Dr. Wilson Meng received his PhD in Pharmaceutical Sciences from the University of Southern California. After completing a postdoctoral fellowship at the UCLA School of Medicine, he joined Duquesne University in 2001. He is currently an Associate Professor of Pharmaceutical Sciences at Duquesne. Dr. Meng graduated from the University of Maryland School of Pharmacy and practiced pharmacy in Maryland and California.
Dr. Meng was a visiting scientist at the Molecular Biosensor and Imaging Center at Carnegie Mellon University. He has served as grant reviewer for the National Institutes of Health, The Wellcome Trust (UK), and the National Science Foundation. He is an assistant editor for the Journal of Pharmaceutical Innovation (Springer), and served as a guest editor for Clinical Immunology (Elsevier).
Research in the Meng lab focuses on designing and characterization of inspired drug delivery systems for modulating immune functions. Some examples include:
The group is investigating the use of injectable films in extending the bioavailability of antibody drugs in subcutaneous tissues (Zheng et al, 2011; Wen et al, 2013, Saunders et al., 2013, 2014a, 2014b; Liu et al., 2016; funded by PA-CURE and the NIH).
The lab has developed nano- and micro-particles that combine several biodegradable polymers as carriers for formulating nucleic acids as drugs (Chamarthy et al., 2003, 2004; Kovacs et al., 2005; Zheng et al., 2006; Jia et al., 2006, 2008; Kovacs et al., 2009). The platform has been tested in mouse skin transplant models (funded by NIH).
In collaboration with Drs. Nick Giannoukakis of the Allegheny-Singer Research Institute (ASRI), the group is developing nanostructures for delivering immune modulators in delaying the onset of type-I diabetes in mouse models (funded by JDRF and NIH SBIR). Working with Dr. Yong Fan, also of ASRI, the lab is engineering artificial thymic organoids to reprogram T cells (funded by NIH).
The group maintains a strong interest in MHC bioinformatics and T cell epitope prediction (Joseph et al., 2007, Andrick et al., 2015).
View a list of Dr. Meng’s publications here.