Selected recent publications:

• Wainwright JM, Hashizume R, Fujimoto KL, Remlinger NT, Pesyna C, Wagner WR, Tobita K, Gilbert TW, Badylak SF.  Right Ventricular Outflow Tract Repair with a Cardiac Biologic Scaffold.  Cells Tissues Organs.  2011 Oct 24.  [Epub ahead of print]

• Daly KA, Liu S, Agrawal V, Brown BN, Johnson SA, Medberry CJ, Badylak SF.  Damage associated molecular patterns within xenogeneic biologic scaffolds and their effects on host remodeling.  Biomaterials.  2011 Oct 1.  [Epub ahead of print]

• Agrawal V, Tottey S, Johnson SA, Freund JM, Siu BF, Badylak SF.  Recruitment of Progenitor Cells by an Extracellular Matrix Cryptic Peptide in a Mouse Model of Digit Amputation.  Tissue Engineering Part A.  2011 Jun 16.

• Hong Y, Takanari K, Amoroso NJ, Hashizume R, Brennan-Pierce EP, Fruend JM, Badylak SF, Wagner W.  An elastomeric patch electrospun from a blended solution of dermal ECM and biodegradable polyurethane for rat abdominal wall repair.  Tissue Engineering Part C. Methods.  2011 Sep 20.  [Epub ahead of print]
• Agrawal V, Kelly J, Tottey S, Daly KA, Johnson SA, Siu BF, Reing J, Badylak SF.  An Isolated Cryptic Peptide Influences Osteogenesis and Bone Remodeling in an Adult Mammalian Model of Digit Amputation.  Tissue Engineering Part A.  2011 Aug 29.  [Epub ahead of print]
• Badylak SF, Taylor D, Uygun K.  Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds.  Annual Review of Biomedical Engineering.  2011 Aug 15;13:27-53.
• Penolazzi L, Mazzitelli S, Vecchiatini R, Torreggiani E, Lambertini E, Johnson S, Badylak SF, Piva R, Nastruzzi C.  Human mesenchymal stem cells seeded on extracellular matrix scaffold: Viability and osteogenic potential.  Journal of Cellular Physiology.  2011 Aug 9.  [Epub ahead of print]

• Huber A, Badylak SF.  Phenotypic changes in cultured smooth muscle cells: limitation or opportunity for tissue engineering of hollow organs?  Journal of Tissue Engineering and Regenerative Medicine.  2011 Jul 14.  [Epub ahead of print]

• Brown BN, Chung WL, Pavlick M, Reppas S, Ochs MW, Russell AJ, Badylak SF.  Extracellular Matrix as an Inductive Template for Temporomandibular Joint Meniscus Reconstruction: A Pilot Study.  Journal of Oral and Maxillofacial Surgery.  2011 Jun 17.

• Turner NJ, Badylak SF.  Regeneration of skeletal muscle.  Cell and Tissue Research.  2011 Jun 11.

• Badylak SF, Hoppo T, Nieponice A, Gilbert TW, Davison JM, Jobe BA.  Esophageal preservation in five male patients after endoscopic inner-layer circumferential resection in the setting of superficial cancer: a regenerative medicine approach with a biologic scaffold.  Tissue Engineering Part A.  2011 Jun;17(11-12):1643-50.  Epub 2011 Mar 28.

• Soto-Gutierrez A, Zhang L, Medberry C, Fukumitsu K, Faulk D, Jiang H, Reing J, Gramignoli R, Komori J, Ross M, Nagaya M, Lagasse E, Stolz D, Strom SC, Fox IJ, Badylak SF.  A whole-organ regenerative medicine approach for liver replacement.  Tissue Engineering Part C Methods.  2011 Jun;17(6):677-86.  Epub 2011 Apr 20.

• Daly KA, Wolf M, Johnson SA, Badylak SF.  A rabbit model of peripheral compartment syndrome with associated rhabdomyolysis and a regenerative medicine approach for treatment.  Tissue Engineering Part C Methods.  2011 Jun;17(6):631-40.  Epub 2011 Apr 12.

• Hong Y, Huber A, Takanari K, Amoroso NJ, Hashizume R, Badylak SF, Wagner WR.  Mechanical properties and in vivo behavior of a biodegradable synthetic polymer microfiber-extracellular matrix hydrogel biohybrid scaffold.  Biomaterials.  2011 May;32(13):3387-94.

• Marongiu F, Gramignoli R, Dorko K, Miki T, Ranade AR, Paola Serra M, Doratiotto S, Sini M, Sharma S, Mitamura K, Sellaro TL, Tahan V, Skvorak KJ, Ellis EC, Badylak SF, Davila JC, Hines R, Laconi E, Strom SC.  Hepatic differentiation of amniotic epithelial cells.  Hepatology.  2011 May;53(5):1719-29.
  

• Crapo PM, Gilbert TW, Badylak SF.  An overview of tissue and whole organ decellularization processes.  Biomaterials.  2011 Apr;32(12):3233-43.  Epub 2011 Feb 5. Review.

• Brown BN, Freund JM, Han L, Rubin JP, Reing JE, Jeffries EM, Wolf MT, Tottey S, Barnes CA, Ratner BD, Badylak SF.  Comparison of three methods for the derivation of a biologic scaffold composed of adipose tissue extracellular matrix.  Tissue Engineering Part C Methods.  2011 Apr;17(4):411-21.  Epub 2011 Feb 5.
  

• Mazzitelli S, Luca G, Mancuso F, Calvitti M, Calafiore R, Nastruzzi C, Johnson S, Badylak SF.  Production and characterization of engineered alginate-based microparticles containing ECM powder for cell/tissue engineering applications.  Acta Biomaterialia.  2011 Mar;7(3):1050-62. Epub 2010 Oct 13.

• Hammond JS, Gilbert TW, Howard D, Zaitoun A, Michalopoulos G, Shakesheff KM, Beckingham IJ, Badylak SF.  Scaffolds containing growth factors and extracellular matrix induce hepatocyte proliferation and cell migration in normal and regenerating rat liver.  Journal of Hepatology.  2011 Feb;54(2):279-87.  Epub 2010 Sep 15.

• Badylak SF, Brown BN, Gilbert TW, Daly KA, Huber A, Turner NJ.  Biologic scaffolds for constructive tissue remodeling.  Biomaterials.  2011 Jan;32(1):316-9.

• Barnes CA, Brison J, Michel R, Brown BN, Castner DG, Badylak SF, Ratner BD.  The surface molecular functionality of decellularized extracellular matrices.  Biomaterials.  2011 Jan;32(1):137-43.  Epub 2010 Nov 4.

• El-Bialy T, Uludag H, Jomha N, Badylak SF.  In Vivo Ultrasound-Assisted Tissue-Engineered Mandibular Condyle: A Pilot Study in Rabbits.  Tissue Engineering Part C. Methods.  2010 Dec;16(6):1315-23. Epub 2010 Apr 26.
• Reing JE, Brown BN, Daly KA, Freund JM, Gilbert TW, Hsiong SX, Huber A, Kullas KE, Tottey S, Wolf MT, Badylak SF.  The effects of processing methods upon mechanical and biologic properties of porcine dermal extracellular matrix scaffolds.  Biomaterials.  2010 Nov;31(33):8626-33.  Epub 2010 Aug 21.

• Turner NJ, Yates AJ, Weber DJ, Qureshi IR, Beer Stolz D, Gilbert TW, Badylak SF.  Xenogeneic extracellular matrix as an inductive scaffold for regeneration of a functioning musculotendinous junction.  Tissue Engineering Part A.  2010 Nov;16(11):3309-17. Epub 2010 Aug 1.

• Allen RA, Seltz LM, Jiang H, Kasick RT, Sellaro TL, Badylak SF, Ogilvie JB.  Adrenal extracellular matrix scaffolds support adrenocortical cell proliferation and function in vitro.  Tissue Engineering Part A.  2010 Nov;16(11):3363-74.  Epub 2010 Aug 11.

• Valentin JE, Turner NJ, Gilbert TW, Badylak SF.  Functional skeletal muscle formation with a biologic scaffold.  Biomaterials.  2010 Oct;31(29):7475-84.  Epub 2010 Jul 17.

• Vorotnikova E, McIntosh D, Dewilde A, Zhang J, Reing JE, Zhang L, Cordero K, Bedelbaeva K, Gourevitch D, Heber-Katz E, Badylak SF, Braunhut SJ.  Extracellular matrix-derived products modulate endothelial and progenitor cell migration and proliferation in vitro and stimulate regenerative healing in vivo.  Matrix Biology.  2010 Oct;29(8):690-700.  Epub 2010 Aug 24.

• Medberry CJ, Tottey S, Jiang H, Johnson SA, Badylak SF.  Resistance to Infection of Five Different Materials in a Rat Body Wall Model.  Journal of Surgical Research.  2010 Sep 17.  [Epub ahead of print]

• Mase VJ Jr, Hsu JR, Wolf SE, Wenke JC, Baer DG, Owens J, Badylak SF, Walters TJ.  Clinical application of an acellular biologic scaffold for surgical repair of a large, traumatic quadriceps femoris muscle defect.  Orthopedics.  2010 Jul 13;33(7):511.

• Boruch AV, Nieponice A, Qureshi IR, Gilbert TW, Badylak SF.  Constructive remodeling of biologic scaffolds is dependent on early exposure to physiologic bladder filling in a canine partial cystectomy model.  Journal of Surgical Research.  2010 Jun 15;161(2):217-25.  Epub 2009 Mar 20.

• Wainwright JM, Czajka CA, Patel UB, Freytes DO, Tobita K, Gilbert TW, Badylak SF.  Preparation of cardiac extracellular matrix from an intact porcine heart.  Tissue Engineering Part C. Methods.  2010 Jun;16(3):525-32.

• Remlinger NT, Czajka CA, Juhas ME, Vorp DA, Stolz DB, Badylak SF, Gilbert S, Gilbert TW.  Hydrated xenogeneic decellularized tracheal matrix as a scaffold for tracheal reconstruction.  Biomaterials.  2010 May;31(13):3520-6.  Epub 2010 Feb 7.
• Derwin KA, Badylak SF, Steinmann SP, Iannotti JP.  Extracellular matrix scaffold devices for rotator cuff repair.  Journal of Shoulder and Elbow Surgery.  2010 Apr;19(3):467-76.  Epub 2010 Feb 26.

• Wang G, Badylak SF, Heber-Katz E, Braunhut SJ, Gudas LJ.  The effects of DNA methyltransferase inhibitors and histone deacetylase inhibitors on digit regeneration in mice.  Regenerative Medicine.  2010 Mar;5(2):201-20.

• Sellaro TL, Ranade A, Faulk DM, McCabe GP, Dorko K, Badylak SF, Strom SC.  Maintenance of human hepatocyte function in vitro by liver-derived extracellular matrix gels.  Tissue Engineering Part A.  2010 Mar;16(3):1075-82.

• Badylak SF, Nerem RM.  Progress in tissue engineering and regenerative medicine.  Proceedings of the National Academy of Sciences U S A.  2010 Feb 23;107(8):3285-6.

• Agrawal V, Johnson SA, Reing J, Zhang L, Tottey S, Wang G, Hirschi KK, Braunhut S, Gudas LJ, Badylak SF.  Epimorphic regeneration approach to tissue replacement in adult mammals.  Proceedings of the National Academy of Sciences U S A.  2010 Feb 23;107(8):3351-5.  Epub 2009 Dec 4.

• Brown BN, Barnes CA, Kasick RT, Michel R, Gilbert TW, Beer-Stolz D, Castner DG, Ratner BD, Badylak SF.  Surface characterization of extracellular matrix scaffolds.  Biomaterials.  2010 Jan;31(3):428-37.  Epub 2009 Oct 13.

• Valentin JE, Freytes DO, Grasman JM, Pesyna C, Freund J, Gilbert TW, Badylak SF.  Oxygen diffusivity of biologic and synthetic scaffold materials for tissue engineering.  Journal of Biomedical Materials Research. Part A.  2009 Dec 15;91(4):1010-7.

• Agrawal V, Brown BN, Beattie AJ, Gilbert TW, Badylak SF.  Evidence of innervation following extracellular matrix scaffold-mediated remodelling of muscular tissues.  Journal of Tissue Engineering. Regenerative Medicine.  2009 Dec;3(8):590-600.

• Witteman BP, Foxwell TJ, Monsheimer S, Gelrud A, Eid GM, Nieponice A, O'Rourke RW, Hoppo T, Bouvy ND, Badylak SF, Jobe BA.  Transoral endoscopic inner layer esophagectomy: management of high-grade dysplasia and superficial cancer with organ preservation.  Journal of Gastrointestinal Surgery.  2009 Dec;13(12):2104-12.  Epub 2009 Oct 14.

• Daly KA, Stewart-Akers AM, Hara H, Ezzelarab M, Long C, Cordero K, Johnson SA, Ayares D, Cooper DK, Badylak SF.  Effect of the alphaGal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model.  Tissue Engineering Part A.  2009 Dec;15(12):3877-88.

• Gilbert TW, Agrawal V, Gilbert MR, Povirk KM, Badylak SF, Rosen CA.  Liver-derived extracellular matrix as a biologic scaffold for acute vocal fold repair in a canine model.  Laryngoscope.  2009 Sep;119(9):1856-63.

• Kelly DJ, Rosen AB, Schuldt AJ, Kochupura PV, Doronin SV, Potapova IA, Azeloglu EU, Badylak SF, Brink PR, Cohen IS, Gaudette GR.  Increased myocyte content and mechanical function within a tissue-engineered myocardial patch following implantation.  Tissue Engineering Part A.  2009 Aug;15(8):2189-201.

• Valentin JE, Stewart-Akers AM, Gilbert TW, Badylak SF.  Macrophage participation in the degradation and remodeling of extracellular matrix scaffolds.  Tissue Engineering Part A.  2009 Jul;15(7):1687-94.

• Parekh A, Mantle B, Banks J, Swarts JD, Badylak SF, Dohar JE, Hebda PA.  Repair of the tympanic membrane with urinary bladder matrix.  Laryngoscope.  2009 Jun;119(6):1206-13.

• Beattie AJ, Gilbert TW, Guyot JP, Yates AJ, Badylak SF.  Chemoattraction of progenitor cells by remodeling extracellular matrix scaffolds.  Tissue Engineering Part A.  2009 May;15(5):1119-25.

• Brown BN, Valentin JE, Stewart-Akers AM, McCabe GP, Badylak SF.  Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component.  Biomaterials.  2009 Mar;30(8):1482-91.  Epub 2009 Jan 1.

• Gilbert TW, Freund JM, Badylak SF.  Quantification of DNA in biologic scaffold materials.  Journal of Surgical Research.  2009 Mar;152(1):135-9.  Epub 2008 Mar 13.

• Reing JE, Zhang L, Myers-Irvin J, Cordero KE, Freytes DO, Heber-Katz E, Bedelbaeva K, McIntosh D, Dewilde A, Braunhut SJ, Badylak SF.  Degradation products of extracellular matrix affect cell migration and proliferation.  Tissue Engineering Part A.  2009 Mar;15(3):605-14.

• Badylak SF, Freytes DO, Gilbert TW. Extracellular matrix as a biological scaffold material: Structure and function.  Acta Biomaterialia.  2009 Jan;5(1):1-13. Epub 2008 Oct 2.

• Gilbert TW, Wognum S, Joyce EM, Freytes DO, Sacks MS, Badylak SF.  Collagen fiber alignment and biaxial mechanical behavior of porcine urinary bladder derived extracellular matrix.  Biomaterials.  2008 Dec;29(36):4775-82.  Epub 2008 Sep 17.

• Brennan EP, Tang XH, Stewart-Akers AM, Gudas LJ, Badylak SF.  Chemoattractant activity of degradation products of fetal and adult skin extracellular matrix for keratinocyte progenitor cells.  Journal of Tissue Engineering and Regenerative Medicine.  2008 Dec;2(8):491-8.

• Freytes DO, Tullius RS, Valentin JE, Stewart-Akers AM, Badylak SF.  Hydrated versus lyophilized forms of porcine extracellular matrix derived from the urinary bladder.  Journal of Biomedical Materials Research Part A.  2008 Dec 15;87(4):862-72.

• Ota T, Gilbert TW, Schwartzman D, McTiernan CF, Kitajima T, Ito Y, Sawa Y, Badylak SF, Zenati MA.  A fusion protein of hepatocyte growth factor enhances reconstruction of myocardium in a cardiac patch derived from porcine urinary bladder matrix.  Journal of Thoracic and Cardiovascular Surgery.  2008 Nov;136(5):1309-17.  Epub 2008 Sep 14.

• Badylak SF, Valentin JE, Ravindra AK, McCabe GP, Stewart-Akers AM.  Macrophage phenotype as a determinant of biologic scaffold remodeling.  Tissue Engineering Part A.  2008 Nov;14(11):1835-42.

• Beattie AJ, Gilbert TW, Guyot JP, Yates AJ, Badylak SF.  Chemoattraction of Progenitor Cells by Remodeling Extracellular Matrix Scaffolds.  Tissue Engineering Part A.  2008 Oct 6.

• Gilbert TW, Gilbert S, Madden M, Reynolds SD, Badylak SF.  Morphologic assessment of extracellular matrix scaffolds for patch tracheoplasty in a canine model.  Annals of Thoracic Surgery.  2008 Sep;86(3):967-74;  discussion 967-74.

• Nieponice A, McGrath K, Qureshi I, Beckman EJ, Luketich JD, Gilbert TW, Badylak SF.  An extracellular matrix scaffold for esophageal stricture prevention after circumferential EMR.  Gastrointestinal Endoscopy.  2008 Jul 25.

• Reing JE, Zhang L, Myers-Irvin J, Cordero KE, Freytes DO, Heber-Katz E, Bedelbaeva K, McIntosh D, Dewilde A, Braunhut SJ, Badylak SF.  Degradation Products of Extracellular Matrix Affect Cell Migration and Proliferation.  Tissue Engineering Part A.  2008 Jul 24.

• Gilbert TW, Badylak SF, Gusenoff J, Beckman EJ, Clower DM, Daly P, Rubin JP.  Lysine-derived urethane surgical adhesive prevents seroma formation in a canine abdominoplasty model.  Plastic and Reconstructive Surgery.  2008 Jul;122(1):95-102.

CONTACT INFORMATION

Stephen F. Badylak, DVM, PhD, MD
Phone: 412-624-5253
Email: badylaks@upmc.edu
Lab Website: www.mirm.pitt.edu/badylak/