Amino Acid-Based Polyurethanes for Tissue Engineering
Polyurethanes offer extraordinary versatility
and are used in many applications, including: thermoplastics
for automotive applications, organic and water-borne coatings,
foams for seat cushions and insulation, fibers, thermoplastic
elastomers (Lycra, etc.) and thermosets.
Dr.
Beckman, in collaboration with
Dr.
Agarwal (School of Dentistry) and an accomplished research
team, has generated novel, non-toxic, biodegradable peptide-based
urethane polymers that have been successfully evaluated
using rabbit bone marrow cells. These polyurethane foams,
made from lysine, glycerol, sugar and tyrosine, support
the growth of osteoblasts and biodegrade over a period of
time to non-toxic materials. As research progresses, these
materials are showing increased promise as bone-tissue engineering
scaffolds. Ultimately, these findings are an exciting precursor
to the use of these innovative materials in human reconstructive
surgical procedures.


Rabbit bone cells grown on the LDI-glucose
polymer
for 8 hours (left) and 7 days (right) show the polymer
has attached to the cells and has spread
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The novel technology being developed in this project may help usher in a next
generation of smaller and more efficient implantable artificial lungs. This new
line of device would be constructed from artificial alveolar capillary
modules that mimic the microvascular exchange units found in nature. The improved
implantable artificial lung would then be of a smaller size, but would retain
significant surface area for gas exchange and a gas exchange efficiency that
approaches that of the natural lung.