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Projects

Bioreactor R&D, new technologies
Four compartmentalized hydroxyapatite cell scaffold for artificial capillary beds, with high-performance mass exchange and integral oxygenation; for bone marrow cells. Hollow fiber based stem cell expansion bioreactor. Analytical bioreactor for fetal and embryonic cell differentiation studies, and life cell imaging.

Maintenance and differentiation of cells in vitro for extracorporeal temporary clinical use as a hybrid organ
Bioreactors for extracorporeal liver support. The MLS CellModule.

Production of cells for cell transplantation
3D high density cell co-culture models for hematopoetic cells, immune cells, liver cells, pancreatic islet cells, neuronal cells, muscle cells and bone marrow stem cells. In vitro culture models for embryonic stem cells and stem cell differentiation / proliferation. Cell preservation/transport logistics for cell-based therapy.

Production of regenerative mediators by cells in bioreactors for regenerative medicine applications
Modular bioreactor perfusion system for adult and stem cell cultures; and extracorporeal plasma perfusion.

Development for therapy concepts
Modular Liver Support concept –MLS–. Tissue engineering in the skin wound.



Production of regenerative mediators by cells in bioreactors for regenerative medicine applications
Modular bioreactor perfusion system for adult and stem cell cultures; and extracorporeal plasma perfusion.

Clinical studies in Regenerative Medicine

R&D infrastructure projects
Quality Management System / GLP for the group.
Design control process implementation for technology development/FDA regulations.
International Intranet between partners.
CellNet Pages in Regenerative Medicine.
“Data Cube” Database for Bioreactor Parameter Assessment.
International Network Initiatives and the CellNet Project.
Bioreactors for extracorporeal liver support.
The MLS CellModule.
Four compartmentalized hydroxyapatite cell scaffold for artificial capillary beds, with high-performance mass exchange and integral oxygenation; for bone marrow cells.
Hollow fiber based stem cell expansion bioreactor.
Analytical bioreactor for fetal and embryonic cell differentiation studies, and life cell imaging.
Updated 22-Oct-2004