Robert Bowser, Ph.D.

  • Yu X., Caltagarone, J., Smith, M.A., and Bowser R. (2005). DNA damage induces cdk2 protein levels and histone H2B phosphorylation in SH-SY5Y neuroblastoma cells. J Alz Dis, 8: 7-21.

  • Ranganathan S., Williams E., Ganchev P., Gopalakrishnan V., Urbinelli L., Newhall K., Lacomis, D., Cudkowicz M.E., Brown R.H.Jr., Bowser, R. (2005). Proteomic profiling of cerebrospinal fluid identifies biomarkers for amyotrophic lateral sclerosis. J Neurochem, 95: 1461-1471.

  • Ranganathan S., Polshyna A., Lutka F., Nicholl G., Lyons-Weiler J., and Bowser R. (2006). Assessment of protein stability in cerebrospinal fluid by mass spectrometry based proteomics. Clinical Proteomics, 2: 91-102.

  • Gopalakrishnan V, Ganchev P, Ranganathan S, and Bowser R. (2006). Rule Learning for Disease-specific Biomarker Discovery from Clinical Proteomic Mass Spectra. In BioDM 2006, Lecture Notes in Bioinformatics (LNBI) 3916. J. Li et al. (Eds.) Springer-Verlag, Berlin, Heidelberg, pp 93 - 105.

  • Bowser R., Cudkowicz M., and Kaddurah-Daouk R. (2006). Biomarkers in amyotrophic lateral sclerosis. Expert Rev. Mol. Diagn., 6: 387-398.

  • Kolarcik C., and Bowser R. (2006). Plasma and cerebrospinal fluid-based protein biomarkers for motor neuron disease. Mol. Diag. & Therapy, 10(5): 281-292.

  • Chalovich EM, Zhu J-H, Caltagarone J, Bowser R, and Chu CT. (2006). Functional repression of cAMP response element in 6-hydroxydopamine-treated neuronal cell. J. Biol. Chem., 281: 17870 - 17881.

  • Caltagarone J., Jing Z., and Bowser, R. (2007). Focal adhesions regulate Aß signaling and cell death in Alzheimer’s disease. Biochim et Biophys Acta (BBA) – Molecular Basis of Disease, 1772: 438-445.

  • Wilson, C., Henry, S., Smith, M.A., and Bowser, R. (2004). The p53 homologue p73 accumulates in the nucleus and localizes to neurites and neurofibrillary tangles in Alzheimer disease brain. Neuropath. Appl. Neurobiol., 30: 19-29.

  • Hamilton, R.L., and Bowser, R. (2004). Alzheimer disease pathology in amyotrophic lateral sclerosis. Acta Neuropathologica, 107: 515-522.

  • Zhu, X., McShea, A., Castellani, R., Morelli, L., Harris, P., Bowen, R., Raina, A., Bowser, R., Perry, G., and Smith, M.A. (2004). Elevated Expression of a Regulator of the G2/M Phase of the Cell Cycle, Neuronal CIP-1 Associated Regulator of Cyclin B, in Alzheimer Disease. J. Neurosci. Res., 75: 698-703.

  • Gopalakrishnan, V., Williams, E., Ranganathan, S., Bowser, R., Cudkowicz, M.E., Novelli, M., Lattanzi, W., Gambotto, A., and Day, B.W. (2004). Proteomic data mining challenges in identification of disease-specific biomarkers from variable resolution mass spectra. Proceedings of Bioinformatics Workshop, SIAM Data Mining 2004, Eds. Obradovic, Z., and Komorowski, J., pp. 1-10.

  • Strachan, G.D., Morgan, K.L., Caltagarone, J.M., Gittis, A., Bowser, R., Jordan-Sciutto, K.L. (2004). Fetal Alz-50 Clone 1 (FAC1) interacts with the human homologue of the Kelch-like Ech Associated Protein (Keap1). Biochemistry, 43: 12113-12122.

  • Yu, X., and Bowser, R. (2004). DNA damage induces histone H2B phosphorylation and cdk2 levels in SH-SY5Y neuroblastoma cells. Submitted.

  • Ranganathan, S., Polshyna, A., Lutka, F., Nicholl, G., Lyons-Weiler, J., and Bowser, R. (2004). Assessment of protein stability in cerebrospinal fluid by mass spectrometry based proteomics. Submitted.

CONTACT INFORMATION

Dr. Robert P. Bowser
Phone: (412) 383-7819
Email: bowserrp@upmc.edu