Selected recent publications:
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Ma J, Defrances MC, Zou C, Johnson C, Ferrell R, Zarnegar R. Somatic mutation and functional polymorphism of a novel regulatory element in the HGF gene promoter causes its aberrant expression in human breast cancer. Journal of Clinical Investigation.2009 Feb 2. pii: 36640. doi: 10.1172/JCI36640.
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Han C, Li G, Lim K, DeFrances MC, Gandhi CR, Wu T. Transgenic expression of cyclooxygenase-2 in hepatocytes accelerates endotoxin-induced acute liver failure.
Journal of Immunology. 2008 Dec 1;181(11):8027-35. -
He X, Zhu Z, Johnson C, Stoops J, Eaker AE, Bowen W, DeFrances MC. PIK3IP1, a negative regulator of PI3K, suppresses the development of hepatocellular carcinoma. Cancer Research. 2008 Jul 15;68(14):5591-8.
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Zou C, Ma J, Wang X, Guo L, Zhu Z, Stoops J, Eaker AE, Johnson CJ, Strom S, Michalopoulos GK, DeFrances MC, Zarnegar R. Lack of Fas antagonism by Met in human fatty liver disease. Nature Medicine. 2007 Sep;13(9):1078-85. Epub 2007 Aug 19.
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Zhu Z, He X, Johnson C, Stoops J, Eaker AE, Stoffer DS, Bell A, Zarnegar R, DeFrances MC. PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein. Biochemical and Biophysical Research Communications. 2007 Jun 22;358(1):66-72. Epub 2007 Apr 24.
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Wang X, DeFrances MC, Dai Y, Pediaditakis P, Johnson C, Bell A, Michalopoulos GK, Zarnegar R. A mechanism of cell survival: sequestration of Fas by the HGF receptor Met. Molecular Cell. 2002 Feb;9(2):411-21.
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Jiang JG, DeFrances MC, Machen J, Johnson C, Zarnegar R. The repressive function of AP2 transcription factor on the hepatocyte growth factor gene promoter. Biochemical and Biophysical Research Communications. 2000 Jun 16;272(3):882-6.
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Bell A, Chen Q, DeFrances MC, Michalopoulos GK, Zarnegar R. The five amino acid-deleted isoform of hepatocyte growth factor promotes carcinogenesis in transgenic mice. Oncogene. 1999 Jan 28;18(4):887-95.
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Michalopoulos GK, DeFrances MC. Liver regeneration. Science. 1997 Apr 4;276(5309):60-6. Review.
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Chen Q, DeFrances MC, Zarnegar R. Induction of met proto-oncogene (hepatocyte growth factor receptor) expression during human monocyte-macrophage differentiation. Cell Growth and Differation. 1996 Jun;7(6):821-32.
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Krasnoselsky A, Massay MJ, DeFrances MC, Michalopoulos G, Zarnegar R, Ratner N. Hepatocyte growth factor is a mitogen for Schwann cells and is present in neurofibromas. Journal of Neuroscience. 1994 Dec;14(12):7284-90.
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Weir E, Chen Q, DeFrances MC, Bell A, Taub R, Zarnegar R. Rapid induction of mRNAs for liver regeneration factor and insulin-like growth factor binding protein-1 in primary cultures of rat hepatocytes by hepatocyte growth factor and epidermal growth factor. Hepatology. 1994 Oct;20(4 Pt 1):955-60.
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View Dr. DeFrances' publications on PubMed
Contact Information:
Marie C. DeFrances, M.D., Ph.D.Phone: (412) 648-8346
Email: defrancesmc@upmc.edu
Website: http://path.upmc.edu/personnel/Faculty/DeFrances.htm