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Production of Scaffold Materials

Extracellular matrix (ECM) represents the structural and functional molecules secreted by the resident cells of every tissue in the body. The Badylak laboratory has extensive experience isolating and harvesting this ECM and producing usable formats for use in pre-clinical animal and bench top studies. We routinely produce ECM from tissue such as small intestine, urinary bladder and liver tissue, typically from porcine sources. The cells of these tissues are removed by physical, enzymatic, and/or chemical methods so that only the native ECM remains. This ECM can then be used as a wet hydrated form, multilaminate sheets, and hydrogel forms.

MANUAL removal of muscle layers from porcine urinary bladder

Hydrated
ECM
Lyophilized
ECM
     

Decellularized porcine liver

Hydrogel
ECM

 

Updated 06-Jan-2016