Dr. Badylak’s laboratory is a highly interdisciplinary environment. The major focus of the laboratory is the development of regenerative medicine strategies for tissue and organ replacement. The use of mammalian extracellular matrix (ECM) or its derivatives as an inductive template for constructive remodeling of tissue is a common theme of most research activities. The goal of all projects is clinical translation and improved patient care.
Most projects involve the combined efforts of life scientists, biomedical engineers, physicians, veterinarians, and a strong technical support staff.
Major Research Interests include:
- Cell-matrix interactions and cell signaling
- Biomaterials and Biomaterial/Tissue interactions
- Biomedical Engineering as it Relates to Device Development and Biomaterials
- Developmental Biology and its role in Regenerative Medicine
Active Research Projects include:
- Mechanisms of matrix scaffold remodeling in esophageal, tracheal, cardiovascular, lower urinary tract and musculotendinous tissue reconstruction
- Immune response of mammals to xenogeneic scaffolds
- Autologous stem cell recruitment in vivo during tissue reconstruction
- Degradation of ECM scaffolds and bioactive degradation products
- Mechanobiology and its relationship to tissue reconstruction
- Development of bioscaffolds for liver and heart regeneration
The Badylak laboratory thrives upon the collaborative efforts of its personnel. Currently there are five staff scientists (including cell biologists, engineers, immunologists, and molecular biologists), seven doctoral students, three post doctoral fellows, four technicians, two administrative assistants, one MD-PhD student, and approximately six undergraduate students. There are typically two or three visiting scientists in the laboratory and two or three clinical-surgeons involved in every active project. |
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