Marie C. DeFrances, M.D., Ph.D.

Dr. Marie DeFrances is an Associate Professor of Pathology and the Assistant Director in the Division of Molecular Diagnostics at the University of Pittsburgh. Dr. DeFrances earned her Bachelor of Science in Zoology at Duke University. She then studied at the University of Pittsburgh, where she earned first her doctorate in Pathology and then her Medical Degree, which she achieved cum laude.

In her research, Dr. DeFrances focuses on characterization of a novel regulator of the PI3K pathway.  She explores regulation at the molecular level using in vivo and in vitro models as well as unraveling the role of PI3K signaling in normal and neoplastic human and rodent liver.  Also studied is the pathobiology of liver cancer and the biology of liver regeneration in humans and rodents.

Dr. DeFrances is a member of several professional associations, such as the Alpha Omega Alpha Medical Honor Society, the American Association for the Study of Liver Diseases, and the Association for Molecular Pathology.  She serves as a referee for several journals, including Oncogene and Molecular Carcinogenesis.  She is a Career Advisor in the Physician Scientist Training Program at the University of Pittsburgh and a Committee Member of the Women’s Task Force, Department of Pathology.  She is also a multiple recipient of the Pitt Innovator Award.

View Publications

Contact Information:

Marie C. DeFrances, M.D., Ph.D.
Phone: (412) 648-8346