardiology, 36, 2009 (in press)
• Shusterman V, McTiernan CF, Goldberg A, Saba S, Salama G, London B. Adrenergic stimulation promotes T-wave alternans and arrhythmia inducibility in a TNF-alpha genetic mouse model of congestive heart failure. Am J Physiol Heart Circ Physiol. 298:H440-50, 2010
• McGaffin, KR, Moravec CA,  McTiernan CF. Leptin signaling in the failing and mechanically unloaded human heart. Circ Heart Fail. 2:676-83, 2009
• Kliment CR, Suliman HB, Tobolewski JM, Reynolds CM, Day BJ, Zhu X, McTiernan CF, McGaffin KR, Piantadosi CA, Oury TD. Extracellular superoxide dismutase regulates cardiac function and fibrosis. J Mol Cell Cardiol. 47(5):730-42, 2009
• McGaffin KR, Zou B, McTiernan CF, O'Donnell CP. Leptin attenuates cardiac apoptosis after chronic ischaemic injury. Cardiovasc Res.15:83(2):313-24, 2009.
• Ota T, Gilbert TW, Schwartzman D, McTiernan CF, Kitajima T, Ito Y, Sawa Y, Badylak SF, Zenati MA. A fusion protein of hepatocyte growth factor enhances reconstruction of myocardium in a cardiac patch derived from porcine urinary bladder matrix. J Thorac Cardiovasc Surg. 2008 Nov;136:1309-17
• McGaffin KR, Sun CK, Rager JJ, Romano LC, Zoub B, Mathier MA, O’Doherty RM, McTiernan CF, O’Donnell CP. Leptin Signaling Reduces the Severity of Cardiac Dysfunction and Remodeling after
  Chronic Ischemic Injury. Card Res 77:54-63, 2008
• Volonte D, McTiernan CF, Drab M, Kasper M, Galbiati F.Caveolin-1 and caveolin-3 form hetero-oligomeric complexes in atrial cardiac myocytes which are required for doxorubicin-induced apoptosis. Am J Physiol. 294:H392-401, 2008
• McTiernan CF, Mathier MA, Zhu X, Xiao X, Klein E, Swan CH, Mehdi H, Gibson G, Trichel AM, Glorioso JC, Feldman AM, McCurry KR, London B. Myocarditis following adeno-associated viral gene expression of human soluble TNF receptor (TNFRII-Fc) in baboon hearts. Gene Ther. 14(23):1613-22, 2007
• Inagaki K, Fuess  S,  Storm TA, Gibson GA, McTiernan CF, Mark A. Kay MA, Nakai H. Robust systemic transduction with AAV8 and AAV9 vectors in mice: similar albeit distinct transduction in several tissues specifically in the heart. Mol Ther. 14:45-53, 2006
• Mori S, Gibson G, McTiernan CF. Differential expression of MMPs and TIMPs in moderate and severe heart failure in a transgenic model. J Cardiac Failure 2006 12:314-25
• Higuchi Y, Chan TO, Brown MA, Zhang J, Degeorge Jr BR, Funakoshi H, Gibson G, McTiernan CF, Kubota T, Jones WK, Feldman AM.  Cardioprotecton Afforded by NFkB Ablation Is Associated with Activation of Akt In Mice Over-Expressing TNFa. Am J Physiol 290:H590-8, 2006

CONTACT INFORMATION

Dr. Charles McTiernan
Phone: (412) 648-3016
Email: mctiernanc@msx.upmc.edu