Marie C. DeFrances, MD, PhD

Dr. Marie DeFrances is an Associate Professor in the Department of Pathology, Division of Molecular Diagnostics, and the Associate Director of the Clinical Pathology Residency Training Program and the Director of the Molecular and Genomic Pathology Fellowship Training Program, both in the Department of Pathology. Dr. DeFrances earned her Bachelor of Science in Zoology at Duke University. She then studied at the University of Pittsburgh, where she earned first her doctorate in Pathology and then her MD, which she achieved cum laude.

In her research, Dr. DeFrances focuses on the

  • characterization of a novel regulator of the PI3K pathway;
  • pathobiology of liver cancer in humans and rodents; and
  • biology of liver regeneration in humans and rodents.

Dr. DeFrances' clinical responsibilities are in the Molecular Diagnostics Laboratory in the Division of Molecular and Genomic Pathology where she is involved with day-to-day review of patient material and test development. Dr. DeFrances also is Director of the MS1 course, “Cellular and Pathologic Basis of Disease Course,” and Co-Director of the graduate courses, “Basics of Personalized Medicine” and “Pathology Research Seminar.”

Dr. DeFrances is a member of several professional associations, such as the Alpha Omega Alpha Medical Honor Society, the American Association for the Study of Liver Diseases, and the Association for Molecular Pathology. She serves as a referee for several journals, including Oncogene, Molecular Carcinogenesis, Cancer Research, Journal of Hepatology, Gastroenterology, and Metabolism. She is a Member of the Association of Pathology Chairs, Medical Student Education Committee. She is also a multiple recipient of the Pitt Innovator Award.

View a list of Dr. DeFrances’ publications here.

Contact Information:

Dr. Marie C. DeFrances
Phone: (412) 648-8346