Dr. Chien Ho is an Alumni Professor of Biological Sciences, Department of Biological Sciences, Carnegie Mellon University (CMU) as well as the director of the Pittsburgh Nuclear Magnetic Resonance (NMR) Center for Biomedical Research which is jointly sponsored by the University of Pittsburgh and CMU. The Pittsburgh NMR Center is funded by a grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) as a Biomedical Technology Research Center (P41 EB001977). Its mission is to advance state-of-the-art in vivo magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques to better understand tissue and organ function and to make these tools available to the greater biomedical research community.
Dr. Ho earned a PhD from Yale University in 1961 and completed his postdoctoral training at the Massachusetts Institute of Technology. A former recipient of the National Heart, Lung and Blood Institute MERIT Award, Dr. Ho is a member of Academia Sinica and actively involved in research efforts rooted in understanding the relationship between structure and function in biological systems. This is made possible by correlating information obtained from biochemical, biophysical, and molecular biological techniques. In 2013, Dr. Ho was named a Fellow of the International Society for the Magnetic Resonance in Medicine (ISMRM) and also received its Gold Medal Award.
Dr. Ho has two major research projects currently underway:
The study of human normal and mutant hemoglobins in order to understand the molecular mechanism of transport of oxygen from the lungs to the tissues: The team has constructed an expression plasmid to produce unmodified human normal adult hemoglobin (Hb) in Escherichia coli. With this expression system, they can design and express any mutant hemoglobins needed for the research on the structure-function relationship in hemoglobin. This hemoglobin research is an excellent illustration of the power of combining information obtained from X-ray crystallography, NMR spectroscopy, computer modeling, molecular genetics, and functional studies to correlate the structure-dynamics-function relationship of an allosteric protein under physiological conditions at atomic resolution.
The application of NMR to living systems, both by imaging (MRI) and by spectroscopic (MRS) methods: Currently, Dr. Ho and his team are developing techniques to monitor the migration of immune cells in vivo by magnetic resonance using dextran-coated superparamagnetic iron oxide particles as contrast agents.
Dr. Ho is a member of the following professional societies:
American Chemical Society
American Society of Biochemistry and Molecular Biology
International Society of Magnetic Resonance in Medicine
The Protein Society
American Association for the Advancement of Science
Sigma Xi Society
Society for Cardiovascular Magnetic Resonance
International Society of Magnetic Resonance
View a partial list of Dr. Ho’s publications here.
Dr. Ho’s ORCID ID: ORCID.org/0000-0002-4094-9232.