Patricia A. Hebda, Ph.D.
Selected recent publications:
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Sandulache VC, Singh T, Li-Korotky HS, Lo CY, Otteson TD, Barsic M, Dohar JE, Hebda PA. Prostaglandin E2 is activated by airway injury and regulates fibroblast cytoskeletal dynamics. The Laryngoscope. 2009 Jul;119(7):1365-73.
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Parekh A, Mantle B, Banks J, Swarts JD, Badylak SF, Dohar JE, Hebda PA. Repair of the tympanic membrane with urinary bladder matrix. The Laryngoscope. 2009 Jun;119(6):1206-13.
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Parekh A, Sandulache VC, Singh T, Cetin S, Sacks MS, Dohar JE, Hebda PA. Prostaglandin E2 differentially regulates contraction and structural reorganization of anchored collagen gels by human adult and fetal dermal fibroblasts. Wound Repair and Regeneration. 2009 Jan-Feb;17(1):88-98.
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Yates CC, Whaley D, Hooda S, Hebda PA, Bodnar RJ, Wells A. Delayed reepithelialization and basement membrane regeneration after wounding in mice lacking CXCR3. Wound Repair and Regeneration. 2009 Jan-Feb;17(1):34-41.
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Yates CC, Whaley D, Y-Chen A, Kulesekaran P, Hebda PA, Wells A. ELR-negative CXC chemokine CXCL11 (IP-9/I-TAC) facilitates dermal and epidermal maturation during wound repair. American Journal of Pathology. 2008 Sep;173(3):643-52. Epub 2008 Jul 31.
Li NY, Verdolini K, Clermont G, Mi Q, Rubinstein EN, Hebda PA, Vodovotz Y. A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury. PLoS One. 2008 Jul 30;3(7):e2789.
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Otteson TD, Sandulache VC, Barsic M, Disilvio GM, Hebda PA, Dohar JE. Acute and chronic changes in the subglottis induced by graded carbon dioxide laser injury in the rabbit airway. Archives of Otolaryngology – Head and Neck Surgery. 2008 Jul;134(7):694-702. Erratum in: Archives of Otolaryngology – Head and Neck Surgery. 2008 Oct;134(10):1106.
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Branski RC, Perera P, Verdolini K, Rosen CA, Hebda PA, Agarwal S. Dynamic biomechanical strain inhibits IL-1beta-induced inflammation in vocal fold fibroblasts. Journal of Voice. 2007 Nov;21(6):651-60. Epub 2006 Aug 14.
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Sandulache VC, Parekh A, Dohar JE, Hebda PA. Fetal dermal fibroblasts retain a hyperactive migratory and contractile phenotype under 2-and 3-dimensional constraints compared to normal adult fibroblasts. Tissue Engineering. 2007 Nov;13(11):2791-801.
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Li-Korotky HS, Hebda PA, Lo CY, Dohar JE. Age-dependent differential expression of fibronectin variants in skin and airway mucosal wounds. Archives of Otolaryngology – Head and Neck Surgery. 2007 Sep;133(9):919-24.
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Yates CC, Whaley D, Kulasekeran P, Hancock WW, Lu B, Bodnar R, Newsome J, Hebda PA, Wells A. Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptor. American Journal of Pathology. 2007 Aug;171(2):484-95. Epub 2007 Jun 28.
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Parekh A, Sandulache VC, Lieb AS, Dohar JE, Hebda PA. Differential regulation of free-floating collagen gel contraction by human fetal and adult dermal fibroblasts in response to prostaglandin E2 mediated by an EP2/cAMP-dependent mechanism. Wound Repair and Regeneration. 2007 May-Jun;15(3):390-8.
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Sandulache VC, Chafin JB, Li-Korotky HS, Otteson TD, Dohar JE, Hebda PA. Elucidating the role of interleukin 1beta and prostaglandin E2 in upper airway mucosal wound healing. Archives of Otolaryngology – Head and Neck Surgery. 2007 Apr;133(4):365-74.
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Chafin JB, Sandulache VC, Dunklebarger JL, Otteson TD, Hoffmann PJ, Hebda PA, Dohar JE. Graded carbon dioxide laser-induced subglottic injury in the rabbit model. Archives of Otolaryngology – Head and Neck Surgery. 2007 Apr;133(4):358-64. Erratum in: Archives of Otolaryngology – Head and Neck Surgery. 2007 Jul;133(7):683. Hoffmann, Paul A [corrected to Hoffmann, Paul J].
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Hebda PA, Yuksel S, Dohar JE. Effects of ciprofloxacin-dexamethasone on myringotomy wound healing. The Laryngoscope. 2007 Mar;117(3):522-8.
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Li-Korotky HS, Kelly LA, Piltcher O, Hebda PA, Doyle WJ. Evaluation of microbial RNA extractions from Streptococcus pneumoniae. Journal of Microbiological Methods. 2007 Feb;68(2):342-8. Epub 2006 Nov 13.
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Sandulache VC, Parekh A, Li-Korotky H, Dohar JE, Hebda PA. Prostaglandin E2 inhibition of keloid fibroblast migration, contraction, and transforming growth factor (TGF)-beta1-induced collagen synthesis. Wound Repair and Regeneration. 2007 Jan-Feb;15(1):122-33.
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Krishna P, Rosen CA, Branski RC, Wells A, Hebda PA. Primed fibroblasts and exogenous decorin: potential treatments for subacute vocal fold scar. Otolaryngology – Head and Neck Surgery. 2006 Dec;135(6):937-45.
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Branski RC, Verdolini K, Sandulache V, Rosen CA, Hebda PA. Vocal fold wound healing: a review for clinicians. Journal of Voice. 2006 Sep;20(3):432-42. Epub 2005 Dec 1. Review.
CONTACT INFORMATION
Dr. Patricia Hebda
Phone: (412) 692-6217
Email: patricia.hebda@chp.edu