Selected Recent Publications:

• van Vlerken LE, Duan Z, Little SR, Seiden MV, Amiji MM.  Augmentation of therapeutic efficacy in drug-resistant tumor models using ceramide coadministration in temporal-controlled polymer-blend nanoparticle delivery systems.  AAPS Journal.  2010 Jun;12(2):171-80.  Epub 2010 Feb 9.
• Brito LA, Chandrasekhar S, Little SR, Amiji MM.  In vitro and in vivo studies of local arterial gene delivery and transfection using lipopolyplexes-embedded stents.  Journal of Biomedical Materials Research Part A. 2010 Apr;93(1):325-36.    
• Kokai LE, Tan H, Jhunjhunwala S, Little SR, Frank JW, Marra KG.  Protein bioactivity and polymer orientation is affected by stabilizer incorporation for double-walled microspheres.  Journal of Controlled Release.  2010 Jan 25;141(2):168-76.  Epub 2009 Sep 11.
• Rothstein SN, Federspiel WJ, Little SR.  A unified mathematical model for the prediction of controlled release from surface and bulk eroding polymer matrices.  Biomaterials.  2009 Mar;30(8):1657-64.  Epub 2008 Dec 19.
• Yadav S, van Vlerken LE, Little SR, Amiji MM.  Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells.  Cancer Chemotherapy and Pharmacology.  2009 Mar;63(4):711-22.  Epub 2008 Jul 11.
• Jhunjhunwala S, Raimondi G, Thomson AW, Little SR.  Delivery of rapamycin to dendritic cells using degradable microparticles.  Journal of Controlled Release.  2009 Feb 10;133(3):191-7.  Epub 2008 Oct 26.
• van Vlerken LE, Duan Z, Little SR, Seiden MV, Amiji MM.  Biodistribution and pharmacokinetic analysis of Paclitaxel and ceramide administered in multifunctional polymer-blend nanoparticles in drug resistant breast cancer model.  Molecular Pharmaceutics.  2008 Jul-Aug;5(4):516-26.  Epub 2008 Jul 11.

CONTACT INFORMATION

Dr. Steven R. Little
Phone: (412) 624-9614
Fax:     (412) 624-9639
Office:  1237 Benedum Hall / 5057 BST3
Email: srlittle@.pitt.edu