Selected recent publications:

• Donthamsetty S, Bhave VS, Kliment CS, Bowen WC, Mars WM, Bell AW, Stewart RE, Orr A, Wu C, Michalopoulos GK. Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene. Hepatology. 2010 Oct 18 Article first published online: 6 JAN 2011 DOI: 10.1002/hep.24040
• Liu B, Bell AW, Paranjpe S, Bowen WC, Khillan JS, Luo JH, Mars WM, Michalopoulos GK. Suppression of liver regeneration and hepatocyte proliferation in hepatocyte-targeted glypican 3 transgenic mice. Hepatology. 2010 Sep;52(3):1060-7. PMID: 20812357
• Donthamsetty S, Bowen W, Mars W, Bhave V, Luo JH, Wu C, Hurd J, Orr A, Bell A, Michalopoulos G. Liver-specific ablation of integrin-linked kinase in mice results in enhanced and prolonged cell proliferation and hepatomegaly after phenobarbital administration. Toxicol Sci. 2010 Feb;113(2):358-66. Epub 2009 Nov 17.PMID: 19920070
• Liu B, Paranjpe S, Bowen WC, Bell AW, Luo JH, Yu YP, Mars WM, Michalopoulos GK. Investigation of the role of glypican 3 in liver regeneration and hepatocyte proliferation. Am J Pathol. 2009 Aug;175(2):717-24. Epub 2009 Jul 2.PMID: 19574424
• Paranjpe S, Bowen WC, Bell AW, Nejak-Bowen K, Luo JH, Michalopoulos GK. Cell cycle effects resulting from inhibition of hepatocyte growth factor and its receptor c-Met in regenerating rat livers by RNA interference. Hepatology 45(6):1471-1477 2007; PMID: 17427161
• Zhu Z, He X, Johnson C, Stoops J, Eaker AE, Stoffer DS, Bell A, Zarnegar R, Defrances MC. PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein. Biochem Biophys Res Commun. 2007 Jun 22;358(1):66-72. Epub 2007 Apr 24. PMID: 17475214 .
• Zeng G, Apte U, Micsenyi A, Bell A, Monga SP.Tyrosine residues 654 and 670 in beta-catenin are crucial in regulation of Met-beta-catenin interactions. Exp Cell Res. 2006 Nov 1;312(18):3620-30. Epub 2006 Aug 10. PMID: 16952352
• Gang Zeng, Matt Germinaro, Amanda Micsenyi, Navjot K. Monga, Aaron Bell, Ajit Sood, Vanita Malhotra, Neena Sood, Vandana Midda, Dulabh K. Monga, Demetrius M. Kokkinakis, Satdarshan P.S. Monga.  Aberrant Wnt/Beta-Catenin Signaling In Pancreatic Adenocarcinoma. Neoplasia. 2006 Apr;8(4):279-89. PMID: 16756720
• Bell, A. W. and Michalopoulos, G. K. Phenobarbital Induces Nuclear Expression of HNF4 in mouse and rat hepatocytes independent of CAR and PXR. Hepatology. Jul;44(1):186-94 2006. PMID: 16799975
• Monga SP, Micsenyi A, Germinaro M, Apte U, Bell A. beta-Catenin regulation during matrigel-     induced rat hepatocyte differentiation. Cell Tissue Res. ; 323(1): 71-9, 2006 PMID: 16160859
• Tan X, Apte U, Micsenyi A, Kotsagrelos E, Luo JH, Ranganathan S, Monga DK, Bell A, Michalopoulos GK, Monga SP.  Epidermal growth factor receptor: a novel target of the Wnt/beta-catenin pathway in liver. Gastroenterology. 2005 Jul;129(1):285-302 PMID: 16012954
• Kolher, C, Bell, AW, Bowen, WC, Monga, SP, Michalopoulos, GK. Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration.   Hepatology 39(4), 1056-65 2004. PMID: 15057910
• Monga SP, Mars WM, Pediaditakis P, Bell A, Mule K, Bowen WC, Wang X, Zarnegar R, Michalopoulos GK. Hepatocyte Growth Factor Induces Wnt-independent Nuclear Translocation of beta-Catenin after Met-beta-Catenin Dissociation in Hepatocytes. Cancer Res. ;62(7):2064-71 (2002). PMID: 11929826
• Wang X, DeFrances MC, Dai Y, Pediaditakis P, Johnson C, Bell A, Michalopoulos GK, Zarnegar R. A mechanism of cell survival: sequestration of Fas by the HGF receptor Met. Mol Cell. Feb;9(2):411-21 (2002). PMID: 11864613
• Bell, A. W., Chen, Q., DeFrances, M. C., Michalopolous, G. K., Zarnegar, R. The five amino acid-deleted isoform of hepatocyte growth factor promotes carcinogenesis in transgenic mice. Oncogene 18, 887-895 (1999). PMID: 10023664

CONTACT INFORMATION

Dr. Aaron W. Bell
Department of Pathology
University of Pittsburgh
S-451 Bioscience Tower
200 Lothrop Street
Pittsburgh, PA 15213
Phone: (412) 383-8922
Fax: (412) 648-1916
Email: bellaaro@pitt.edu