Dr. Joseph Glorioso is a Professor and Chairman of the Department of Molecular Genetics & Biochemistry at the University of Pittsburgh. However, in addition to his responsibilities within the School of Medicine, he is also an active research investigator. Recently, he has been featured in several publications for his work surrounding the herpes simplex virus (HSV). More specifically, Dr. Glorioso is currently researching the natural history of the virus, which involves repeated cycles of recurrent infection initiated by endogenous latent virus residing in the peripheral nervous system.
Broadly, the overall aims of Dr. Glorioso and his research team are:
- To achieve a greater understanding of the genetic basis of latency and neurovirulence
- To precisely define viral envelope glycoprotein-receptor interactions that occur during virus attachment and entry and devise strategies for retargeting virus infection through recognition of novel receptors
- To develop HSV as a gene transfer vector suitable for treatment of nervous system diseases such as cancer (e.g. glioblasoma), neurodegenerative conditions (e.g. diabetic neuropathy), auto-immune brain disease (e.g. multiple sclerosis) and a variety of types of pain.
Joseph C. Glorioso III, Ph.D.
Phone: (412) 648 - 8105