Selected Recent Publications:

• Yu H, Shen H, Xiaochun Ping, Feng Xu, Xiaoxia Hu, Yanxin Li, Yun Ling, Jian Yu, Lin Zhang, Sean P. Garrison, Gerard P Zambetti and Cheng T.  Inactivation of PUMA protects stem cells and confers long term survival in response to high dose r-irradiation. Blood 2010 Apr 29;115(17):3472-80. Epub 2010 Feb.
• Yifang Song, Alfred Bahnson, Nathan Hall, Lei Qian, Sallie Boggs, Charalambos Athanassiou, Hui Yu, Hongmei Shen, Doug Koebler, Julie Goff, Raymond Houck and Tao Cheng.  Stem cell traits in long term co-culture revealed by time-lapsed imaging.  Leukemia2010 Jan;24(1):153-61. Epub 2009 Oct 1.
• Xu F, Wang Q and Cheng T.  ADAR1 is required for survival of hematopoietic progenitors but not primitive stem cells via RNA editing.  Proc Natl Acad Sci USA 2009 Oct 20; 106(42): 17763-17768.
• Hu X, Shen H, Tian C, Yu H, Zheng G, Xu F, Ju Z, Xu J, Wang J and Cheng T.  Kinetics of normal hematopoietic stem and progenitor cells in a Notch1-indeuced leukemia model.  Blood 2009 Oct 29; 114(18):3783-92.
• Sung L, Gao S, Shen H, Yu H, Song Y, Smith S, Chang C, Inoue, Kuo L, Lian J, Li A, Tian X, Tuck D, Weissman S, Yang X, and Cheng T.  Differentiated cells are more efficient than adult stem cells as donors for cloning by somatic cell nuclear transfer.  Nature Genetics 2006 Nov;38(11):1323-8. Epub 2006 Oct 1.
• Yuan Y, Yu H, Boyer M, Shen H, Cao S and Cheng T.  Hematopoietic stem cells are not the direct target of spontaneous leukemic transformation in p18INK4C-null reconstituted mice.  Cancer Research 2006 Jan;24(1):48-52.
• Yu H, Yuan Y, Shen H, and Cheng T.   Hematopoietic stem cell exhaustion impacted by p18 and p21 in opposite manners.  Blood 2006; 107(3):1200-6 [2005 Oct 18 Epub ahead of print].
• Yuan Y, Shen H, Franklin DS, Scadden DT and Cheng T.  Self-renewing divisions of hematopoietic stem cells in vivo are increased in the absence of the early G1-phase inhibitor, p18INK4c.  Nature Cell Biology2004; 6(5): 436-42.

CONTACT INFORMATION

Dr. Tao Cheng
5117 Center Ave., Room L211, Pittsburgh, PA 15213
Phone: (412) 623-3249
Fax: (412) 623-7778
Email: chengt@upmc.edu