Title: Detection of aberrant hippocampal mossy fiber connections: Ex vivo mesoscale diffusion MRI and microtractography with histological validation in a patient with uncontrolled temporal lobe epilepsy
Title: Enhanced Neural Prosthetics Using Shared-Mode Control
Description: This project builds on the world’s most advanced program in brain-controlled robotic arms and hands for paralyzed individuals. A group of Pittsburgh scientists and engineers will enhance the performance of neural prosthetics, allowing a paralyzed person to manipulate an object. A prosthetic limb will operate under an individual’s brain control, with a boost from an artificial intelligence component designed to predict what the individual intends to do. This shared-mode control will enable people who have quadriplegia to dexterously handle objects with a robotic arm and hand, and thus increase their independence in daily life.
Title: Endotypes of thrombocytopenia in the critically ill
Description: Thrombocytopenia is extremely frequent in critically ill patients. However, the role of acute platelet responses in critically ill patients is not well studied, and the multifactorial etiology of thrombocytopenia in the ICU makes it difficult to understand, or understand whether or not to treat it. In several situations such as traumatic injury or sepsis, very low platelet counts have been to bleeding, thrombosis and end-organ injury. Platelets have been extensively studied as a key component of hemostasis, but a rapidly emerging concept is that platelets are also key effector cells in systemic inflammatory processes as both instigators of local and systemic inflammatory reactions and also participants in the inflammation that contributes to tissue injury. The link between platelets and inflammation is complex and bidirectional, as inflammatory ligands have been shown to regulate platelet function and activated platelets induce inflammatory responses in other cell types. The overarching theme of this proposal is to study platelet dynamics in critically ill patients, construct clinical endotypes of thrombocytopenia in this population, and to relate these endotypes to underlying mesoscale mechanisms through computational modeling. We will use a large electronic health record-based database and a tri-state trauma database as source data to construct these endotypes. We define endotype as clinical patterns defined along four dimensions: (1) baseline information (demographic, chronic disease burden, severity of illness and admitting diagnosis), (2) features of the platelet count time series (rate of decrease, nadir, etc.), (3) concurrent interventions, and (4) outcome. The computational approach will attempt to root clinical endotypes in mechanistic interpretations (or collections of alternative interpretations), contributing to focus basic science investiagtions, and to close key knowledge gaps preventing the design and use of targeted anti-platelet-inflammatory therapies in the critically ill. Computational models will be developed at different levels of complexity, with a specific attention to tie underlying mechanisms to functional assays routinely performed in thrombocytopenic patients, such as prothrombin time, activated coagulation time, and thromboelastogram.
Description: PUMP is a solution aimed at reducing hospital-acquired pressure ulcers, affecting an estimated 3 million patients annually. The monitoring and alert solutions, using wearable devices and hospital bed sensors, will provide real-time documentation of patient repositioning and a process to improve compliance with these preventative measures.
Title: IPA#14 – Development and Evaluation of Xenografts for Soft Tissue Reconstruction; IPA#15 – Development and/or Evaluation of Synthetic Materials, Synthetic/Biologic Material Composites, surgical hemostats/sealants/adhesives and/or Methods for Improving the Host Tissue Response to Such Materials; IPA#16 – Development and/or Refinement of In Vitro Methods which would Characterize and/or Predict the Host Response to a Test Article; and IPA#17 – Development / Refinement of Preclinical Models and Ex-Vivo Test Methods
By The McGowan Institute For Regenerative Medicine | News Archive, Vision | January 14, 2016
As reported by Heather Chronis in the Fall 2015 Sight & Sound newsletter of the Eye and Ear Foundation of Pittsburgh, McGowan Institute for Regenerative Medicine affiliated faculty member Barry Hirsch, MD, Director of the Division of Otology in the Department of Otolaryngology in the University of Pittsburgh School of Medicine, is highly regarded by his patients as compassionate and knowledgeable, and is nationally recognized for excellence in ear surgery. He came to the University of Pittsburgh in 1979 for a residency in Otolaryngology (ENT), after graduating from the University of Pennsylvania Medical School. His interview with the Chairman of the Department of Otolaryngology, Eugene N. Myers, MD, sealed the deal for relocating to Pittsburgh.
McGowan Institute for Regenerative Medicine affiliated faculty member Shawn Bengtson, RQAP-GLP, Quality Systems and Program Manager, McGowan Institute Center for Preclinical Studies, has been elected as the 2016 Chair of the University Specialty Section (USS) of the Society for Quality Assurance (SQA).
The McGowan Institute for Regenerative Medicine congratulates Abby Loneker who has been selected to receive the 2016 Student Award for Outstanding Research from the Society For Biomaterials. This prestigious award is specifically given to “student researchers at the undergraduate level who have shown outstanding achievement in biomaterials research.”