Dr. Hang Lin is a Research Assistant Professor, Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, School of Medicine, University of Pittsburgh.
Dr. Lin received a BS in Biochemistry from the Nanjing University, Nanjing, P.R.China. He received a PhD in Cell Biology from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, P.R.China.
From 2008-2010, Dr. Lin was a Visiting Fellow at the National Institute of Arthritis and Musculoskeletal and Skin, National Institutes of Health, Bethesda, MD. He has been with the University of Pittsburgh since 2010, as a Postdoctoral Associate and a Research Instructor. In 2017, he received the University of Pittsburgh Innovator Award. He currently holds 4 patents.
Dr. Lin is a member of the Orthopaedic Research Society, the Biomedical Engineering Society, and the Tissue Engineering and Regenerative Medicine International Society. In addition to being an Editorial Board Member of the Frontiers in Bioengineering and Biotechnology – TE&RM, he is also a reviewer for several journals, including but not limited to, Biomaterials, Tissue Engineering, Journal of Materials Chemistry B, and Stem Cell Research and Therapy.
Dr. Lin’s research interests focus on the study of articular joint diseases and the development of efficacious treatments to regenerate injured tissues. For example, he had developed a method to apply visible light-based projection stereolithography (3D printing) on live cell fabrication. These 3D printed constructs can be further activated through the inclusion of vectors carrying therapeutic factors (Gene-activated matrix/scaffold). Working with other collaborators, he had developed micro-physiological osteochondral tissues (mOCs) in vitro, which offer novel capabilities for investigating the physiology of osteochondral tissue and the pathogenic mechanisms of osteoarthritis (OA), and serving as a high-throughput platform to test potential drugs for OA treatment. Currently, his lab is divided into 3 branches, which are interconnected but target different scientific questions:
Tissue chip modeling of synovial joint pathologies: effects of inflammation and adipose-mediated diabetic complications
Mechanisms of MSC responses to substrate rigidity of scaffolds: enhancing cell quality for tissue regeneration
Effect of chondrocyte aging on their regeneration potential and OA pathology