October 2015 | VOL. 14, NO. 10 | www.McGowan.pitt.edu
Working with gut stem cells from humans and mice, scientists from the Johns Hopkins Children’s Center and the University of Pittsburgh have successfully grown healthy intestine atop a 3-D scaffold made of a substance used in surgical sutures. In a further step that takes their work well beyond proof of concept, McGowan Institute for Regenerative Medicine deputy director Stephen Badylak, DVM, PhD, MD, Pitt graduate students Jenna Dziki and Timothy Keane, and researchers report their laboratory-created intestine successfully regenerated gut tissue in the colons of pre-clinical animals with missing gut lining.