Dr. Alejandro Soto-Gutiérrez is an Assistant Professor (Tenure Track) in the Department of Pathology at the University of Pittsburgh. He is also an affiliated faculty member of the McGowan Institute, Children's Hospital of Pittsburgh of UPMC, and the Thomas E. Starzl Transplantation Institute (STI). Prior to this he was a Surgery Research Fellow with the Department of Surgery at Massachusetts General Hospital, Harvard Medical School, and the Shriners Hospitals for Children in Boston.
Dr. Soto-Gutiérrez earned his medical degree at the University of Guadalajara, Mexico. While working on his doctorate, he completed a Surgical Fellowship at the Department of Surgery of Okayama University Graduate School of Medicine and Dentistry, Japan, where he wrote his dissertation on liver tissue engineering. He won the 2008 Clinical Research Award for a Post-Graduate Fellow in Transplantation from the New England Organ Bank, the 2009 Thomas E. Starzl, MD Postdoctoral Research Award from the American Liver Foundation, the 2012 Faculty Development Award from the American Society of Transplantation, and the 2013 Competitive Medical Research Fund Program Award from UPMC Health System. He has been awarded a National Institutes of Health Pathway to Independence Award (K99/R00). He is the Editor-in-Chief of the scientific journal, Organogenesis, and Chief Science Coordinator at Solving Organ Shortage (SOS) organization. He is author of more than 70 peer-reviewed publications, 8 book chapters, and edited a book on methods in cell transplantation.
Dr. Soto-Gutierrez's research is focused on the development of new technologies for organ replacement using regenerative medicine approaches (bioengineering, cell transplantation, and organ engineering) to generating entire replacement organs. Dr. Soto-Gutierrez's laboratory uses the structural connective tissue of discarded livers as a scaffold for growing new liver tissue for transplantation and primary liver isolated cells. His laboratory is actively working in liver cell differentiation and understanding hepatic maturation of ES or iPS cells using interactions with liver non-parenchymal liver cells, 3D liver matrix, and different molecules. While portions of the studies are carried out in organ culture systems, several ongoing studies are performed in special animal models of liver regeneration to understand hepatic tissue assembling and regeneration using auxiliary partial orthotopic liver transplantation (APOLT). In addition, Dr. Soto-Gutierrez's laboratory is also interested in strategies for liver repopulation and the study and generation of liver regeneration in disease state models (e.g. acute or chronic liver failure and liver steatosis using metabolic engineering techniques). To this end, several lines of collaboration are open with different laboratories in the Department of Pathology and Surgery.
View Dr. Soto-Gutiérrez‘s publications here.