Alex F. Chen, MD, PhD

Selected recent publications:

  • Li HH, Xu J, Wasserloos KJ, Li J, Tyurina YY, Kagan VE, Wang X, Chen AF, Liu ZQ, Stoyanovsky D, Pitt BR, Zhang LM.  Cytoprotective effects of albumin, nitrosated or reduced, in cultured rat pulmonary vascular cells.  American Journal of Physiology. Lung Cellular and Molecular Physiology.  2011 Apr;300(4):L526-33.  Epub 2011 Jan 14.
  • Li S, Zhu J, Zhang K, Zhang W, Ma X, Popescu LM, Rong R, Zhang M, Xiao C, Chen AF, Yang X, Cai J.  Signature microRNA expression profile of essential hypertension and its novel link to human cytomegalovirus infection. Circulation.  2011 Jul 12;124(2):175-84.  Epub 2011 Jun 20.
  • Wang JM, Luo JD, Chen AF. Sonic hedgehog accelerates wound healing via enhancing cutaneous nitric oxide function in diabetes. Advances in Wound Care. Volume 2.   2011:171-176.
  • Wang XR, Zhang MW, Chen DD, Zhang Y, Chen AF.  AMP-activated protein kinase rescues the angiogenic functions of endothelial progenitor cells via manganese superoxide dismutase induction in type 1 diabetes.  American Journal of Physiology. Endocrinology and Metabolism.  2011 Jun;300(6):E1135-45.  Epub 2011 Mar 22.
  • Jessup JA, Zhang L, Presley TD, Kim-Shapiro DB, Wang H, Chen AF, Groban L.  Tetrahydrobiopterin restores diastolic function and attenuates superoxide production in ovariectomized mRen2.Lewis rats.  Endocrinology.  2011 Jun;152(6):2428-36.  Epub 2011 Mar 22.
  • Xie HH, Zhou S, Chen DD, Channon KM, Su DF, Chen AF.  GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension.  Hypertension.  2010 Dec;56(6):1137-44.  Epub 2010 Nov 8.
  • Zhao T, Li J, Chen AF.  MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1.  American Journal of Physiology. Endocrinology and Metabolism.  2010 Jul;299(1):E110-6.  Epub 2010 Apr 27.
  • He L, Zeng H, Li F, Feng J, Liu S, Liu J, Yu J, Mao J, Hong T, Chen AF, Wang X, Wang G.  Homocysteine impairs coronary artery endothelial function by inhibiting tetrahydrobiopterin in patients with hyperhomocysteinemia.  American Journal of Physiology. Endocrinology and Metabolism.  2010 Dec;299(6):E1061-5.  Epub 2010 Sep 21.
  • Tie L, Li X, Wang X, Channon KM, Chen AF.  Endothelial-specific tetrahydrobiopterin expression accelerates refractory wound healing by suppressing oxidative stress in diabetes. American Journal of Physiology. Endocrinology and Metabolism.  2009 Apr;296:E1423-E1429.
  • Luo JD, Hu TP, Wang L, Chen MS, Liu SM, Chen AF.  Sonic hedgehog improves delayed wound healing via enhancing cutaneous nitric oxide function in diabetes.  American Journal of Physiology. Endocrinology and Metabolism.  2009 Aug;297(2):E525-31.  Epub 2009 Jun 16.
  • Ceylan-Isik AF, Guo KK, Carlson EC, Privratsky JR, Liao SJ, Cai L, Chen AF, Ren J.  Metallothionein abrogates GTP cyclohydrolase I inhibition-induced cardiac contractile and morphological defects: role of mitochondrial biogenesis.  Hypertension.  2009 Jun;53(6):1023-31.  Epub 2009 Apr 27.
  • Liu C, Shen FM, Le YY, Kong Y, Liu X, Cai GJ, Chen AF, Su DF.  Antishock effect of anisodamine involves a novel pathway for activating alpha7 nicotinic acetylcholine receptor.  Critical Care Medicine.  2009 Feb;37(2):634-41.
  • Yang XQ, Chen AF.  High-cholesterol Diet Augments Endothelial Dysfunction via Elevated Oxidative Stress and Reduced BH(4) in Ins2(Akita) Mice, an Autosomal Dominant Mutant Type 1 Diabetic Model.  Clinical and Experimental Pharmacology and Physiology.  2009 Jan 17.
  • Du YH, Chen AF.  A new role for caveolin-1: regulation of guanosine triphosphate cyclohydrolase I and tetrahydrobiopterin in endothelial cells.  Hypertension.  2009 Feb;53(2):115-7.  Epub 2008 Dec 22.
  • Lin HW, Liu CZ, Cao D, Chen PY, Chen MF, Lin SZ, Mozayan M, Chen AF, Premkumar LS, Torry DS, Lee TJ.  Endogenous methyl palmitate modulates nicotinic receptor-mediated transmission in the superior cervical ganglion.  Proceedings of the National Academy of the Sciences of the U S A.  2008 Dec 9;105(49):19526-31.  Epub 2008 Dec 4.  Erratum in: Proceedings of the National Academy of the Sciences of the U S A.  2009 Mar 10;106(10):4060.
  • Yang XQ, Wang YY, Chen AF.  Increased superoxide contributes to enhancement of vascular contraction in Ins2(Akita) diabetic mice, an autosomal dominant mutant model.  Clinical and Experimental Pharmacology and Physiology.  2008 Sep;35(9):1097-103.
  • Tie L, Li XJ, Wang X, Channon KM, Chen AF.  Endothelium-specific GTP cyclohydrolase I overexpression accelerates refractory wound healing by suppressing oxidative stress in diabetes.  American Journal of Physiology.  Endocrinology and Metabolism.  2009 Jun;296(6):E1423-9.  Epub 2009 Mar 31.
  • Chen AF.  Blood pressure variability reduction and organ protection in hypertension treatment.  Hypertension Research.  2008 Apr;31(4):587-8.  Review.
  • Liao SJ, Lin L, Zeng JS, Huang RX, Channon KM, Chen AF.  Endothelium-targeted transgenic GTP-cyclohydrolase I overexpression inhibits neointima formation in mouse carotid artery.  Clinical and Experimental Pharmacology and Physiology.  2007 Dec;34(12):1260-6.
  • Rajanikant GK, Zemke D, Senut MC, Frenkel MB, Chen AF, Gupta R, Majid A.  Carnosine is neuroprotective against permanent focal cerebral ischemia in mice.  Stroke.  2007 Nov;38(11):3023-31.  Epub 2007 Oct 4.
  • Du YH, Chen AF.  A "love triangle" elicited by electrochemistry: complex interactions among cardiac sympathetic afferent, chemo-, and baroreflexes.  Journal of Applied Physiology.  2007 Jan;102(1):9-10.  Epub 2006 Sep 21.
  • Chen DD, Chen AF.  CuZn superoxide dismutase deficiency: culprit of accelerated vascular aging process.  Hypertension.  2006 Dec;48(6):1026-8.  Epub 2006 Oct 16.
  • Hong H, Zeng JS, Kreulen DL, Kaufman DI, Chen AF.  Atorvastatin protects against cerebral infarction via inhibition of NADPH oxidase-derived superoxide in ischemic stroke.  American Journal of Physiology.  Heart and Circulatory Physiology.  2006 Nov;291(5):H2210-5.  Epub 2006 Jun 9.
  • Chen Y, Chen H, Hoffmann A, Cool DR, Diz DI, Chappell MC, Chen AF, Morris M.  Adenovirus-mediated small-interference RNA for in vivo silencing of angiotensin AT1a receptors in mouse brain.  Hypertension.  2006 Feb;47(2):230-7.  Epub 2005 Dec 27.  Erratum in: Hypertension.  2006 Apr;47(4):e18.

CONTACT INFORMATION

Dr. Alex F. Chen
Phone: (412) 624-6769
Email: chena5@upmc.edu