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Carbonic Anhydrase Research (PRAC sub-project)

  • The limiting factor in CO2 elimination is physiological, since over 90% of CO2 in blood is carried as HCO3- (bicarbonate)
  • Carbonic anhydrase (CA) catalyzes the dehydration of HCO3- to CO2
  • Enhanced CO2 removal can be realized through CA coatings for Hollow Fiber Membranes

Questions about this project, please contact David Arazawa at arazawad@upmc.edu

Hattler Catheter

  • Intravenous catheter composed of hollow fiber membranes
  • Incorporates mechanisms for creating efficient gas exchange
  • Partial breathing support independent of the lungs
  • Treatment of patients with short term reversible lung failure

Questions about this project, please contact William Federspiel at federspielwj@upmc.edu

Impeller Percutaneous Respiratory Assist Catheter (iPRAC)

  • Intravenous catheter composed of hollow fiber membranes
  • Internal rotating impellers enhance gas exchange efficiency
  • Partial breathing support independent of the lungs
  • Treatment of patients with short term reversible lung failure

Questions about this project, please contact Garrett Jeffries at  jeffriesrg@upmc.edu

Paracorporeal Respiratory Assist Lung (PRAL)

  • Wearable external device with a rotating fiber bundle
  • Rotating fiber bundle provides efficient gas exchange and pumping ability
  • Offers increased breathing support compared to respiratory catheter
  • Requires relatively low blood flow rates: respiratory dialysis

Questions about this project, please contact William Federspiel at federspielwj@upmc.edu

Rotational Percutaneous Respiratory Assist Catheter (Roto-PRAC)

  • Intravenous catheter composed of hollow fiber membranes
  • Internal rotating impellers enhance gas exchange efficiency
  • Partial breathing support independent of the lungs
  • Treatment of patients with short term reversible lung failure

Questions about this project, please contact Garret Jeffries at jeffriesrg@upmc.edu.

Biohybrid Artificial Lung

  • Composed of microfabricated units that mimic exchange sacs of natural lungs
  • Vascular cells coat blood pathways for improved blood biocompatibility
  • Compact respiratory device design compared to traditional respiratory devices

Questions about this project, please contact William Federspiel at federspielwj@upmc.edu

Oxygen Depletion Device (ODD)
Anaerobically Stored Red Blood Cells with Extended Shelf Life

  • Develop a novel blood storage system that will extend the shelf life of additive system red cell units
  • Deliver red cells of higher efficacy and lower toxicity for transfusion therapy
  • Red cells are stored in a modified additive solution under oxygen-depleted condition (anaerobic storage).

Polymer, Fiber and Surface Modifications

  • Fiber polymer coatings for improved blood biocompatibility
  • Attachment of biomolecules on fibers to provide novel functionality
  • Coatings of active polymeric microspheres on membrane surfaces

Questions about this project, please contact Heung Oh
at ohh@upmc.edu

Systems Engineering of a Pheresis Intervention for Sepsis (SEPsIS) Hemoadsorption Device

  • Extracorporeal blood purification device that removes the inflammatory molecules which cause severe sepsis
  • Device packed with adsorbing polymer beads covered in biocompatible coating
  • Cytokines involved in sepsis adsorbed on beads

Questions about this project, please contact Morgan DiLeo at dileomv@upmc.edu
Updated 22-dec-10

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