Augustine M.K. Choi, M.D.
Selected recent publications:

  • Ameredes BT, Sethi JM, Liu HL, Choi AMK, Calhoun WJ. Enhanced nitric oxide production associated with airway hyporesponsiveness in the absence of IL-10. Am J Physiol Lung Cell Mol Physiol. 288(5):L868-73, 2005.

  • Zhou Z, Song R, Fattman CL, Greenhill S, Alber S, Oury TD, Choi AMK, Morse D. Carbon monoxide suppresses bleomycin-induced lung fibrosis. Am J Pathol. 166:27-37, 2005.

  • Nakao A, Neto JS, Kanno S, Stolz DB, Kimizuka K, Liu F, Bach FH, Billiar TR, Choi AMK, Otterbein LE, Murase N. Protection against ischemia/reperfusion injury in cardiac and renal transplantation with carbon monoxide, biliverdin and both. Am J Transplant. 5:282-91, 2005.

  • Wang X, Wang Y, Zhang J, Kim HP, Ryter SW, Choi AMK. FLIP protects against hypoxia/reoxygenation-induced endothelial cell apoptosis by inhibiting Bax activation. Mol Cell Biol. 25:4742-51, 2005.

  • Sarady-Andrews J, Liu F, Gallo D, Nakao A, Overhaus M, Ollinger R, Choi AMK, Otterbein LE. Biliverdin administration protects against endotoxin-induced acute lung injury in rats. Am J Physiol Lung Cell Mol Physiol. 289(6):L1131-7, 2005.

  • Ning W, Choi AMK, Li C. Carbon monoxide inhibits IL-17-induced IL-6 production through the MAPK pathway in human pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol. 289(2):L268-73, 2005.

  • Ameredes BT, Zamora R, Sethi JM, Liu HL, Kohut LK, Gligonic AL, Choi AMK, Calhoun WJ. Alterations in nitric oxide and cytokine production with airway inflammation in the absence of IL-10. J Immunol. 175(2): 1206-13, 2005.

  • Jin Y, Kim HP, Ifedigbo E, Lau LF, Choi AMK. Cyr61 protects against hyperoxia-induced cell death via Akt pathway in pulmonary epithelial cells. Am J Respir Cell Mol Biol. 33(3):297-302, 2005.

  • Moore BA, Overhaus M, Whitcomb J, Ifedigbo E, Choi AMK, Otterbein LE, Bauer AJ. Brief inhalation of low-dose carbon monoxide protects rodents and swine from postoperative ileus. Crit Care Med. 33(6):1317-26, 2005.

  • Morse D, Choi AMK. Heme oxygenase-1: from bench to bedside. Am J Respir Crit Care Med. 172(6):660-70, 2005.

  • Kim HP, Wang X, Zhang J, Suh GY, Benjamin IJ, Ryter SW, Choi AMK. Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38beta MAPK and heat shock factor-1. J Immunol. 175(4):2662-9, 2005.

  • Kim HP, Wang X, Nakao A, Kim SI, Murase N, Choi ME, Ryter SW, Choi AMK. Caveolin-1 expression by means of p38beta mitogen-activated protein kinase mediates the antiproliferative effect of carbon monoxide. Proc Natl Acad Sci USA. 02(32):11319-24, 2005.

  • Jin Y, Choi AMK. Cytoprotection of heme oxygenase-1/carbon monoxide in lung injury. Proc Am Thorac Soc. 2(3):232-5, 2005.

  • Ryter SW, Choi AMK. Heme oxygenase-1: redox regulation of a stress protein in lung and cell culture models. Antioxid Redox Signal. 7(1-2):80-91, 2005.

  • Choi AMK, Dolinay T. “Therapeutic” carbon monoxide may be a reality soon. Am J Respir Crit Care Med. Jun 1:171(6):613-20, 2005.

  • Pischke SE, Zhou Z, Song R, Ning W, Alam J, Ryter SW, Choi AMK. Phosphatidylinositol 3-kinase/akt pathway mediates heme oxygenase-1 regulation by lipopolysaccharide. Cell Mol Biol. Oct 3:51(5):461-70, 2005.

  • Ryter S, Alam J, and Choi AMK. Heme oxygenase-1/carbon monoxide. From basic science to therapeutic applications. Physiological Reviews. 86(2):583-650, 2006.

  • Wang XM, Kim HP, Song R, Choi AMK. Caveolin-1 confers anti-inflammatory effects in murine macrophages via the MKK3/p38 MAPK pathway. Am J Respir Cell Mol Biol. 34(4):434-42, 2006.

  • Kim HP, Ryter SW, Choi AMK. CO as a cellular signaling molecule. Ann Rev Pharmacol Toxicol. 46:411-49, 2006.

  • Ryter SW, Choi AMK. Therapeutic applications of carbon monoxide in lung disease. Curr Opin Pharmacol. 6(3):257-62, 2006.

  • Nakao A, Toyokawa H, Abe M, Kiyomoto T, Nakahira K, Choi AMK, Nalesnik M, Thomson A, Murasse N. Heart allograft protection with low-dose carbon monoxide inhalation: effects on inflammatory mediators and alloreactive T-cell responses. Transplantation. 81(2):220-230, 2006.

  • Suh GY, Jin Y, Yi AK, Wang XM, Choi AMK. CCAAT/enhancer-binding Protein Mediates Carbon Monoxide-induced Suppression of Cyclooxygenase-2. Am J Respir Cell Mol Biol. Aug;35(2):220-6, 2006.

  • Dolinay T, Kaminski N, Felgendreher M, Kim HP, Reynolds P, Watkins SC, Karp D, Uhlig S, Choi AMK. Gene expression profiling of target genes in ventilator-induced lung injury. Physiol Genomics. 26(1):68-75, 2006.

  • Peters DG, Ning W, Chu TJ, Li CJ, Choi AMK. Comparative SAGE Analysis of the Response to Hypoxia in Human Pulmonary and Aortic Endothelial Cells. Physiol Genomics. 26(2):99-108, 2006.

  • Neto JS, Nakao A, Toyokawa H, Nalesnik MA, Romanosky AJ, Kimizuka K, Kaizu T, Hashimoto N, Azhipa O, Stolz DB, Choi AMK, Murase N. Low dose carbon monoxide inhalation prevents development of chronic allograft nephropathy. Am J Physiol Renal Physiol. 290(2):F324-34, 2006.

  • Yasuoka H, Jukic DM, Zhou Z, Choi AMK, Feghali-Bostwick CA. Insulin-like growth factor binding protein 5 induces skin fibrosis: A novel murine model for dermal fibrosis. Arthritis Rheum. Sep;54(9):3001-10. 2006.

  • Kohmoto J, Nakao A, Kaizu T, Tsung A, Ikeda A, Tomiyama K, Billiar TR, Choi AMK, Murase N, McCurry KR. Low-dose carbon monoxide inhalation prevents ischemia/reperfusion injury of transplanted rat lung grafts. Surgery. Aug:140(2):179-85, 2006.

  • Nakao A, Toyokawa H, Tsung A, Nalesnik MA, Stolz DB, Kohmoto J, Ikeda A, Tomiyama K, Harada T, Takahashi T, Yang R, Fink MP, Morita K, Choi AMK, Murase N. Ex vivo application of carbon monoxide in University of Wisconsin solution to prevent intestinal cold ischemia/reperfusion injury. Am J Transplant. Oct:6(10):2243-55, 2006.

  • Yasuoka H, Zhou Z, Pilewski JM, Oury TD, Choi AMK, Feghali-Bostwick CA. Insulin-like growth factor-binding protein-5 induces pulmonary fibrosis and triggers mononuclear cellular infiltration. Am J Pathol. Nov; 169(5):1633-42., 2006.

  • Slebos DJ, Ryter SW, van der Toorn M, Liu F, Guo F, Baty CJ, Karlsson JM, Watkins SC, Kim HP, Wang X, Lee JS, Postma DS, Kauffman HF, Choi AMK. Mitochondrial Localization and Function of Heme Oxygenase-1 in Cigarette Smoke-Induced Cell Death. Am J Respir Cell Mol Biol. 2006 Epub Nov 1.

  • Ning W, Dong Y, Sun J, Li C, Mathay MA, Feghali-Bostwick C, Choi AMK. Cigarette smoke stimulates MMP-2 activity via Egr-1 in human lung fibroblasts. Am J Respir Cell Mol Biol. 2006. EPub Nov 10.

  • Ryter SW, Morse D, Choi AMK. Carbon Monoxide and Bilirubin: Potential Therapies for Pulmonary/Vascular Injury and Disease. Am J Respir Cell Mol Biol. 2006 E Pub Sep 15.

  • Nakahira K, Kim HP, Geng XH, Nakao A, Wang X, Jurase N, Drain PF, Wang X, Sasidhar M, Nabel EG, Takahashi T, Lukacs NW, Ryter SW, Morita K, Choi AMK. Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts. J Exp Med. Oct 2:203(10):2377-89, 2006.

  • Wang X, Zhang Y, Kim HP, Zhou Z, Feghali-Bostwick C, Liu F, Ifedigboe E, Xu X, Oury TD, Kaminski N, Choi AMK. Caveolin-1: A critical regulator of lung fibrosis in idiopathic lung fibrosis. J Exp Med. 203(13):2895-906.2006.

  • Wang X, Wang, Y, Kim HP, Nakahira K, Ryter S, Choi AMK. Carbon monoxide protects against hyperoxia-induced endothelial cell apoptosis by inhibiting reactive oxygen species formation. J Biol. Chem. 2006 Epub Nov 29.

CONTACT INFORMATION

Dr. Augustine Choi
Phone: (412) 692-2117
Email: choiam@upmc.edu