Dr. Carl Lagenaur is an Associate Professor of Neurobiology at the University of Pittsburgh and holds a PhD in Biochemistry from the University of Washington, Seattle, Washington. His postdoctoral training was done at the University of Heidelberg Institute of Neurobiology, Baden-Württemberg, Germany. He was a recipient of an NIH postdoctoral fellowship.
Dr. Lagenaur's research interests center on cell recognition events that are important in synapse formation and function. The laboratory is currently studying two cell adhesion molecules, SIRP and CD47, which bind to one another and are localized to sites of synaptic contact. Both molecules have signaling capabilities and may be involved in regulation of synaptic plasticity.
The goal of the laboratory's research is to determine how SIRP and CD47 signaling modify synaptic function. Work in collaboration with Drs. Tracy Cui and Douglas Weber, Department of Bioengineering, explore the use of neural cell adhesion molecules to improve bio-compatibility of chronic neural implants.
Trainees in Dr. Lagenaur's Laboratory have the opportunity to learn a variety of molecular and cell biological techniques such as cell culture, video microscopy, in situ hybridization, and immunochemical techniques for investigating biochemistry of signal transduction molecules in the central nervous system.
Dr. Lagenaur is a member of the Society for Neuroscience and the American Association for the Advancement of Science.
View a list of Dr. Lagenaur’s publications here.