Dr. Michael Pezzone is an Adjunct Associate Professor in the Department of Pharmacology & Chemical Biology at the University of Pittsburgh School of Medicine. He is also a Clinical Preceptor in Gastroenterology & Hepatology, Department of Physician Assistant Studies, Duquesne University.
Dr. Pezzone is a Staff Physician at several Pennsylvania hospitals: Washington Hospital, Washington, St. Clair Hospital, Pittsburgh, and six Pittsburgh UPMC hospitals. Dr. Pezzone’s clinical practice includes general gastroenterology, pancreaticobiliary, motility, functional bowel disorders, inflammatory bowel disease, and the treatment of liver diseases.
Dr. Pezzone attended Cornell University as an undergraduate where he majored in both Chemistry and Biochemistry. While at Cornell, he successfully completed an honors thesis studying structure-activity relationships in glycosidase inhibitors looking at the mechanisms of carbohydrate metabolism. Dr. Pezzone continued his education through studies of an autoimmune basis of schizophrenia and developed an interest in immune function and auto-immune disorders as a Mellon Fellow in Psychiatry at the Western Psychiatric Institute and Clinic, and as a member of the Division of Immunopathology at the University of Pittsburgh School of Medicine.
After completion of his first 2 years of medical school, Dr. Pezzone spent 3 years in the laboratory of Bruce Rabin, MD, PhD, obtaining his PhD from the Department of Pathology. During that time, Dr. Pezzone primarily studied the neural and endocrine effects of stress upon the immune system. After completing medical school, Dr. Pezzone completed both his residency in Internal Medicine and fellowship in Gastroenterology and Hepatology at UPMC. He then began to apply his interests in brain-immune interactions and stress to the gastrointestinal and lower urinary tracts. Dr. Pezzone has received funding from the National Institute of Health in the form of a Mentored Clinical Scientist Development Award and an R01. He also participates in several clinical trials and investigator-initiated pharmaceutical trials.
Dr. Pezzone’s current research interests include:
Novel methods to modulate pain
Novel methods to control inflammation in the colon and bladder
Biomechanical properties of the colon and lower urinary tract
Brain-gut-immune interactions in gastrointestinal disorders
Stress effects on the brain-gut axis and inflammatory bowel disorders
Visceral afferents in the gastrointestinal and urinary tracts and their role in visceral hyperalgesia
Pelvic floor dysfunction and combined colonic and bladder hyperalgesia
Chronic pelvic pain and the overlap of chronic pelvic pain disorders
Dr. Pezzone is a referee for the following journals: American Journal of Physiology, Brain, Behavior, and Immunity, Brain Research, Gastroenterology,Journal of Anatomy, Journal of Neuroscience, Journal of Spinal Cord Medicine, Pain, Urology, and the World Journal of Gastroenterology. Dr. Pezzone is a sought-after presenter and the author of numerous abstracts, book chapters/reviews, and referred articles. He is a Fellow of the American Gastroenterological Association and he has been named a top doctor annually by Castle Connolly since 2008.
View a list of Dr. Pezzone’s publications here.