Dr. Andrew Duncan is an Assistant Professor in the Department of Pathology at the University of Pittsburgh. He holds a secondary appointment in the Department of Bioengineering of the Swanson School of Engineering at Pitt. In addition, he is a member of the University of Pittsburgh Graduate Faculty, Program in Cellular and Molecular Pathology, and also a member of the University of Pittsburgh Cancer Institute, Molecular and Cellular Cancer Biology Program.
Dr. Andrew Duncan joined the University of Pittsburgh in 2012 as Assistant Professor in the Department of Pathology, Division of Experimental Pathology. Dr. Duncan graduated from the University of North Carolina at Chapel Hill with a BS in Biology in 1996. He attended graduate school at Duke University where he earned a PhD in 2005. Dr. Duncan's graduate work focused on hematopoietic stem cell biology in Dr. Tannishtha Reya's Laboratory in the Department of Pharmacology and Cancer Biology. From 2005 to 2011, Dr. Duncan was a postdoctoral fellow in Dr. Markus Grompe's Lab in the Oregon Stem Cell Center, Oregon Health and Science University. As a NIH National Research Service Award Fellow, he investigated liver regeneration.
Dr. Duncan’s current research interests include liver development, regeneration, and stem cells, cell cycle regulation and division, liver cancer, cancer stem cells, cellular reprogramming, and cell fusion. Research in the Duncan Lab focuses on liver development, homeostasis, and regeneration.
One of the defining features of the liver is polyploidy. Hepatocytes are either mononucleated or binucleated, and ploidy is determined by the number of nuclei per cell as well as the ploidy of each nucleus. The functional role of hepatic polyploidization is unclear. Dr. Duncan recently showed that regenerating polyploid hepatocytes undergo specialized cell divisions to form aneuploid daughter cells, generating a high degree of genetic diversity within the liver. Active studies in his lab involve elucidating mechanisms that control hepatic polyploidy and aneuploidy, as well as how these processes affect human disease.
Dr. Duncan is on the Editorial Board of Organogenesis and is an ad hoc reviewer for these journals and more: American Journal of Pathology,Hepatology, The Journal of Clinical Investigation, and Cancer Research.
View a list of Dr. Duncan’s publications here.