Selected recent publications:

• Xiang G, Yang Q, Wang B, Sekiya N, Mu X, Tang Y, Chen C-, Okada M, Cummins J, Gharaibeh B, Huard J. Lentivirus-mediated wnt11 gene transfer enhances cardiomyogenic differentiation of skeletal muscle-derived stem cells. Molecular Therapy [Internet]. 2011;19(4):790-6.
• Tang Y, Cummins J, Huard J, Wang B. AAV-directed muscular dystrophy gene therapy. Expert Opinion on Biological Therapy [Internet]. 2010;10(3):395-408.
• Gharaibeh B, Lu A, Tebbets J, Zheng B, Feduska J, Crisan M, Péault B, Cummins J, Huard J. Isolation of a slowly adhering cell fraction containing stem cells from murine skeletal muscle by the preplate technique. Nature Protocols [Internet]. 2008;3(9):1501-9.
• Kuroda R, Usas A, Kubo S, Corsi K, Peng H, Rose T, Cummins J, Fu FH, Huard J. Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells. Arthritis Rheum [Internet]. 2006;54(2):433-42.
• Lavasani M, Lu A, Peng H, Cummins J, Huard J. Nerve growth factor improves the muscle regeneration capacity of muscle stem cells in dystrophic muscle. Hum Gene Ther [Internet]. 2006;17(2):180-92.
• Oshima H, Payne TR, Urish KL, Sakai T, Ling Y, Gharaibeh B, Tobita K, Keller BB, Cummins JH, Huard J. Differential myocardial infarct repair with muscle stem cells compared to myoblasts. Molecular Therapy [Internet]. 2005;12(6):1130-41.
• Shen W, Li Y, Tang Y, Cummins J, Huard J. NS-398, a cyclooxygenase-2-specific inhibitor, delays skeletal muscle healing by decreasing regeneration and promoting fibrosis. Am J Pathol [Internet]. 2005;167(4):1105-17.
• Payne TR, Oshima H, Sakai T, Ling Y, Gharaibeh B, Cummins J, Huard J. Regeneration of dystrophin-expressing myocytes in the mdx heart by skeletal muscle stem cells. Gene Ther [Internet]. 2005;12(16):1264-74.
• Shen H-, Peng H, Usas A, Gearhart B, Cummins J, Fu FH, Huard J. Ex vivo gene therapy-induced endochondral bone formation: Comparison of muscle-derived stem cells and different subpopulations of primary muscle-derived cells. Bone [Internet]. 2004;34(6):982-92.
• Li Y, Foster W, Deasy BM, Chan Y, Prisk V, Tang Y, Cummins J, Huard J. Transforming growth factor-β1 induces the differentiation of myogenic cells into fibrotic cells in injured skeletal muscle: A key event in muscle fibrogenesis. Am J Pathol [Internet]. 2004;164(3):1007-19.
• Kimura S, Ikezawa M, Cao B, Kanda Y, Pruchnic R, Cummins J, Huard J, Miike T, Suzuki S. Ex vivo gene transfer to mature skeletal muscle by using adenovirus helper cells. J Gene Med [Internet]. 2004;6(2):155-65.
• Cao B, Zheng B, Jankowski RJ, Kimura S, Ikezawa M, Deasy B, Cummins J, Epperly M, Qu-Petersen Z, Huard J. Muscle stem cells differentiate into haematopoietic lineages but retain myogenic potential. Nat Cell Biol [Internet]. 2003;5(7):640-6.
• Pelinkovic D, Lee J-, Engelhardt M, Rodosky M, Cummins J, Fu FH, Huard J. Muscle cell-mediated gene delivery to the rotator cuff. Tissue Eng [Internet]. 2003;9(1):143-51.
• Peng H, Wright V, Usas A, Gearhart B, Shen H-, Cummins J, Huard J. Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4. J Clin Invest [Internet]. 2002;110(6):751-9.
• Lee JY, Huard J, Peng H, Usas A, Musgrave D, Cummins J, Pelinkovic D, Jankowski R, Ziran B, Robbins P. Enhancement of bone healing based on ex vivo gene therapy using human muscle-derived cells expressing bone morphogenetic protein 2. Hum Gene Ther [Internet]. 2002;13(10):1201-11.

CONTACT INFORMATION

James H. Cummins
Phone: (412) 692-5967
Email: James.Cummins@chp.edu