David J. Hackam, M.D., Ph.D.
Selected recent publications:

  • Cetin S, Leaphart C, Li J, Upperman JS, Grishin A, Qureshi FR, Agarwal C, Ford HR, Hackam DJ. Nitric oxide inhibits enterocyte migration by activating the cytoskeletal protein RHO-GTPase in an SHP-2 dependent manner. Oral Presentation. Society of University Surgeons, February 9-12, 2005, Nashville, TN
  • Leaphart CL, Qureshi F, Cetin S, Sabnis A, Li J, Grishin A, Ford H, Hackam DJ. Interferon-Gamma inhibits enterocyte migration by dephosphoralating the gap junction protein connexin43. Poster Presentation. Society of University Surgeons, February 9-12, 2005, Nashville, TN
  • Grishin AV, Wang J, Hackam D, Upperman J, Zamora R. LPS induces apoptosis in enterocytes. Poster Presentation. Society of University Surgeons, February 9-12, 2005, Nashville,TN
  • Qureshi FG, Leaphart C, Cetin S, Li J, Upperman J, Watkins S, Ford HR, Hackam DJ. Endotoxin inhibits enterocyte migration by incresing integrin expression and function in a P13K dependent manner. 3rd International NEC Symposium. April 15-16, 2005, Columbus, OH
  • Leaphart C, Qureshi F, Cetin S, Sabnis A, Li J, Upperman J, Ford H, Hackam DJ. Interferon-y inhibits enterocyte migration by de-phosphorylating the gap junction protein connexin43. 3rd International NEC Symposium, April 15-16, 2005, Columbus, OH
  • Cetin S, Leaphart C, Li J, Upperman J, Grishin A, Qureshi F, Agarwal C, Ford H, Hackam D. Nitric oxide inhibits enterocyte migration by activating the cytoskeletal protein Rho-GTPase in an SHP-2 dependent manner. 3rd International NEC Symposium, April 15-16, 2005, Columbus, OH
  • Leaphart CL, Qureshi F, Cetin S, Li J, Upperman JS, Ford HR, Zamora R, Hackam, DJ. Nitric oxide is a negative regulator of gap junction communication between enterocytes during intestinal inflammation. Poster Presentation. Surgical Infection Society, April 29-May 2, 2004, Miami, FL
  • Grishin AV, Wang J, Hackam DJ, Zamora R, Upperman J, Ford HR. A novel P38 pathway mediates response to endotoxin in enterocytes. Poster Presentation. Surgical Infection Society, April 29-May 2, 2004, Miami, FL
  • Leaphart C, Qureshi FG, Cetin S, Sabnis A, Li J, Upperman J, Ford H, Hackam DJ. Interferon-γ inhibits enterocyte migration by de-phosphorylating the gap junction protein connexin-43. Oral and Poster Presentation. Local Traffic 2005, May 20, 2005
  • Cetin S, Leaphart C, Li J, Ford HR, Hackam DJ. Nitric oxide impairs enterocyte migration through inactivation of the small GTP protein RAC1. Poster Presentation. American Pediatric Surgical Association, May 29- June 1, 2005, Phoenix, AZ
  • Leaphart C, Rivenberg M, Neal M, Cetin S, Li J. Ford HR, Hackam DJ. The role of toll like receptor 4 in the pathogenesis of necrotizing enterocolitis. Poster Presentation. American Pediatric Surgical Association, May 29 – June 1, 2005, Phoenix, AZ
  • Leaphart C, Cetin S, Ford H, Guo F, Upperman J, Stolz D, Lotze M, Tracey K, Yang H, Li J, Hackam D. HMGB1 disrupts enterocyte barrier integrity by impairing enterocyte communication and inhibiting phosphorylation of connexin-43. Poster Presentation. 28th Annual Conference on Shock, Marco Island, FL, June 4-7, 2005
  • Cetin S, Leaphart C, Ford H, Upperman J, Lotze M, Zamora R, Tracey K, Yang H, Li J, Hackam D. HMGB1 impairs enterocyte migration by disrupting the actin cytoskeleton and inhibiting RHO-GTPase. Poster Presentation. 28th Annual Conference on Shock, Marco Island, FL, June 4-7, 2005
  • Leaphart CL, Hackam DJ. Interferon gamma displaces connexin-43 from lipid rafts in a phorbol-ester dependent manner resulting in impaired enterocyte communication and migration. Oral Presentation. 91st Annual Clinical Congress of the American College of Surgeons, San Francisco, CA, October 16-20, 2005
  • Leaphart CL, Hackam DJ. Epidermal growth factor (EGF) enchances intestinal restitution by increasing gap junction communication between adjacent enterocytes. Oral Presentation. American Academy of Pediatrics 2005 national Conference & Exhibition, Washington, DC, October 8-12, 2005

CONTACT INFORMATION

David J. Hackam, M.D., Ph.D.
Phone: (412) 692-8735
Email: david.hackam@chp.edu