Musculoskeletal Research Center
The center was established in 1990 for the purpose of developing integrated programs on orthopaedic education and research. The MSRC is a flourishing enterprise where engineers, scientists and physicians get together with the help of a dedicated staff, to guide and teach highly qualified students, research fellows and residents. The MSRC has newly relocated to the Center for Bioengineering, 300 Technology Drive. Our research is focused in three areas: 1) functional tissue engineering, 2) mechanobiology and 3) robotics and computational biomechanics. Our laboratories, namely Mechanobiology, Tissue Mechanics, Anterior Cruciate Ligament, and Shoulder Dynamics are organized to focus our research efforts on these three areas. The Center has earned a national and international reputation of excellence in basic and clinical research. Over two thousand visitors have toured the facilities and interacted with our research teams.1. Woo, S.L-Y., Jia, F., Zou, L., and Gabriel, M.: Functional Tissue Engineering for Ligament Healing: Potential of Antisense Gene Therapy, in Annals of Biomedical Engineering, 2nd Special Edition on Musculoskeletal Bioengineering, 32(3):342-351, 2004. 2. Musahl, V., Abramowitch, S., Gilbert, T., Tsuda, E., Wang, J.H-C., and Woo, S.L-Y.: The Use of Porcine Small Intestinal Submucosa to Enhance the Healing of the Medial Collateral Ligament - A Functional Tissue Engineering Study in Rabbits. J. of Orthopaedic Research, 22:214-220, 2004. 3. Debski RE, Weiss JA, Newman WJ, Moore SM, McMahon PJ: Stress and Strain in the Anterior Band of the Inferior Glenohumeral Ligament during a Simulated Clinical Examination. J. of Shoulder and Elbow Surgery, 14S:24-31, 2005. 4. Woo, S.L-Y., Kenmore, A., Zeminski, J., Yagi, M., Papageorgiou, C. and Fu, F.H.: The Effectiveness of Anterior Cruciate Ligament Reconstruction by Hamstrings and Patellar Tendon: A Cadaveric Study Comparing Anterior Tibial Load vs. Rotational Loads. J. of Bone and Joint Surgery, 84A(6):907-914, 2002. |
The Musculoskeletal Research
Center (MSRC) is under the leadership of Savio L.Y. Woo,
PhD and is a component of the Engineered Tissue Mechanics Laboratory
 The Laboratory is under
the leadership of Michael Sacks, PhD and it’s primary
research focus is quantitative tissue microstructure-mechanical
property relationships in biologically derived and tissue-engineered
tissues used in bioprosthetic heart valves, bladder, skin
and other applications. In the course of the Laboratory’s
research, the Laboratory has also developed unique instrumentation
for multiaxial mechanical property testing of soft biological
tissues and a novel small angle light scattering (SALS) device
for rapid quantification of collagen fiber architecture.
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