Dr. Sohail Husain is a Pediatric physician-scientist. He serves as an Associate Professor of Pediatrics at the University of Pittsburgh and Director of the Exocrine Pancreas Research Program at the Children’s Hospital of Pittsburgh of UPMC. He earned an MD degree at Tufts University School of Medicine and matriculated through a Pediatric residency at New York University Medical Center. Dr. Husain developed a passion for Pediatric gastroenterology as a fellow at Yale University. While at Yale, he became entrenched in a quest to decipher the mechanisms underlying various pancreatitis disorders and to devise novel therapies for them. These disorders include pancreatitis and pancreatic insufficiency. His work was the first to identify a pathological role for pancreatic acinar cell calcium release through the intra-cellular calcium channel the ryanodine receptor.
In 2011, Dr. Husain came to the University of Pittsburgh. Here at Pitt he has discovered that a crucial pathological target of calcium signaling in pancreatitis is the calcium-activated phosphatase calcineurin. Currently, his lab group investigates three broad areas related to the exocrine pancreas: (1) The crucial signaling pathways that initiate and transduce pancreatitis; (2) the factors that turn on pancreatic regeneration and recovery after pancreatic injury; and (3) the mechanisms underlying drug-induced pancreatitis.
Building upon a cohort of children with pancreatitis and more recently through a collaborative multi-center Pediatric consortium called INSPPIRE (the International Study Group of Pediatric Pancreatitis: In Search for a Cure), Dr. Husain has also published work that provides a novel description of the presentation, evaluation, and trends among affected children.
Dr. Husain has authored 70 scientific papers, 10 book chapters, and has filed several patents related to pancreatic disorders. He holds two R01 research grants from the NIH, where he serves as a standing member of a study section. He serves as Chair of the Pancreas Committee of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) and a Councilor on the Pancreatic Disorders Section of the American Gastroenterological Association (AGA). He serves as Chair of the AGA Pancreatitis Inflammation, Fibrogenesis, and Immunology Committee. He is a member of the American Pancreatic Association and a Board Member of the Western Pennsylvania Chapter of the National Pancreas Foundation.
Combined with an expertise in examining the molecular pathogenesis of pancreatic disorders and the clinical entity among children, Dr. Husain’s long-term goals are to come up with novel, targeted therapies for pancreatic disorders.
View a list of Dr. Husain’s publications here.