Selected recent publications:

• CT Chu (2011) Diversity in the regulation of autophagy & mitophagy: Lessons from Parkinson's disease. Parkinson's Disease, Vol 2011, Article ID 789431, 8 pages. doi:10.4061/2011/789431 (review)
• S Van Laar, BA Arnold, SJ Cassady, CT Chu, EA Burton & SB Berman. (2011) Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization. Hum Mol Genet 20: 927-940.
• Cherra SJ 3rd, Kulich SM, Uechi G, Balasubramani M, Mountzouris J, Day BW, Chu CT.  Regulation of the autophagy protein LC3 by phosphorylation.  Journal of Cell Biology.  2010 Aug 23;190(4):533-9.  Epub 2010 Aug 16.


• Zhu J, Chu CT.  Mitochondrial dysfunction in Parkinson's disease.  Journal of Alzheimers Disease.  2010;20 Suppl 2:S325-34.  Review.
• Bear DM, Williams A, Chu CT, Coyle CH, Chu CR.  Optical coherence tomography grading correlates with MRI T2 mapping and extracellular matrix content.  Journal of Orthopaedic Research.  2010 Apr;28(4):546-52.
• Dagda RK, Cherra SJ 3rd, Kulich SM, Tandon A, Park D, Chu CT.  Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission.  Journal of Biological Chemistry. 2009 May 15;284(20):13843-55. Epub 2009 Mar 10.
• Dagda RK, Zhu J, Kulich SM, Chu CT.  Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease.  Autophagy.  2008 Aug 16;4(6):770-82.  Epub 2008 Jun 16.
• Chu CT. Eaten alive: autophagy and neuronal cell death after hypoxia-ischemia.Am J Pathol. 2008 Feb;172(2):284-7. Epub 2008 Jan 17. Review. No abstract available. Erratum in: Am J Pathol. 2008 Apr;172(4):1153.
• Plowey ED, Cherra SJ 3rd, Liu YJ, Chu CT. Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. J Neurochem. 2008 May;105(3):1048-56.
• Clark RS, Bayir H, Chu CT, Alber SM, Kochanek PM, Watkins SC. Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness. Autophagy. 2008 Jan-Feb;4(1):88-90.
• Chu CT, Plowey ED, Wang Y, Patel V, Jordan-Sciutto KL. Location, location, location: altered transcription factor trafficking in neurodegeneration. J Neuropathol Exp Neurol. 2007 Oct;66(10):873-83. Review.
• Lai Y, Hickey RW, Chen Y, Bayir H, Sullivan ML, Chu CT, Kochanek PM, Dixon CE, Jenkins LW, Graham SH, Watkins SC, Clark RS. Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester. J Cereb Blood Flow Metab. 2008 Mar;28(3):540-50.
• Chu CT, Zhu J, Dagda R. Beclin 1-independent pathway of damage-induced mitophagy and autophagic stress: implications for neurodegeneration and cell death. Autophagy. 2007 Nov-Dec;3(6):663-6.
• Lai Y, Hickey RW, Chen Y, Bayir H, Sullivan ML, Chu CT, Kochanek PM, Dixon CE, Jenkins LW, Graham SH, Watkins SC, Clark RS. Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester. J Cereb Blood Flow Metab. 2008 Mar;28(3):540-50.
• Kulich SM, Horbinski C, Patel M, Chu CT. 6-Hydroxydopamine induces mitochondrial ERK activation. Free Radic Biol Med. 2007 Aug 1;43(3):372-83.
• Kiselyov K, Jennigs JJ Jr, Rbaibi Y, Chu CT. Autophagy, mitochondria and cell death in lysosomal storage diseases. Autophagy. 2007 May-Jun;3(3):259-62. Epub 2007 May 23.


• Ramsey CP, Glass CA, Montgomery MB, Lindl KA, Ritson GP, Chia LA, Hamilton RL, Chu CT, Jordan-Sciutto KL. Expression of Nrf2 in neurodegenerative diseases. J Neuropathol Exp Neurol. 2007 Jan;66(1):75-85.
• Zhu JH, Horbinski C, Guo F, Watkins S, Uchiyama Y, Chu CT. Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am J Pathol. 2007 Jan;170(1):75-86.
• Jennings JJ Jr, Zhu JH, Rbaibi Y, Luo X, Chu CT, Kiselyov K. Mitochondrial aberrations in mucolipidosis Type IV. J Biol Chem. 2006 Dec 22;281(51):39041-50.

CONTACT INFORMATION

Dr. Charleen T. Chu
Phone: 412-383-5379
Email: ctc4@pitt.edu