• Pitt
  • Health Sciences
  • UPMC
Regenerative Medicine at the McGowan InstituteRegenerative Medicine at the McGowan InstituteRegenerative Medicine at the McGowan InstituteRegenerative Medicine at the McGowan Institute
  • Home
  • Our People
    • Faculty/Staff Bios (A-C)
    • Faculty/Staff Bios (D-I)
    • Faculty/Staff Bios (J-N)
    • Faculty/Staff Bios (O-S)
    • Faculty/Staff Bios (T-Z)
    • Core Faculty Publications
    • Administrative Resources
  • Our Innovations
    • Impact
    • Patent Matrix
    • Featured Innovations
      • Innovation Insights
      • Coulter Programs
      • Expert Exposés
      • Spinout Spotlight
    • Partnerships & Collaborations
      • Industry
      • Academia
      • Within Pitt
    • Contact
  • About Us
    • Welcome
    • Video
    • Statistics
    • Mission Statement
    • What Is Regenerative Medicine?
    • Contact Us
    • Clinical Site
  • Our Research
    • Focus Areas
      • Tissue Engineering and Biomaterials
      • Cellular Therapies
      • Medical Devices and Artificial Organs
      • Clinical Translation
    • Matrix
    • Centers
    • Laboratories
    • Clinical Trials
    • Initiatives
  • Media
    • Current News
    • News Archive
    • Video
    • Podcasts
    • Newsletter
    • Grant of the Month
    • Publication of the Month
    • Media Contact
    • Video Links
  • Professional Development
    • Seminar Series
    • Special Events
    • Student Interest Groups
    • CATER
    • Post-Doctoral Opportunities
    • Career Opportunities
    • Wiegand Summer Internship
    • Admissions
    • Summer School
    • 2019 Scientific Retreat
    • Human Performance Optimization Symposium

Publication of the Month 2014

Publication of the Month
Media Publication of the Month 2014

Publication Of The Month | December 2014

By The McGowan Institute For Regenerative Medicine | Publication of the Month, Publication of the Month 2014 | July 30, 2015
Authors: Sayan Basu, Andrew J. Hertsenberg, Martha L. Funderburgh, Michael K. Burrow, Mary M. Mann, Yiqin Du, Kira L. Lathrop, Fatima N. Syed-Picard, Sheila M. Adams, David E. Birk, James L. Funderburgh.

Title: Human limbal biopsy–derived stromal stem cells prevent corneal scarring

Summary: Our corneas—transparent, collagen-based structures that allow us to see—are easily damaged by trauma and infection, resulting in scarring and, in many cases, blindness. Although corneal transplant is the clinical norm, adverse immune responses and a shortage of cornea donors are serious limitations. Basu and colleagues devised a personalized cell-based, nonsurgical approach to prevent corneal scarring. They obtained mesenchymal stem cells from the human limbus (the region between the cornea and the sclera) and confirmed that they could be differentiated into keratocytes (corneal cells) in vitro. The human limbal biopsy–derived stromal cells, or LBSCs, were then placed in a fibrin gel and applied to the surface of debridement wounds in mice. The LBSCs were able to regenerate damaged stromal tissue in the animals, resembling native corneal tissue. Because these cells can be obtained directly from the patient and because fibrin-based products are already used in people, this approach could translate soon to treat stromal scarring, a major cause of corneal blindness.

Read More

Publication Of The Month | November 2014

By The McGowan Institute For Regenerative Medicine | Publication of the Month, Publication of the Month 2014 | July 30, 2015
Authors: Aaron D. DeWard, Julie Cramer, Eric Lagasse.

Title: Cellular Heterogeneity in the Mouse Esophagus Implicates the Presence of a Nonquiescent Epithelial Stem Cell Population

Read More

Publication Of The Month | October 2014

By The McGowan Institute For Regenerative Medicine | Publication of the Month, Publication of the Month 2014 | July 30, 2015
Authors: Fedorchak MV, Conner IP, Medina CA, Wingard JB, Schuman JS, Little SR.

Title: 28-day intraocular pressure reduction with a single dose of brimonidine tartrate-loaded microspheres

Read More

Publication Of The Month | September 2014

By The McGowan Institute For Regenerative Medicine | Publication of the Month, Publication of the Month 2014 | July 30, 2015
Authors: Chou CH, Sinden JD, Couraud PO, Modo M.

Title: In vitro modeling of the neurovascular environment by coculturing adult human brain endothelial cells with human neural stem cells.

Read More

Publication Of The Month | August 2014

By The McGowan Institute For Regenerative Medicine | Publication of the Month, Publication of the Month 2014 | July 30, 2015
Authors: Pratyush Dayal, Olga Kuksenok, and Anna C. Balazs.

Title: Directing the Behavior of Active, Self-Oscillating Gels with Light

Summary: In the biological realm, light can act as a powerful stimulus, promoting both positive and negative phototaxis. Using computational modeling, we attempt to design systems that display analogous biomimetic behavior by exhibiting directed, autonomous motion in response to light. We specifically focus on polymer gels that undergo the oscillating Belousov–Zhabotinsky (BZ) reaction and thus manifest periodic chemomechanical pulsations, which can be modulated with light. Reviewing our recent computational studies, we describe how long, rectangular samples of BZ gels, or “worms”, can perform self-sustained movement and via a distinct form of negative phototaxis migrate along complex paths under nonuniform illumination. When the ends of multiple rectangular BZ gels are anchored to a surface, the dynamic behavior of the cilia-like layer can be tuned by light to resemble the motion of a keyboard. With BZ gel pieces that move freely on a surface, we show that these gels exhibit autochemotaxis and, thereby, can self-organize in response to self-generated chemical signals. These examples illustrate that BZ gels constitute optimal materials for creating millimeter-sized soft robots whose self-sustained movement can be regulated through the use of light.

Read More

Publication Of The Month | July 2014

By The McGowan Institute For Regenerative Medicine | Publication of the Month, Publication of the Month 2014 | July 30, 2015
Authors: Dutta-Moscato J, Solovyev A, Mi Q, Nishikawa T, Soto-Gutierrez A, Fox IJ, Vodovotz Y.

Title: A multiscale agent-based in silico model of liver fibrosis progression.

Summary: Chronic hepatic inflammation involves a complex interplay of inflammatory and mechanical influences, ultimately manifesting in a characteristic histopathology of liver fibrosis. We created an agent-based model (ABM) of liver tissue in order to computationally examine the consequence of liver inflammation. Our liver fibrosis ABM (LFABM) is comprised of literature-derived rules describing molecular and histopathological aspects of inflammation and fibrosis in a section of chemically injured liver. Hepatocytes are modeled as agents within hexagonal lobules. Injury triggers an inflammatory reaction, which leads to activation of local Kupffer cells and recruitment of monocytes from circulation. Portal fibroblasts and hepatic stellate cells are activated locally by the products of inflammation. The various agents in the simulation are regulated by above-threshold concentrations of pro- and anti-inflammatory cytokines and damage-associated molecular pattern molecules. The simulation progresses from chronic inflammation to collagen deposition, exhibiting periportal fibrosis followed by bridging fibrosis, and culminating in disruption of the regular lobular structure. The ABM exhibited key histopathological features observed in liver sections from rats treated with carbon tetrachloride (CCl4). An in silico “tension test” for the hepatic lobules predicted an overall increase in tissue stiffness, in line with clinical elastography literature and published studies in CCl4-treated rats. Therapy simulations suggested differential anti-fibrotic effects of neutralizing tumor necrosis factor alpha vs. enhancing M2 Kupffer cells. We conclude that a computational model of liver inflammation on a structural skeleton of physical forces can recapitulate key histopathological and macroscopic properties of CCl4-injured liver. This multiscale approach linking molecular and chemomechanical stimuli enables a model that could be used to gain translationally relevant insights into liver fibrosis.

Read More

Publication Of The Month | June 2014

By The McGowan Institute For Regenerative Medicine | Publication of the Month, Publication of the Month 2014 | July 30, 2015
Authors: Nishikawa T, Bellance N, Damm A, Bing H, Zhu Z, Handa K, Yovchev MI, Sehgal V, Moss TJ, Oertel M, Ram PT, Pipinos II, Soto-Gutierrez A, Fox IJ, Nagrath D.

Title: A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease.

Read More

Publication Of The Month | May 2014

By The McGowan Institute For Regenerative Medicine | Publication of the Month, Publication of the Month 2014 | July 30, 2015
Authors: Mathew S, Sundararaj S, Mamiya H, Banerjee I.

Title: Regulatory interactions maintaining self-renewal of human embryonic stem cells as revealed through a systems analysis of PI3K/AKT pathway.

Read More

Publication Of The Month | April 2014

By The McGowan Institute For Regenerative Medicine | Publication of the Month, Publication of the Month 2014 | July 30, 2015
Authors: Liao HT, Marra KG, Rubin JP.

Title: Application of Platelet-Rich Plasma and Platelet-Rich Fibrin in Fat Grafting: Basic Science and Literature Review.

Read More

Publication Of The Month | March 2014

By The McGowan Institute For Regenerative Medicine | Publication of the Month, Publication of the Month 2014 | July 30, 2015
Authors: Lui VW, Peyser ND, Ng PK, Hritz J, Zeng Y, Lu Y, Li H, Wang L, Gilbert BR, General IJ, Bahar I, Ju Z, Wang Z, Pendleton KP, Xiao X, Du Y, Vries JK, Hammerman PS, Garraway LA, Mills GB, Johnson DE, Grandis JR.

Title: Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer.

Read More

Publication Of The Month | February 2014

By The McGowan Institute For Regenerative Medicine | Publication of the Month, Publication of the Month 2014 | July 30, 2015
Authors: Glowacki AJ, Yoshizawa S, Jhunjhunwala S, Vieira AE, Garlet GP, Sfeir C, Little SR.

Title: Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes.

Read More

Publication Of The Month | January 2014

By The McGowan Institute For Regenerative Medicine | Publication of the Month, Publication of the Month 2014 | July 30, 2015
Authors: Badylak SF

Title: Decellularized Allogeneic and Xenogeneic Tissue as a Bioscaffold for Regenerative Medicine: Factors that Influence the Host Response.

Read More

  • site map
  • links
  • contact
  • subscribe to our newsletter
© Copyright 2019 McGowan Institute for Regenerative Medicine
A program of the University of Pittsburgh and the University of Pittsburgh Medical Center
  • Home
  • Our People
    • Faculty/Staff Bios (A-C)
    • Faculty/Staff Bios (D-I)
    • Faculty/Staff Bios (J-N)
    • Faculty/Staff Bios (O-S)
    • Faculty/Staff Bios (T-Z)
    • Core Faculty Publications
    • Administrative Resources
  • Our Innovations
    • Impact
    • Patent Matrix
    • Featured Innovations
      • Innovation Insights
      • Coulter Programs
      • Expert Exposés
      • Spinout Spotlight
    • Partnerships & Collaborations
      • Industry
      • Academia
      • Within Pitt
    • Contact
  • About Us
    • Welcome
    • Video
    • Statistics
    • Mission Statement
    • What Is Regenerative Medicine?
    • Contact Us
    • Clinical Site
  • Our Research
    • Focus Areas
      • Tissue Engineering and Biomaterials
      • Cellular Therapies
      • Medical Devices and Artificial Organs
      • Clinical Translation
    • Matrix
    • Centers
    • Laboratories
    • Clinical Trials
    • Initiatives
  • Media
    • Current News
    • News Archive
    • Video
    • Podcasts
    • Newsletter
    • Grant of the Month
    • Publication of the Month
    • Media Contact
    • Video Links
  • Professional Development
    • Seminar Series
    • Special Events
    • Student Interest Groups
    • CATER
    • Post-Doctoral Opportunities
    • Career Opportunities
    • Wiegand Summer Internship
    • Admissions
    • Summer School
    • 2019 Scientific Retreat
    • Human Performance Optimization Symposium
Regenerative Medicine at the McGowan Institute