Johnny Huard, Ph.D.
Selected recent publications:
- Cooper GM, Mooney MP, Gosain AK, Campbell PG, Losee JE, Huard J. Testing the critical size in calvarial bone defects: revisiting the concept of a critical-size defect. Plastic and Reconstructive Surgery. 2010 Jun;125(6):1685-92.
- Clause KC, Tinney JP, Liu LJ, Gharaibeh B, Huard J, Kirk JA, Shroff SG, Fujimoto KL, Wagner WR, Ralphe JC, Keller BB, Tobita K. A three-dimensional gel bioreactor for assessment of cardiomyocyte induction in skeletal muscle-derived stem cells. Tissue Engineering Part C. Methods. 2010 Jun;16(3):375-85.
- Cooper GM, Miller ED, Decesare GE, Usas A, Lensie EL, Bykowski MR, Huard J, Weiss LE, Losee JE, Campbell PG. Inkjet-based biopatterning of bone morphogenetic protein-2 to spatially control calvarial bone formation. Tissue Engineering Part A. 2010 May;16(5):1749-59.
- Nieponice A, Soletti L, Guan J, Hong Y, Gharaibeh B, Maul TM, Huard J, Wagner WR, Vorp DA. In vivo assessment of a tissue-engineered vascular graft combining a biodegradable elastomeric scaffold and muscle-derived stem cells in a rat model. Tissue Engineering Part A. 2010 Apr;16(4):1215-23.
- Tang Y, Cummins J, Huard J, Wang B. AAV-directed muscular dystrophy gene therapy. Expert Opinion on Biological Therapy. 2010 Mar;10(3):395-408. Review.
- Stellos K, Kopf S, Paul A, Marquardt JU, Gawaz M, Huard J, Langer HF. Platelets in regeneration. Seminars in Thrombosis and Hemostosis. 2010 Mar;36(2):175-84. Epub 2010 Apr 22.
- Ambrosio F, Ferrari RJ, Distefano G, Plassmeyer JM, Carvell GE, Deasy BM, Boninger ML, Fitzgerald GK, Huard J. The synergistic effect of treadmill running on stem-cell transplantation to heal injured skeletal muscle. Tissue Engineering Part A. 2010 Mar;16(3):839-49.
- Chen CW, Montelatici E, Crisan M, Corselli M, Huard J, Lazzari L, Péault B. Perivascular multi-lineage progenitor cells in human organs: regenerative units, cytokine sources or both? Cytokine and Growth Factor Reviews. 2009 Oct-Dec;20(5-6):429-34. Review.
- Deasy BM, Feduska JM, Payne TR, Li Y, Ambrosio F, Huard J. Effect of VEGF on the regenerative capacity of muscle stem cells in dystrophic skeletal muscle. Molecular Therapy. 2009 Oct;17(10):1788-98. Epub 2009 Jul 14.
- Li G, Corsi-Payne K, Zheng B, Usas A, Peng H, Huard J. The Dose of Growth Factors Influences the Synergistic Effect of Vascular Endothelial Growth Factor on Bone Morphogenetic Protein 4-Induced Ectopic Bone Formation. Tissue Engineering. Part A. 2009 Aug;15(8):2123-33.
- Matsumoto T, Cooper GM, Gharaibeh B, Meszaros LB, Li G, Usas A, Fu FH, Huard J. Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble flt-1. Arthritis and Rheumetism. 2009 May;60(5):1390-405.
- Ambrosio F, Kadi F, Lexell J, Fitzgerald GK, Boninger ML, Huard J. The effect of muscle loading on skeletal muscle regenerative potential: an update of current research findings relating to aging and neuromuscular pathology. American Journal of Physical Medicine and Rehabilitation. 2009 Feb;88(2):145-55. Review.
- Cooper GM, Usas A, Olshanski A, Mooney MP, Losee JE, Huard J. Ex vivo Noggin gene therapy inhibits bone formation in a mouse model of postoperative resynostosis. Plastic and Reconstructive Surgery. 2009 Feb;123(2 Suppl):94S-103S.
- Ambrosio F, Ferrari RJ, Fitzgerald GK, Carvell G, Boninger ML, Huard J. Functional overloading of dystrophic mice enhances muscle-derived stem cell contribution to muscle contractile capacity. Archives of Physical Medicine and Rehabilitation. 2009 Jan;90(1):66-73.
- Kubo S, Cooper GM, Matsumoto T, Phillippi JA, Corsi KA, Usas A, Li G, Fu FH, Huard J. Blocking vascular endothelial growth factor with soluble Flt-1 improves the chondrogenic potential of mouse skeletal muscle-derived stem cells. Arthritis and Rheumetism. 2009 Jan;60(1):155-65.
- Urish KL, Vella JB, Okada M, Deasy BM, Tobita K, Keller BB, Cao B, Piganelli JD, Huard J. Antioxidant levels represent a major determinant in the regenerative capacity of muscle stem cells. Molecular Biology of the Cell. 2009 Jan;20(1):509-20. Epub 2008 Nov 12.
- Usas A, Ho AM, Cooper GM, Olshanski A, Peng H, Huard J. Bone Regeneration Mediated by BMP4-Expressing Muscle-Derived Stem Cells Is Affected by Delivery System. Tissue Engineering. Part A. 2008 Dec 6. [Epub ahead of print]
- Okada M, Payne TR, Zheng B, Oshima H, Momoi N, Tobita K, Keller BB, Phillippi JA, Péault B, Huard J. Myogenic endothelial cells purified from human skeletal muscle improve cardiac function after transplantation into infarcted myocardium. Journal of the American College of Cardiology. 2008 Dec 2;52(23):1869-80.
- Nozaki M, Li Y, Zhu J, Ambrosio F, Uehara K, Fu FH, Huard J. Improved muscle healing after contusion injury by the inhibitory effect of suramin on myostatin, a negative regulator of muscle growth. American Journal of Sports Medicine. 2008 Dec;36(12):2354-62. Epub 2008 Aug 25.
- Matsumoto T, Kubo S, Meszaros LB, Corsi KA, Cooper GM, Li G, Usas A, Osawa A, Fu FH, Huard J. The influence of sex on the chondrogenic potential of muscle-derived stem cells: implications for cartilage regeneration and repair. Arthritis and Rheumetism. 2008 Dec;58(12):3809-19.
- Crisan M, Yap S, Casteilla L, Chen CW, Corselli M, Park TS, Andriolo G, Sun B, Zheng B, Zhang L, Norotte C, Teng PN, Traas J, Schugar R, Deasy BM, Badylak S, Buhring HJ, Giacobino JP, Lazzari L, Huard J, Péault B. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell. 2008 Sep 11;3(3):301-13.
- Kaar JL, Li Y, Blair HC, Asche G, Koepsel RR, Huard J, Russell AJ. Matrix metalloproteinase-1 treatment of muscle fibrosis. Acta Biomaterialia. 2008 Sep;4(5):1411-20. Epub 2008 Apr 7.
- Vadalà G, Sobajima S, Lee JY, Huard J, Denaro V, Kang JD, Gilbertson LG. In vitro interaction between muscle-derived stem cells and nucleus pulposus cells. Spine Journal. 2008 Sep-Oct;8(5):804-9. Epub 2007 Nov 26.
- Bedair HS, Karthikeyan T, Quintero A, Li Y, Huard J. Angiotensin II receptor blockade administered after injury improves muscle regeneration and decreases fibrosis in normal skeletal muscle. American Journal of Sports Medicine. 2008 Aug;36(8):1548-54. Epub 2008 Jun 11. Erratum in: American Journal of Sports Medicine. 2008 Dec;36(12):2465.
- Lu A, Cummins JH, Pollett JB, Cao B, Sun B, Rudnicki MA, Huard J. Isolation of myogenic progenitor populations from Pax7-deficient skeletal muscle based on adhesion characteristics. Gene Therapy. 2008 Aug;15(15):1116-25. Epub 2008 May 29.
CONTACT INFORMATION
Dr. Johnny Huard
Phone: (412) 648-2798
Email: jhuard@pitt.edu
